What qualifies as neededdont take it if not needed
Totally fair — and I respect the clarification.
Again, not saying 25mcg of T3 guarantees muscle loss. But the catabolic potential of exogenous T3 in calorie-restricted athletes has been documented.
For example:
• Stallknecht et al. (1999) – Increased T3 levels were linked to greater nitrogen excretion in endurance athletes.
• Rasmussen et al. (1989) – T3 administration raised protein turnover and muscle breakdown markers.
• Larsen et al. (2004) – Showed skeletal muscle catabolism in T3-supplemented caloric deficit states.
(These are just a few among others.)
So again, the point isn’t “don’t use T3” — it’s understand the context and manage it smart, especially for bodybuilders running PEDs and cutting.
Appreciate the exchange — this is where real learning happens.
Still waiting on these links.Could you post the actual literature by links. What I'm pulling up doesn't denote whats being described.
Same here.Still waiting on these links.
Still waiting on these links.
He’s seen it in his athletesSame here.
if its not in range on blood workWhat qualifies as needed
if its not in range on blood work
i have no clue what you yappin about i gave him a valid answerI know you are trying to get your post count up to access other areas of the board. I forget the fairly low number threshold (25?) but from what mods have said, it's not automated and that's to discourage a bunch of shotgun short posts on anything. They want to see 25(?) quality posts with real contribution or discussion to ensure access is granted to actual members who have and plan to continue contributing.
No dog in this fight/race. I had a few hundred posts before I even realized as I didn't come here for that. But I saw you say it and I don't think anyone has shared that facet with you but it's been posted plenty over the past few years. So if you have plenty of posts but no access - this is likely why.
Given this premise. Should someone not take, metformin, GLP-1RA-GIP, SGLT-2i, if they're not diabetic or in CKD or HF? Their blood work indicates no presence of morbidity. How about testosterone if someone isn't hypogonadal. What if someones GH/IGF-1 comes back normal on blood work. Should they not take GH? The list goes on-and-on.if its not in range on blood work
Agreement.. Speaking of Metformin - What is your view on its use in terms of health benefits? I know, I've read a lot about Metformin here, but just your perspective. ThanksGiven this premise. Should someone not take, metformin, GLP-1RA-GIP, SGLT-2i, if they're not diabetic or in CKD or HF? Their blood work indicates no presence of morbidity. How about testosterone if someone isn't hypogonadal. What if someones GH/IGF-1 comes back normal on blood work. Should they not take GH? The list goes on-and-on.
Genuine question.
did i say for any of those other compounds? every compound is different and used for different reasons i wouldn't use blood work to decide how much gh to take thats just pointlessGiven this premise. Should someone not take, metformin, GLP-1RA-GIP, SGLT-2i, if they're not diabetic or in CKD or HF? Their blood work indicates no presence of morbidity. How about testosterone if someone isn't hypogonadal. What if someones GH/IGF-1 comes back normal on blood work. Should they not take GH? The list goes on-and-on.
Genuine question.
Also would be interested. I see people mention GLP’s for insulin sensitivity...but we already have a proven drug specifically for this without the sides.Agreement.. Speaking of Metformin - What is your view on its use in terms of health benefits? I know, I've read a lot about Metformin here, but just your perspective. Thanks
My mind hasn't changed much over the years. I particularly don't take it anymore. May possibly reintroduced it in the near future. I feel it has it's place on activation of AMPK that helps reduce systematic inflammation, limiting ROS in turn putting the brakes on cytokines overexpression, and last but not least, improvements of insulin sensitivity. All hallmarks of supporting cellular function, theoretically modulating the aging process.Agreement.. Speaking of Metformin - What is your view on its use in terms of health benefits? I know, I've read a lot about Metformin here, but just your perspective. Thanks
Glp1s have been in use for 20 years. How is that not long enough to be proven?Also would be interested. I see people mention GLP’s for insulin sensitivity...but we already have a proven drug specifically for this without the sides.
Forgot to say metformin has side effects as well. I found for myself I just had to learn to manage glp-1 side effects. I only got constipation. I never got nausea. If I overate I got gassy and sulphur burps but that's more annoying for overeating than a side effect that would cause me to consider discontinuationGlp1s have been in use for 20 years. How is that not long enough to be proven?
What was your reason for using GLP’s? I'm operating under the assumption we all track our calories and stick to what we are suppose to be eating (disciplined). In that case metformin or berberine can be utilized to enhance insurance sensitivity on high carb diets or when using gh.Forgot to say metformin has side effects as well. I found for myself I just had to learn to manage glp-1 side effects. I only got constipation. I never got nausea. If I overate I got gassy and sulphur burps but that's more annoying for overeating than a side effect that would cause me to consider discontinuation
This was before I was into fitness like I am now. I was a 300 lb fat ass and wanted to change. my doctor suggested mounjaro. This was back in November of 22 so it was pretty new and there was a coupon for $25/month even without insurance approval. I just did it in steps from there. The medicine hit me like a wall. Just almost instantly full, no thinking about food, alcohol tasted horrible, food stopped giving me enjoyment. It was perfect but I knew I needed the fitness too. Got an elliptical and started using it almost daily. Then got some various weight kettlebells, then some adjustable kettlebell from beela of steel, an adjustable weight club, and started watching mark wildman videos and doing programs from kbomg. I got the rapid fatloss handbook and guide to flexible dieting from Lyle McDonald and then the weight really started to fall off because I finally understood calories, macros, and dieting since I had been told me while kids that I can't eat too little it I'll go into "starvation mode" and stop losing. Where the fuck did that come from by the way. Such BS. It progressed to weightlifting from there, trying to get ripped, learning while trying to get my wife pregnant that I had low test and low sperm count, started trt, then HCG and it worked. From there I started getting into gear and got a coachWhat was your reason for using GLP’s? I'm operating under the assumption we all track our calories and stick to what we are suppose to be eating (disciplined). In that case metformin or berberine can be utilized to enhance insurance sensitivity on high carb diets or when using gh.
Sounds to me like the basics and your dedication resulted in change vs the drug. From what I've seen most just use it as the bloat pill, aka physical discomfort (punishment) for abusing food. But either way props on your progress...proper eating and physical activity are always a winning combo!This was before I was into fitness like I am now. I was a 300 lb fat ass and wanted to change. my doctor suggested mounjaro. This was back in November of 22 so it was pretty new and there was a coupon for $25/month even without insurance approval. I just did it in steps from there. The medicine hit me like a wall. Just almost instantly full, no thinking about food, alcohol tasted horrible, food stopped giving me enjoyment. It was perfect but I knew I needed the fitness too. Got an elliptical and started using it almost daily. Then got some various weight kettlebells, then some adjustable kettlebell from beela of steel, an adjustable weight club, and started watching mark wildman videos and doing programs from kbomg. I got the rapid fatloss handbook and guide to flexible dieting from Lyle McDonald and then the weight really started to fall off because I finally understood calories, macros, and dieting since I had been told me while kids that I can't eat too little it I'll go into "starvation mode" and stop losing. Where the fuck did that come from by the way. Such BS. It progressed to weightlifting from there, trying to get ripped, learning while trying to get my wife pregnant that I had low test and low sperm count, started trt, then HCG and it worked. From there I started getting into gear and got a coach
Yeah man. My wife and sons is her family decided to try tirzepatide because of my progress and in two years she only lost maybe 15-20 lbs and I told her it's because she never did anything but inject the compound. Her family didn't see too much on progress either. I have a set account of calories per day, log every single thing I eat, mostly eat only protein, do cardio at least 4x a week lift weights 3-4x per week. You gotta do all those things too. The injection helps to keep the hunger pangs away and even seems to make food not quite as pleasurable but if that's all you do to lose weight you may lose it but you'll be flabby or skinny fat. You don't just want to lose weight. You want to lose fat and keep or at least try and gain muscle too. It's a definitely a lifestyle shift. I had to figure out how to view food simply as something I need to survive and build muscle and not as a daily event of something new and tasty to overindulge on. She hasn't figured that out for herself yet.Sounds to me like the basics and your dedication resulted in change vs the drug. From what I've seen most just use it as the bloat pill, aka physical discomfort (punishment) for abusing food. But either way props on your progress...proper eating and physical activity are always a winning combo!