T3 Signaling in Skeletal Muscle: Growth, Fiber Type and Turnover

[ClassicGuyTj]

https://pmc.ncbi.nlm.nih.gov/articles/PMC4390064/

This review suggests that T3 is not inherently catabolic to muscle.

It highlights T3’s role in satellite cell activation, muscle regeneration, increased protein turnover, and a shift toward fast-twitch fiber characteristics.

In that context, mildly supraphysiological T3 levels (e.g. ~50 mcg), especially combined with sufficient calories, training, and anabolic support (AAS / HGH), might actually support muscle adaptation rather than cause muscle loss.


Curious to hear your thoughts: Do you think T3 is truly muscle-wasting by nature, or mainly context-dependent (energy balance, hormones, duration)?

 

[M@NU]

i am always taking between 30-40µg t3 and my free t3 value is in the upper range (6,2 on a range from 3,1-6,5)
imo, being at the upper range of t3 is beneficial for most lifters and i assume most would benefit from taking a small dose of t3.
I think everything up to 45-50µg will only have positives, esp if you are someone who has a slower metabolism from nature

 

[Stryker24]

https://pmc.ncbi.nlm.nih.gov/articles/PMC4390064/

This review suggests that T3 is not inherently catabolic to muscle.

It highlights T3’s role in satellite cell activation, muscle regeneration, increased protein turnover, and a shift toward fast-twitch fiber characteristics.

In that context, mildly supraphysiological T3 levels (e.g. ~50 mcg), especially combined with sufficient calories, training, and anabolic support (AAS / HGH), might actually support muscle adaptation rather than cause muscle loss.


Curious to hear your thoughts: Do you think T3 is truly muscle-wasting by nature, or mainly context-dependent (energy balance, hormones, duration)?

Nice find. Pretty interesting.