Testosterone pill approved by FDA

[Zarati]

For ED injectors, would you still rather do ED injections or take this 3-4 times a day for stable bloods


https://www.healio.com/endocrinolog...estosterone-capsule-for-men-with-hypogonadism

Or

https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm634585.htm

 

[Brickshthouse79]

Is this different from andriol?

 

[MightyJohn]

Is this different from andriol?

Article said it's TU...been out for years(andriol)...maybe it new that it's being"approved" for trt

 

[Steroidify Rep]

Interesting.

There's this too. Wonder how effective it is:

 

[Swifto]

"The efficacy of Jatenzo was demonstrated in a four-month clinical trial involving 166 men with hypogonadism. Study participants initially were given Jatenzo at a dose of 237 mg twice per day, and the dose was adjusted downward or upward to a maximum of 396 mg twice per day on the basis of testosterone levels. Eighty-seven percent of Jatenzo-treated men achieved an average testosterone level within the normal range, which was the primary study endpoint."

 

[Delt123]

"The efficacy of Jatenzo was demonstrated in a four-month clinical trial involving 166 men with hypogonadism. Study participants initially were given Jatenzo at a dose of 237 mg twice per day, and the dose was adjusted downward or upward to a maximum of 396 mg twice per day on the basis of testosterone levels. Eighty-seven percent of Jatenzo-treated men achieved an average testosterone level within the normal range, which was the primary study endpoint."

Damn, close to 800mg per day to reach normal levels

 

[Zarati]

How does it pass the liver? Would it be toxic?

 

[Serotonin]

How does it pass the liver? Would it be toxic?

This is exactly what I was thinking

 

[Brickshthouse79]

Believe its the same as andriol. Its not methylated, , see below, it gets absorbed by the intenstines lymphatically. The issue is the poor bioavailability which requires a large oral dose (400mg twice daily).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168025/
"Despite the potential advantages of an oral testosterone formulation, extensive first-pass hepatic metabolism limits oral bioavailability of T and its esters (Tauber et al, 1986). Consequently, renewed effort has been focused on developing T prodrug formulations, such as T undecanoate (TU), to enhance delivery via intestinal lymphatics, thereby bypassing hepatic metabolism and optimizing bioavailability. TU was selected because it is highly lipophilic and is preferentially absorbed by intestinal lymphatics in contrast with other T esters, which are less lipophilic and mainly absorbed via the portal system (Horst et al, 1976). In this study, TU was formulated into a new proprietary self-emulsifying drug delivery system (SEDDS) formulation"

 

[Brickshthouse79]

P.s - I took andriol once in the early 2000s. I remember my face broke out in acne. It definitely worked but the dosing made it expensive. I think it required around 6 caps a day, so a bottle wouldnt last long.

 

[rookx750]

How does it pass the liver? Would it be toxic?

Ya that dose and not mytho still going to start fucking up something in the long run. No question about it, if it gets to market it will be pulled.

It does pass through the liver just like every testosterone but from my understanding is it’s not mythol so that’s what it’s soo high dosed I bet ppl with good metabolic rates this drug will have them all over the place. I think the sublingual drug route that actually works for long stead rate would of been a better approach.

 

[Ashop]

P.s - I took andriol once in the early 2000s. I remember my face broke out in acne. It definitely worked but the dosing made it expensive. I think it required around 6 caps a day, so a bottle wouldnt last long.

As far as bodybuilding I didn't like ANDRIOL at all. Very weak and very expensive.

 

[RamboStallone]

I'll stick to once a week injections. That many pills I'd probably have stomach issues anyway lol.

 

[aphextwin]

I'll stick to once a week injections. That many pills I'd probably have stomach issues anyway lol.

Totally agree.

 

[johnjuanb1]

I'll stick to once a week injections. That many pills I'd probably have stomach issues anyway lol.

I’m liking daily subQ injects. With a 27 gauge pin it’s very quickly done upon waking.

 

[aphextwin]

John, So you are on TRT now.

 

[johnjuanb1]

John, So you are on TRT now.

Yeah. I’m playing with the dose until it feels right.
I just upped it to 20mg test(prop/phenylprop)daily and 10mg NPP daily.
I may blast and cruise.
I want the muscle I lost back.

 

[Brickshthouse79]

Yeah. I’m playing with the dose until it feels right.
I just upped it to 20mg test(prop/phenylprop)daily and 10mg NPP daily.
I may blast and cruise.
I want the muscle I lost back.

Do you notice any benefits from adding 10mg of npp to your trt? Im thinking of adding it for a bit but probably at 20mg/day.

 

[johnjuanb1]

Do you notice any benefits from adding 10mg of npp to your trt? Im thinking of adding it for a bit but probably at 20mg/day.

My joints feel better but adding testosterone after having none for 9 months could have helped that issue.