The future of mitochondria peps - When are they coming?

[SwedishSteel]

Just a few years ago nobody was talking about the mitochondria, except the anti aging industry. Now we all know its the nr1 system in the body. not just for health but the strength of our mito decide how well we pack on muscle, how well we respond to aas, how well we can burn fat n recover from the gym.

we now also know how high doses of aas and prepp cycles to stage causes mitochondria dysfunction wich then causes the massive fatigue leading up to shows, wich can be counterd with these therapies and block the heart n organ damage effect so you dont rapidly age premature

Before this this time all the peptides were to expencive to acually run (in the doses needed). just a few years ago one vial of 10mg mots c was 50 bucks. now a entire kit of 40mg is 180-200 usd. wich makes us regular mortals be able to buy and use it

So it seems like right now we are in the golden era of peptide use. Wich will dramatically increase our lifespan n healthspan. there is no reason for you to wait until your body is broken to run tb 500, everyone could be on 2mg per day 5 days a week without becoming economically ruined. constantly regenerating the body. same with ghk cu

either way, i made this thread cause i wanna talk about the upcoming peptides (and if there even is one)

Cause NONE of the mitochondria peptides n so on are new. they are acually very old. over a decade old

There havent been a "new" peptide in very very long time except the glp1s. belive thymosine alpha 1, mots c and the rest are over 15 years old. ss31 is the newest wich is a decade old. but a decade without any progress is a very long time

also SLU pp332 isent a peptide but at least it came to the market really fast

But what will come next, why arent we seeing 5-10 different mitochondria peptides that they are running clinical trails on that china then starts mass producing just like they do with all the rest of the peptides

We dont need 100 different glps that do the exact same thing aka regulating insulin (and burn fat, yes even triz burns fat not just reta). what we have is enough, what we instead need are the mito peps. What mots c do isent close to enough to be a "game changer". maby if i tripple the dose who knows. its possbile that we in 10 years time find out that we are microdosing these mito peps

Just like with ss31 were they do 50mg per day in clinical trails. that are for disease tho. seen some really good muscle growth n 3d fullness with guys running 10mg per day. most run 3-5mg and feel nothing

Gonna swich my mots c for ss31 on my next order and see whats up

Either way, what do you think about the upcoming peptides? were are they and when are they arriving

 

[traininsane11]

and when are they arriving

A peptide is never late it arrives precisely when it means to - pepgalf

IYKYK

 

[SwedishSteel]

A peptide is never late it arrives precisely when it means to - pepgalf

IYKYK

Before WW3 i hope

 

[Reno911]

With all the mitochondrial peps out there right now, I think that people forget that they need to expedite getting rid off the damaged ones. Daily Urolithin A helps do this. Think of it as similar to how antioxidants work with free radicals.

It's got a lot of other benefits- see below.

https://www.sciencedirect.com/science/article/pii/S2589004225000744

 

[SwedishSteel]

With all the mitochondrial peps out there right now, I think that people forget that they need to expedite getting rid off the damaged ones. Daily Urolithin A helps do this. Think of it as similar to how antioxidants work with free radicals.

It's got a lot of other benefits- see below.

https://www.sciencedirect.com/science/article/pii/S2589004225000744

Mitophagy is one of the effects of almost all mito supps, including certen b vitamins. they clean out the damaged once and build new. but agree urolithin seems great. im using shilajit wich contains multiple urolithin (belive both a and b urolihin is found) and really increase energy/clarity/mito

 

[buck]

I have worked at trying to clear out my senescent cells . But i think they are winning.

 

[qbkilla]

Give it 20 years gyms and fitness will be a thing of the past...there will be a peptide to be lean another t9 build muscle. Then we won't even need them, we will just at birth be gene doped to have the perfect body. Instead of hoping for the next drug we should be grateful we are old enough that we spent our prime in a time when a semblance of work ethic gave as an advantage over the slob on the couch eating doritos.

 

[hogan87]

What mots c do isnt close to enough to be a "game changer". maby if i tripple the dose who knows. its possbile that we in 10 years time find out that we are microdosing these mito peps

Just like with ss31 were they do 50mg per day in clinical trails. that are for disease tho. seen some really good muscle growth n 3d fullness with guys running 10mg per day. most run 3-5mg and feel nothing

Gonna switch my mots c for ss31 on my next order and see whats up

What are you expecting from mitochondria efficiency peptide? This mentality goes right along with "micro-dosing" everything and running a "health phase". You want growth? Up your T and eat more, lift like you mean it. You wanna get shredded, stop filling your pie hole. There is NEVER going to be some magic peptide that does it better.

 

[Stewie]

Why do people heavily focus on one particular organelle? It's rave trendy with all the talking-heads. MAMs– ER stress need lovens too.

 

[SwedishSteel]

I have worked at trying to clear out my senescent cells . But i think they are winning.

Lifting weight do this pretty well, wich is one of the reasons people who work out looks so much healthier, spec females

 

[SwedishSteel]

What are you expecting from mitochondria efficiency peptide? This mentality goes right along with "micro-dosing" everything and running a "health phase". You want growth? Up your T and eat more, lift like you mean it. You wanna get shredded, stop filling your pie hole. There is NEVER going to be some magic peptide that does it better.

Im expecting that we are going to have a peptide that work as well as NAD+ IV but not just one, multiple. were the days of chronic inflammation n fatigue is gone, were you feel like the guy in limitless - every day - wich we already can do with nad+ IV. but who got money and time for 3 hour iv infusions 3 times per week ala 500 usd each

The difference of running a life with heavy training and a stimulant addiction vs having your mito so optimized at producing energy from all of these therapies is the difference between living in hell and living in paraside

Yet non of these therapies are strong enough to be a game changer right away (exept iv nad). But i will say that my combination of them are getting pretty close and im only a month in. will most likely be flying after running this for 6 months straight

 

[buck]

Lifting weight do this pretty well, wich is one of the reasons people who work out looks so much healthier, spec females

Guess i have been doing it wrong the 45ish years i have lifted weights. I easily look my age from the neck up.

 

[Stewie]

I have worked at trying to clear out my senescent cells . But i think they are winning.

You could explore a few different senomorphic supplements, e.g., apigenin, Urolithin A, 70–100% cacao dark chocolate amongst a few others are a reasonable, accessible way to "tame" the inflammatory impact of senescent cells.

As previously aforementioned – looking at strategies to enhance MAMs (mitochondria endoplasmic reticulum associated membrane) is the circle-chatter in the anti-aging tribe.

Mitochondria-Associated Membranes in Aging and Senescence

<p>Although the pursuit of eternal youth remains elusive, progress in the fields of medicine and science has greatly extended the human lifespan. Nevertheless, the rising incidence of diseases and their economic impact present notable obstacles. Mitochondria-associated membranes (MAMs)...

www.aginganddisease.org

 

[buck]

You could explore a few different senomorphic supplements, e.g., apigenin, Urolithin A, 70–100% cacao dark chocolate amongst a few others are a reasonable, accessible way to "tame" the inflammatory impact of senescent cells.

As previously aforementioned – looking at strategies to enhance MAMs (mitochondria endoplasmic reticulum associated membrane) is the circle-chatter in the anti-aging tribe.

Mitochondria-Associated Membranes in Aging and Senescence

<p>Although the pursuit of eternal youth remains elusive, progress in the fields of medicine and science has greatly extended the human lifespan. Nevertheless, the rising incidence of diseases and their economic impact present notable obstacles. Mitochondria-associated membranes (MAMs)...

www.aginganddisease.org

I have used 100% cacao in my protein drinks for some time. I tried Quercetin and Fisetin as they seemed to have some studies to support them for a while in the past but can't say i noticed anything. Maybe i a setting my sights to high though.
I will do some more reading and look into the other things you mentioned,
Thanks

 

[Stewie]

Why do people heavily focus on one particular organelle? It's rave trendy with all the talking-heads. MAMs– ER stress need lovens too.

In case the readers aren't aware –By and-large the endoplasmic reticulum (smooth and rough) is the more prominent anabolic organelle. Be respectful of limiting–avoid inducing excessive ER stress. When we bastardize this little organelle ‐ it over-stresses mitochondria bioenergetics. Which distances the tethering between the MAMs– limiting autophagic flux and apoptosis– accelerating the aging process.

Time for bed.

 

[qbkilla]

Random question, why is the word "inflammation " so popular the past year? I see it here, I see it all over any cholesterol, thyroid, fitness group social media "my doctor says I have inflammation, what should I take?"

What exactly are we referring to when we always talk about inflammation and why was this word not used daily by people 3 , 4, 5 years ago? Am I crazy or are other people noticing that they are seeing the word inflammation 20x more often than a few years ago lol.

 

[Cv215]

I guess I’ve been out of the game for a bit. I didn’t realize these peptides actually did anything? I mean besides hgh which obviously works. I was always under the impression most peptides were a scam. Well I used MT2 like 7 or 8 years ago that one definitely works.

 

[Sectør]

Random question, why is the word "inflammation " so popular the past year? I see it here, I see it all over any cholesterol, thyroid, fitness group social media "my doctor says I have inflammation, what should I take?"

What exactly are we referring to when we always talk about inflammation and why was this word not used daily by people 3 , 4, 5 years ago? Am I crazy or are other people noticing that they are seeing the word inflammation 20x more often than a few years ago lol.

Inflammation is very important for longer term health and encompasses a lot of bodily functions. Most people hear inflammation and think it means they’re maybe a little bit swollen or sore or puffy, but it goes far beyond that.

Some of the biggest risks of high chronic inflammation being:
- Cardiovascular health and increased likelihood of cardiovascular events (increased blood clot risk, increased plaque formation in arteries, makes the plaque more unstable which increases heart attack risk)
- increases mitochondria damage, oxidative stress
- raises cortisol levels and can hinder t4 to t3 thyroid conversion
- negative affects on the brains neurotransmitters
- inhibits mTOR (body’s muscle building pathway), and increases likelihood of muscle protein Breakdown


Among many other negative outcomes. I think as time goes on, the information available gets better, and people’s approaches change with it. There’s definitely been more of a shift towards mitochondria optimization lately. I think keeping inflammation low has always been inportant, but maybe it wasn’t fully understood how important within the bodybuilding community.

 

[Josefein421]

Inflammation is very important for longer term health and encompasses a lot of bodily functions. Most people hear inflammation and think it means they’re maybe a little bit swollen or sore or puffy, but it goes far beyond that.

Some of the biggest risks of high chronic inflammation being:
- Cardiovascular health and increased likelihood of cardiovascular events (increased blood clot risk, increased plaque formation in arteries, makes the plaque more unstable which increases heart attack risk)
- increases mitochondria damage, oxidative stress
- raises cortisol levels and can hinder t4 to t3 thyroid conversion
- negative affects on the brains neurotransmitters
- inhibits mTOR (body’s muscle building pathway), and increases likelihood of muscle protein Breakdown


Among many other negative outcomes. I think as time goes on, the information available gets better, and people’s approaches change with it. There’s definitely been more of a shift towards mitochondria optimization lately. I think keeping inflammation low has always been inportant, but maybe it wasn’t fully understood how important within the bodybuilding community.

Is some inflammation not a normal and healthy response though? So to look to damped that goes against the body's natural process does it not? I mean if you are training hard 5 days a week you are going to have some level of chronic inflammation as a normal response. Take a week off from the gym and if it sustains there is an issue.

From my knowledge you are right about everything you posted however IMO inflammation concerns are greatly over blown.

 

[Anabolix8]

You’re basically describing what a lot of people are starting to realize late. The compounds feel new, but the science isn’t. Most mitochondrial peptides have been around for well over a decade. What changed is cost and awareness, not discovery.

The reason we’re not seeing a flood of new mito peptides isn’t lack of progress, it’s incentive. GLP drugs print money fast. Mitochondrial therapies take longer to prove, are harder to patent, and don’t create the same dependency. Pharma follows revenue, not optimization.

I also think we’re underdosing most of these compounds. SS31 is a good example. Clinical doses are far higher than what most people run for performance. Same pattern we saw with GH years ago. Low doses feel subtle, higher or longer use is where structural changes start showing up.
TB500 and GHK Cu make more sense as long term signaling tools rather than injury fixes. Waiting until something breaks is outdated thinking.

What’s probably coming next won’t be ten new peptides, but better combinations that hit mitochondrial output, mitophagy, inflammation, and redox balance together. We’re early, and in a few years we’ll probably realize we were barely scratching the surface dose wise.

SS31 over MOTS c is a logical experiment. That’s where you’ll notice differences in endurance, fullness, and fatigue first.

Just a few years ago nobody was talking about the mitochondria, except the anti aging industry. Now we all know its the nr1 system in the body. not just for health but the strength of our mito decide how well we pack on muscle, how well we respond to aas, how well we can burn fat n recover from the gym.

we now also know how high doses of aas and prepp cycles to stage causes mitochondria dysfunction wich then causes the massive fatigue leading up to shows, wich can be counterd with these therapies and block the heart n organ damage effect so you dont rapidly age premature

Before this this time all the peptides were to expencive to acually run (in the doses needed). just a few years ago one vial of 10mg mots c was 50 bucks. now a entire kit of 40mg is 180-200 usd. wich makes us regular mortals be able to buy and use it

So it seems like right now we are in the golden era of peptide use. Wich will dramatically increase our lifespan n healthspan. there is no reason for you to wait until your body is broken to run tb 500, everyone could be on 2mg per day 5 days a week without becoming economically ruined. constantly regenerating the body. same with ghk cu

either way, i made this thread cause i wanna talk about the upcoming peptides (and if there even is one)

Cause NONE of the mitochondria peptides n so on are new. they are acually very old. over a decade old

There havent been a "new" peptide in very very long time except the glp1s. belive thymosine alpha 1, mots c and the rest are over 15 years old. ss31 is the newest wich is a decade old. but a decade without any progress is a very long time

also SLU pp332 isent a peptide but at least it came to the market really fast

But what will come next, why arent we seeing 5-10 different mitochondria peptides that they are running clinical trails on that china then starts mass producing just like they do with all the rest of the peptides

We dont need 100 different glps that do the exact same thing aka regulating insulin (and burn fat, yes even triz burns fat not just reta). what we have is enough, what we instead need are the mito peps. What mots c do isent close to enough to be a "game changer". maby if i tripple the dose who knows. its possbile that we in 10 years time find out that we are microdosing these mito peps

Just like with ss31 were they do 50mg per day in clinical trails. that are for disease tho. seen some really good muscle growth n 3d fullness with guys running 10mg per day. most run 3-5mg and feel nothing

Gonna swich my mots c for ss31 on my next order and see whats up

Either way, what do you think about the upcoming peptides? were are they and when are they arriving