Testosterone Carrier Oils (DHT)

[JackT1965]

I’ve done research online and have gotten multiple answers on this subject I am wanting to learn about.

I’ve seen different brands of Testosterone have different carrier oils.

My question is, since cypionite , enanthate and propirate all have different carbon molecules due to the ester rate and half life.

Does each one have a different effect on DHT conversion ? Is it due to the carrier oil that it is suspended in or is it due to the carbon molecule?

Is it true that one effect DHT conversion less than others ? If so which ones?

 

[Taeian clark]

I wrote on this recently. Studies showed the shorter the ester the more androgenic the hormone was. And the longer the ester the more estrogen was made. Even matching the blood levels half life wise the shorter esters was still twice, yes twice as androgenic as the longer esters.

The longer esters were also much more anabolic.

 

[SouthernMuscle]

I wrote on this recently. Studies showed the shorter the ester the more androgenic the hormone was. And the longer the ester the more estrogen was made. Even matching the blood levels half life wise the shorter esters was still twice, yes twice as androgenic as the longer esters.

The longer esters were also much more anabolic.

 

[M@NU]

I wrote on this recently. Studies showed the shorter the ester the more androgenic the hormone was. And the longer the ester the more estrogen was made. Even matching the blood levels half life wise the shorter esters was still twice, yes twice as androgenic as the longer esters.

The longer esters were also much more anabolic.

a long ester injected as frequently as a short ester result in less e2 conversion due to way more stable blood levels.

 

[dimethyl11]

I wrote on this recently. Studies showed the shorter the ester the more androgenic the hormone was. And the longer the ester the more estrogen was made. Even matching the blood levels half life wise the shorter esters was still twice, yes twice as androgenic as the longer esters.

The longer esters were also much more anabolic.

link the studies

 

[Scorpyd]

Carrier oil and DHT conversion are not related.

 

[Taeian clark]

a long ester injected as frequently as a short ester result in less e2 conversion due to way more stable blood levels.

Studies I have say otherwise. But I'm assuming no studies will be posted here anyways so opinion vs opinion.

 

[Taeian clark]

link the studies

Well obviously I can't because I totally made it up. Wild imagination I got.

 

[SouthernMuscle]

link the studies

Here’s what skynet has to say about the estrogen part-

Both testosterone propionate and testosterone cypionate undergo aromatization, a process where testosterone is converted to estradiol by the enzyme aromatase. However, there are some distinctions between the two regarding their conversion rates and effects.

Comparison of Aromatization Between Testosterone Propionate and Testosterone Cypionate

1. **Aromatization Process**
Both testosterone propionate and testosterone cypionate can be converted to estradiol through the action of aromatase, which is primarily located in adipose (fat) tissue. This process is crucial for various physiological functions, such as regulating bone density and libido.

2. **Aromatization Rates**
While specific conversion rates can vary among individuals, there isn't a substantial difference in the innate ability of testosterone propionate and testosterone cypionate to convert to estradiol. However, the pharmacokinetics of each form influences how quickly and effectively they have their effects, including estrogenic effects.

Testosterone Propionate**: This form has a shorter half-life, generally requiring injections every other day to maintain stable serum levels. Its rapid action can lead to quicker increases in estradiol levels shortly after administration.

Testosterone Cypionate**: In contrast, testosterone cypionate has a longer half-life and is typically administered less frequently, often every one to two weeks. The slower rise in serum testosterone levels can also lead to a gradual increase in estradiol levels.

3. **Clinical Implications**
In clinical practice, some studies suggest that individuals on testosterone therapy may experience varying estrogen levels influenced by the dosing frequency and formulation. For example, individuals using testosterone propionate may notice more pronounced immediate effects and potentially higher estrogen spikes shortly after their injections, compared to testosterone cypionate, which may provide more steady levels over time.

Conclusion
In summary, while both testosterone propionate and testosterone cypionate convert to estradiol through aromatization, the difference primarily lies in their pharmacokinetics and the potential rapidity of estrogen increase post-injection. Individual responses to treatment can also vary, depending on factors such as body composition and metabolism. Regular monitoring of estradiol levels during testosterone therapy is important to balance the benefits and potential side effects associated with elevated estrogen levels.

For individuals undergoing testosterone therapy, personalized approaches should be employed to manage estradiol levels effectively, particularly in managing symptoms or side effects that may arise from estrogen excess.



Sources:
[1] Testosterone Propionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/chemistry/testosterone-propionate
[2] What is Testosterone Propionate used for? - Patsnap Synapse, https://synapse.patsnap.com/article/what-is-testosterone-propionate-used-for
[3] Aromatization - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/nursing-and-health-professions/aromatization
[4] What is the mechanism of Testosterone Propionate?, https://synapse.patsnap.com/article/what-is-the-mechanism-of-testosterone-propionate
[5] [PDF] Testosterone and Aromatization: How To Avoid Excess Estrogen ..., https://www.blaineywellness.com/wp-...ow-to-avoid-excess-estrogrogen-production.pdf
[6] Conversion of blood androgens to estrogens in normal adult men ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC297476/
[7] Aromatase-independent testosterone conversion into estrogenic ..., https://pubmed.ncbi.nlm.nih.gov/16386416/
[8] Aromatase-independent testosterone conversion into estrogenic ..., https://www.sciencedirect.com/science/article/abs/pii/S0960076005004528
[9] Taking Anastrazole with Testosterone - Obsidian Mens Health, https://obsidianmenshealth.com/when-to-take-anastrazole-with-testosterone/
[10] Testosterone Cipionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topic...pharmaceutical-science/testosterone-cipionate
[11] Androgen Replacement - StatPearls - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK534853/
[12] Aromatase inhibitors in men: effects and therapeutic options - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3143915/
[13] Estrogen Levels Do Not Rise With Testosterone Treatment For ..., https://www.endocrinepractice.org/article/S1530-891X(20)35607-X/fulltext
[14] Aromatization of testosterone by adipose tissue and sexual behavior ..., https://pubmed.ncbi.nlm.nih.gov/7171663/
[15] Aromatization of androgens to estrogens mediates increased activity ..., https://pubmed.ncbi.nlm.nih.gov/7353518/
[16] Testosterone Propionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/nursing-and-health-professions/testosterone-propionate
[17] The role of aromatization in testosterone supplementation - PubMed, https://pubmed.ncbi.nlm.nih.gov/15668427/
[18] The Effects of Injected Testosterone Dose and Age on the ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2913038/
[19] Testosterone Cipionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/neuroscience/testosterone-cipionate

 

[SouthernMuscle]

link the studies

Aaaaand skynet on the “anabolic“ differences-

Testosterone propionate and testosterone cypionate are both forms of testosterone that are used in hormone replacement therapy and for performance enhancement due to their anabolic effects. However, their anabolic properties and effectiveness can vary based on different factors, including their pharmacokinetics and how they are metabolized in the body.

Anabolic Effects Comparison
1. Half-life and Administration
Testosterone Propionate**: This testosterone ester is known for its short half-life of approximately 19 hours. It requires more frequent injections—typically every 2-3 days—to maintain stable testosterone levels. The rapid onset and quick metabolism can lead to more pronounced fluctuations in testosterone levels, which can affect the anabolic response.

Testosterone Cypionate**: In contrast, testosterone cypionate has a longer half-life of about 8 days. This means it is typically administered every 1-2 weeks, which provides more stable blood levels and can lead to a more sustained anabolic effect.

2. Anabolic Potency
- Studies indicate that both testosterone propionate and cypionate can increase muscle size and strength; however, the difference in their anabolic efficiency can depend on individual response and administration regimen. Propionate may create a quick surge in testosterone levels, which could lead to rapid short-term anabolic responses, while cypionate’s slower release may promote longer-term muscle growth.

3. Research Findings
- Research shows that supraphysiologic doses of testosterone can lead to increases in fat-free mass and muscle strength, with both esters being effective. Yet, the precise comparative effectiveness of their anabolic properties has not been well quantified in direct head-to-head studies.

4. Side Effects and Tolerance
- Testosterone propionate's frequent injections and quick metabolism may also lead to more pronounced side effects related to high and low testosterone levels, such as mood swings and gynecomastia, due to higher rates of aromatization to estrogen. Conversely, cypionate’s longer half-life may provide a more balanced experience with potentially fewer side effects.

Conclusion
While testosterone propionate may provide quicker anabolic effects due to its rapid onset, testosterone cypionate offers a more stable and sustained anabolic environment due to its longer half-life. Therefore, determining whether one is more anabolic than the other may depend more on individual responses and specific usage contexts rather than a clear, definitive answer. Further research is warranted to elucidate the comparative anabolic effects of these two esters more thoroughly.

Sources:
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[2] Testosterone Propionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/medicine-and-dentistry/testosterone-propionate
[3] the protein anabolic and other effects of testosterone propionate in ..., https://academic.oup.com/endo/article/57/3/296/2759977
[4] What is Testosterone Propionate used for? - Patsnap Synapse, https://synapse.patsnap.com/article/what-is-testosterone-propionate-used-for
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[6] Anabolic Steroids - StatPearls - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK482418/
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[8] Testosterone Cypionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/chemistry/testosterone-cypionate
[9] The effects of supraphysiologic doses of testosterone on muscle size ..., https://pubmed.ncbi.nlm.nih.gov/8637535/
[10] The Effects of Supraphysiologic Doses of Testosterone on Muscle ..., https://www.nejm.org/doi/full/10.1056/NEJM199607043350101
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[12] Different Types of Injectable Testosterone - Defy Medical, https://www.defymedical.com/blog/different-types-of-injectable-testosterone/
[13] Testosterone Propionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topic...harmaceutical-science/testosterone-propionate
[14] Androgenic Steroids - LiverTox - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK548931/
[15] Testosterone Propionate - an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/nursing-and-health-professions/testosterone-propionate

@Taeian clark
maybe you should start utilizing skynet so you can at least SOUND like you know what you’re talking about

 

[azeliabvxnks]

hey, bumping kinda old thread cus im curios, still no one has studies? i tried to google it myself but havent found nothin'. I know in many testosterone discussions ppl just say try these meds, buy enclomiphene online, buy suplements and all will be fine but this thread seems different. Thats why i wanna know more bout DHT. Anyway my answer may look goofy so i wont upset if no one will respond here.
Have a great day everybody!