This is the complete tendon thread. I will list a few bullet points, supplements, and therapies for healing, strengthening tendons.
I am just a bro so excuse my science.
* Human tenocytes are stimulated to proliferate by acetylcholine.
Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway
* GH therapy may weaken tendon to bone injuries in the first 21 days post injury/surgery. (this may be because it takes 14-21 days for the hypo-cellular tendon tissue to be populated with fibrolasts/tenocytes and to take on mechano-sensitive properties.)
Human growth
hormone may be detrimental... [J Bone Joint Surg Am. 2013] - PubMed - NCBI
* In healthy tendons (I would argue, mechano-responsive tendons) GH therapy/elevated IGF increases mRNA expression, and collagen synthesis by 1-3 fold.
Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
*IGF and MGF have both been found to be expressed in TENDON and muscle by mechanical stimulation and responsive to systemic rise in IGF/GH
*It may take 8-10 weeks for healthy tendons to become stronger from loading.
* adding in ANY KIND of mechanical load as SOON as the tendon becomes mechano-sensitive post injury/operation will result in a stronger tendon.
This study points to days 2-14 in rats, while others point to days 7-21
"The results showed that just four loading episodes increased the strength of the healing tendon. This was evident irrespective of the time point when loading was applied (early or late). The positive effect on early healing was unexpected, considering that the mechanical stimulation was applied during the inflammatory phase, when the calluses were small and fragile. A histological study of additional groups with early loading also showed some increased bleeding in the loaded calluses. Our results indicate that a short episodes of early loading may improve the outcome of tendon healing. This could be of interest to clinical practice."
Achilles tendon healing in rats is improved by ... [J Orthop Res. 2012] - PubMed - NCBI
* CIPRO, levaquin and other fluoroquinolone antibiotics kill tendons by increasing catabolism, destroying tendon cells, stopping the migration of cells during healing, and blocking anabolic pathways.
Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium-Deficient Diet
The result is incomplete healing, HYPOcellular tendons, and strains. Adding in things that restart the FAK pathway and tendon cell migration is CRUCIAL for healing from Cipro induced tendon damage.
This would include MGF, laser therapy, bpc 157, microcurrent therapy.
Coming Later,supplements.
The Complete Tendon thread-strain, surgery, strength
I am just a bro so excuse my science.
* Human tenocytes are stimulated to proliferate by acetylcholine.
Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway
* GH therapy may weaken tendon to bone injuries in the first 21 days post injury/surgery. (this may be because it takes 14-21 days for the hypo-cellular tendon tissue to be populated with fibrolasts/tenocytes and to take on mechano-sensitive properties.)
Human growth
hormone may be detrimental... [J Bone Joint Surg Am. 2013] - PubMed - NCBI
* In healthy tendons (I would argue, mechano-responsive tendons) GH therapy/elevated IGF increases mRNA expression, and collagen synthesis by 1-3 fold.
Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
*IGF and MGF have both been found to be expressed in TENDON and muscle by mechanical stimulation and responsive to systemic rise in IGF/GH
*It may take 8-10 weeks for healthy tendons to become stronger from loading.
* adding in ANY KIND of mechanical load as SOON as the tendon becomes mechano-sensitive post injury/operation will result in a stronger tendon.
This study points to days 2-14 in rats, while others point to days 7-21
"The results showed that just four loading episodes increased the strength of the healing tendon. This was evident irrespective of the time point when loading was applied (early or late). The positive effect on early healing was unexpected, considering that the mechanical stimulation was applied during the inflammatory phase, when the calluses were small and fragile. A histological study of additional groups with early loading also showed some increased bleeding in the loaded calluses. Our results indicate that a short episodes of early loading may improve the outcome of tendon healing. This could be of interest to clinical practice."
Achilles tendon healing in rats is improved by ... [J Orthop Res. 2012] - PubMed - NCBI
* CIPRO, levaquin and other fluoroquinolone antibiotics kill tendons by increasing catabolism, destroying tendon cells, stopping the migration of cells during healing, and blocking anabolic pathways.
Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium-Deficient Diet
The result is incomplete healing, HYPOcellular tendons, and strains. Adding in things that restart the FAK pathway and tendon cell migration is CRUCIAL for healing from Cipro induced tendon damage.
This would include MGF, laser therapy, bpc 157, microcurrent therapy.
Coming Later,supplements.
The Complete Tendon thread-strain, surgery, strength