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Tadalafil improves lean mass and endothelial function in nonobese men with mild ED

johnjuanb1

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Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization.
Aversa A, et al. Endocrine. 2017.

Abstract

PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference. We evaluated potential effects of daily tadalafil administration on body composition and investigated its possible mechanism(s) of action in C2C12 skeletal muscle cells in vitro.

METHODS: Forty-three men on stable caloric intake (mean age 48.5 ± 7; BMI 25.5 ± 0.9 kg/m2) complaining mild ED and/or low urinary tract symptoms (LUTS) were randomly assigned to receive tadalafil (TAD) 5 mg/daily (once-a-day=OAD-TAD; n = 23) or 20 mg on-demand (on-demand=OD-TAD; n = 20) for 2 months. Primary outcomes were variations of body composition measured by Dual-energy X-ray absorptiometry; secondary outcomes were ED/LUTS questionnaire scores along with hormone (testosterone, estradiol, insulin) and endothelial function (Endopat2000) variations.

RESULTS: OAD-TAD increased abdominal lean mass (p < 0.01) that returned to baseline after 2 months withdrawal. LUTS scores improved (p<0.01) in OD-TAD while ED scores improved (p < 0.01) in both groups. We found significant improvements in endothelial function (p < 0.05) that directly correlated with serum insulin (p < 0.01; r = 0.3641) and inversely correlated with estradiol levels (p < 0.01; r = 0.3655) even when corrected for potential confounders. Exposure of C2C12 cells upon increasing tadalafil concentrations (10-7 to 10-6 M) increased total androgen receptor mRNA and protein expression as well as myogenin protein expression after 24 and 72 h (2.8 ± 0.4-fold and 1.4 ± 0.02-fold vs. control, respectively, p < 0.05).

CONCLUSIONS: Daily tadalafil improved lean mass content in non-obese men probably via enhanced insulin secretion, estradiol reduction, and improvement of endothelial function in vivo. The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor.
 

MyNameIsJeff

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Nice find! This together with positive effects in BPH, lower blood pressure, better pumps, better boners, make it look like another staple drug.
 

alfresco

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My opinion

When it goes generic, it will become one of the most
prescribed meds (not in bodybuilding doses, but
something 5mg) for men for the reasons you mentioned.
And my Urologist agrees with me. I am on 5mg for ‘men’s
health.’ Love the stuff.

And when it does, it will be time to buy some stock in a
Pharm company that will be producing this in volumes
that will be unbelievable. I for one am following this one
very closely.

Cialis is expected to be available as generic tadalafil as
early as September of 2018. Previously, Cialis was
expected to remain brand-only until 2020.

Generally, generic drugs first appear on the market at
about a 15% discount to the brand. Unlike the brand,
however, generic drug prices typically decrease very
quickly. Within a year of release, many generics versions
of prescriptions can become very affordable, especially
if multiple companies are making the generic.
 

nothuman

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I know the makers of Cialis want it to be OTC. I see no reason it shouldn't be. Why does curing ED have to be so difficult? It's a real problem amongst a lot of the population, and can ruin relationships. It's a lot safer than Advil.
 

Elvia1023

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I know the makers of Cialis want it to be OTC. I see no reason it shouldn't be. Why does curing ED have to be so difficult? It's a real problem amongst a lot of the population, and can ruin relationships. It's a lot safer than Advil.

It is a lot safer for men but not for any women going out with JJ when he takes his 50mg tadalafil :star-war':eek:
 

superbigd

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Does anyone else get crazy headaches from the stuff? I love how it makes me feel but I get a gnarly headache
 

bigNsmall

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Absolutely love Tadalfil. 10mg pre workout and all the veins come out to play.
 

greaser13

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Does anyone else get crazy headaches from the stuff? I love how it makes me feel but I get a gnarly headache

I got headaches from it too until I reduced the dose. If you have sinus issues you might be more sensitive to it as well. I take a half pill now and have no sides.
 

dale338

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Be very careful with this approach. Frequent use of any of the PDE5's and you will begin developing a tolerance and they will stop working. In fact it's advisable that people take extended breaks to avoid it. Use it daily simply to have your veins pop a bit more, will yield less affective erections down the road. I abused these medications for like a year when I was trying to get my libido back in line and they almost didn't work anymore. I took a few months off them and they work again. But I only take when absolutely needed. It's well known that guys who use these drugs daily and heavily and up not working.
 

pickapeck

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Weight loss is from extra f*kking, multiple girlfriends and severe drama from multiple girlfriends. It reversed because no f*kking hence loss of multiple girlfriends and therefore end of drama. There should be a black box warning on these pills: End use before marriage occurs or drama surpasses tolerance.
 

someday

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Be very careful with this approach. Frequent use of any of the PDE5's and you will begin developing a tolerance and they will stop working. In fact it's advisable that people take extended breaks to avoid it. Use it daily simply to have your veins pop a bit more, will yield less affective erections down the road. I abused these medications for like a year when I was trying to get my libido back in line and they almost didn't work anymore. I took a few months off them and they work again. But I only take when absolutely needed. It's well known that guys who use these drugs daily and heavily and up not working.

Are there studies backing this up? I have been using low dose for about 2 years straight now daily and have seen no drop off. I use it mainly for BPH, but erection quality hasn't changed a bit while on TRT. Have been curious about long term effects, but 2 years is a pretty good stretch and not seeing anything noticeable save for the positives....no prostate discomfort and quality erections.
 

dale338

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Are there studies backing this up? I have been using low dose for about 2 years straight now daily and have seen no drop off. I use it mainly for BPH, but erection quality hasn't changed a bit while on TRT. Have been curious about long term effects, but 2 years is a pretty good stretch and not seeing anything noticeable save for the positives....no prostate discomfort and quality erections.

I don't think it would necessarily apply to those using daily low-dose. And I suppose if it started to be less effective you could just raise your daily dose slightly and it would carry you for years. I'm talking about people who use these medications excessively. Like guys taking 100mg of viagra a day or 20mg of of cialis every couple days because they want to be 100% assure they'll perform. Many (including myself) often mix these drugs. I got up to a point where I was using 150 or so milligrams of viagra before sex. And it stopped working very well until I took a break.

What got me on this path, was not that I couldn't get erections, I'm just 50 and it takes a bit longer. I date much younger women and they expect you to just be rock hard, from anything. Lol. Older women tend to understand men slow with age in how and what they need to get it up. Anyhow, I wanted to be assured that when her clothes started coming off I was rockhard. And I abused them built up a tolerance. After two months off, they worked great again.
 

nothuman

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Be very careful with this approach. Frequent use of any of the PDE5's and you will begin developing a tolerance and they will stop working. In fact it's advisable that people take extended breaks to avoid it. Use it daily simply to have your veins pop a bit more, will yield less affective erections down the road. I abused these medications for like a year when I was trying to get my libido back in line and they almost didn't work anymore. I took a few months off them and they work again. But I only take when absolutely needed. It's well known that guys who use these drugs daily and heavily and up not working.

I don't think it would necessarily apply to those using daily low-dose. And I suppose if it started to be less effective you could just raise your daily dose slightly and it would carry you for years. I'm talking about people who use these medications excessively. Like guys taking 100mg of viagra a day or 20mg of of cialis every couple days because they want to be 100% assure they'll perform. Many (including myself) often mix these drugs. I got up to a point where I was using 150 or so milligrams of viagra before sex. And it stopped working very well until I took a break.

What got me on this path, was not that I couldn't get erections, I'm just 50 and it takes a bit longer. I date much younger women and they expect you to just be rock hard, from anything. Lol. Older women tend to understand men slow with age in how and what they need to get it up. Anyhow, I wanted to be assured that when her clothes started coming off I was rockhard. And I abused them built up a tolerance. After two months off, they worked great again.

My experience exactly. The problem is I have no idea when I can take two months off because that means I'd have to abstain from sex. I've abused it so much and I need at least 60mg just in case. Really dug myself in a hole here.
 

dfresh333

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I'm glad someone mentioned the tolerance and performance drop off. When I used tren and deca I wouild fool myself I to thinking my body was fine and didn't get any erection side effects because my cock worked just fine ( with loads of Viagra and cialis). Eventually my hormones were so out of whack that along with tolerance, my junk just didn't work right.
 

RamboStallone

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I've been using 10-20mg for years, no tolerance build up as far as I can see. If your hormones are all jacked up, well Cialis/Viagra can't help there, it only helps erections. Libido and sex drive have to be in good standing for it to work.
 

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