The game changer for hair regrowth? PP405

[aDw32]

A new drug for hair regrowth has emerged. It may be the most powerful solution for restoring hair. When combined with minoxidil, finasteride or dutasteride could be particularly effective

PP405 is a novel, non-invasive, topical small molecule designed to reactivate dormant hair follicle stem cells and restart hair growth. Through a regenerative medicine approach, the treatment focuses on addressing the metabolic processes that regulate the activation and inactivation phases of hair follicle stem cells. Early results from a Phase 1 trial show that PP405 was well-tolerated and demonstrated statistically significant activation of hair follicle stem cells. In 2018, Pelage Pharmaceuticals licensed the intellectual property to PP405 and related topical small molecules from UCLA. Information on the Phase 2a study can be found on ClinicalTrials.gov.

 

[buck]

Pretty sure i would need at least an IV drip to see any effect.

 

[Siggy]

I dunno but they need to come up with something real fucking soon. Im receding like a mofo over here.

 

[Reload]

I'm 56 and fighting to keep my hair from thinning. Microneedling (stamping), topical and oral minoxidil. Nizoral shampoo and contemplating Dutasteride.
Seeing my dermatologist next week so fingers crossed. I'm one of the lucky ones who never developed MPB until recently whereas I've got
friends that started losing their hair in their early 20's. This PP405 looks promising but I need it now! From everything I've read I should have been
doing this "preventative maintenance" years ago. I've got a full head of hair still it's just thinning. I'm not ready to buzz/shave it all off just yet.

 

[whacked]

A. WAIT
“Potential Availability:
If all goes well, PP405 may become commercially available around 2028 or 2030”

-OR-

B. Potentially get scammed by the research version. lol

ProjectK Labs

ProjectK Labs

www.projectklabs.com

 

[Siggy]

A. WAIT
“Potential Availability:
If all goes well, PP405 may become commercially available around 2028 or 2030”

-OR-

B. Potentially get scammed by the research version. lol

ProjectK Labs

ProjectK Labs

www.projectklabs.com

2030? Great, I will be bald by then.

 

[Siggy]

Would anyone consider a "Hair System" ? (aka known as a wig FFS )

When I first saw a man wearing a modern wig a couple of years ago, I thought to myself never in a million years would I be caught dead wearing a wig, what a stupid and vain thing for a man to do.

But why not? Many women wear wigs and fake weaves for their entire life. Plus, a slim muscular man still looks good after he takes the wig off, women yea not so much.

I mean, is this actually any worse than getting a hair transplant where they butcher and permanently scar the harvest area in the back of your head? And knowing that the transplanted hair will still eventually fall out? And might fall out immediately if they did a terrible job or you just had shitty hair genetics?

 

[Siggy]

Would anyone consider a "Hair System" ? (aka known as a wig FFS )

When I first saw a man wearing a modern wig a couple of years ago, I thought to myself never in a million years would I be caught dead wearing a wig, what a stupid and vain thing for a man to do.

But why not? Many women wear wigs and fake weaves for their entire life. Plus, a slim muscular man still looks good after he takes the wig off, women yea not so much.

I mean, is this actually any worse than getting a hair transplant where they butcher and permanently scar the harvest area in the back of your head? And knowing that the transplanted hair will still eventually fall out? And might fall out immediately if they did a terrible job or you just had shitty hair genetics?

And then on top of that you had to cover your butchered scalp for a year and hope that they did a good job?

 

[aDw32]

A. WAIT
“Potential Availability:
If all goes well, PP405 may become commercially available around 2028 or 2030”

-OR-

B. Potentially get scammed by the research version. lol

ProjectK Labs

ProjectK Labs

www.projectklabs.com

Retatrutide will be officially on the market in few years.. "Given the typical timeline for FDA approval, the medication may not be on the market until 2027." (Reta)

So, we should have PP405 available soon..

 

[pistonpump]

The Chinese will be putting it out soon I'm willing to bet

 

[aDw32]

Result were visible as soon as after 4 weeks

"Note that the trial participants just had 4 weeks of treatment. At another 4 weeks after the completion of this treatment (“in men with a higher degree of hair loss”), 31% of those treated with PP405 exhibited a greater than 20% increase in hair density. In comparison, 0% of patients in the placebo group responded favorably. These results are incredibly rapid in comparison to existing treatments."

 

[sandiego_2008]

Until i see Bezos or another one of these bald tech billionaires suddenly have a full, thick head of hair, im not buying it. Hell, even LeBron James cant find an answer for his MPB.

 

[aDw32]

Until i see Bezos or another one of these bald tech billionaires suddenly have a full, thick head of hair, im not buying it. Hell, even LeBron James cant find an answer for his MPB.

Strange reasoning.

Do you realize the pace of development we have now thanks to AI, modern methods, and also stem cells?

Do you know that this year, for the first time, a person with type 1 diabetes was cured using stem cells? He is no longer diabetic… for the first time since birth, his pancreas has started producing insulin..

Do you know that in Japan, they are already able to grow new teeth using stem cells and it’s actually happening?

According to your approach, that would mean it’s impossible just because it wasn’t possible for decades… What’s happening now in medicine and biotechnology is truly mind blowing

Literally, we are entering a new era..

 

[GreatGhandi51]

Until i see Bezos or another one of these bald tech billionaires suddenly have a full, thick head of hair, im not buying it. Hell, even LeBron James cant find an answer for his MPB.

Surgery bro; move your old DHT resistant hairs to the front.

If youve lost 15/50 of your hairs at the front and look balf, your not getting those 15 back.

 

[Anickanoppe]

Alongside treatments like that, using gentle, nourishing products helps keep the scalp healthy—something like the Mily CR line really calms irritation and supports skin balance.

 

[dudebroftw]

Any sides from it like dht going down?

 

[foninar]

A new drug for hair regrowth has emerged. It may be the most powerful solution for restoring hair. When combined with minoxidil, finasteride or dutasteride could be particularly effective

PP405 is a novel, non-invasive, topical small molecule designed to reactivate dormant hair follicle stem cells and restart hair growth. Through a regenerative medicine approach, the treatment focuses on addressing the metabolic processes that regulate the activation and inactivation phases of hair follicle stem cells. Early results from a Phase 1 trial show that PP405 was well-tolerated and demonstrated statistically significant activation of corte de cabelo masclulino hair follicle stem cells. In 2018, Pelage Pharmaceuticals licensed the intellectual property to PP405 and related topical small molecules from UCLA. Information on the Phase 2a study can be found on ClinicalTrials. gov.

Hi, Been going down the PP405 rabbit-hole recently. The mechanism behind the drug is really promising imo. I think it has the potential to really be a significant and effective therapy for some people. Truthfully however, I have yet to see anything from the 2a trial that has truly wowed me. Like that statistic: ‘31% of those treated with PP495 so a 20% increase in hair density’ is a bit of a nothing burger to me. Like we don’t know long term how the drug is going to fair. Anyways, this brings me to my question. Have there been any other ‘miracle drug’ stories out there that never met the hype?