The reasoning why Generic GH =/= Pharma

[GreatGhandi51]

Hi guys i havent posted this anywhere on the internet genuinely wanted to keep it to myself as was a mission to get this compiled.

This is the reason why alot of people always state theirs night and day difference between pharma and generic. Im still one to say generic is poison, i cant stand it.

The Chinese have been able to duplicate everything, but GH there purity levels are still not that, and in a rRNA based compound 1% causes huge changes.

Generic siladfeil = Viagra, generic paracetamol = Panadol but generic GH =/= serostim why?


The above should give you bit of clarity as to the situation.

E coli is purified after having 191aa placed in it to duplicate, hgh and by product (Notably: HMW). And as far as i know HMW should show in purity of GH if im not mistaken (so wont show up in inmpurity but part of GH)

HMW is whats causing the unwanted bloat and not clean feeling your getting ie headaches and hard headed (where as pharma doesnt do that). The impurities is what cause the red welts and so forth.

So whilst you may have a 97% testing gh, IGF are high.. but the bloat and 'headacheness' etc make it not worth it.

The reason the chinese arent getting 99% is because i asked one supplierr it cost alot and loss of product, and as you know CN; $$$. If people are buying shit and you can get away with it? why not.




This is the reason for the problems; mind you this was compiled after going datbtrues work and Janoshik work. To the average layman he wouldn't know the difference (as he just bloats up and thinks it good), but seasoned vets can tell you straight away.

Also i dont want to go into too much detail but since were talking, there was a famous gh seller on this forum. It was rumoured to be the best GH of all time, do you know why that is? because he had a individual working at one of CN's top GH producing plants and was ripping the company off to release it into black-market. You werent getting 'good generic' you were just getting relabelled pharma at generic price.


Maybe in a few years when they start hitting 99% purity etc, but for now... eh if IGF numbers with the bloat and headache is worth it. Thats up to you.

 

[romo]

I see what you are saying. And its probably somewhat true. This debate has come up many times, pharm v generic we understand. Price is a big one. I know one thing i sure have been enjoying my TPs blacks for the past 6 years.

 

[GreatGhandi51]

I see what you are saying. And its probably somewhat true. This debate has come up many times, pharm v generic we understand. Price is a big one. I know one thing i sure have been enjoying my TPs blacks for the past 6 years.

I just wanted to post for people like juanB etc, as they always want a scientific reasoning. And there really hasn't been one. Even jano thinks generics rival 95% pharma etc, i say thats a mistake. Because id rather have degenerated pharma then 97% generic... night and world difference.

 

[luki7788]

I have never had a single negative side effect that you are writing about here, even after 20iu generic

 

[GreatGhandi51]

I have never had a single negative side effect that you are writing about here, even after 20iu generic

yeh bro i noticed some people (very few) dont seem to be affected but like for example jm425 whose respected here with his ailments cannot use generics. So your lucky my brother.

 

[Treadstone71]

I have never had a single negative side effect that you are writing about here, even after 20iu generic

You have good genetics to handle these compounds. Not everyone is as fortunate however.

 

[liv2pb]

I don't get any of these negative side effects either. Now, I've never had pharm grade but generics have been a gamechanger for me.

 

[GreatGhandi51]

I don't get any of these negative side effects either. Now, I've never had pharm grade but generics have been a gamechanger for me.

One you try pharrma you will know what i mean bro. Night and world diff; the 3d look, fat loss etc all non mitigated by that super rannoying thickness of water from generics (gh has water dont get me wrong but not to that extent).

 

[traininsane11]

I would imagine everyone would opt for pharma over generic IF the cost wasn’t so wildly different and the chances of it being faked being way higher with pharma than generic. Can’t speak for anywhere other than the UK but for as long as I can remember the amount of fake “pharma” gh made it to risky and costly

I do notice water rentention quite severely off generics (never tried pharma so could be the same)

 

[GreatGhandi51]

I would imagine everyone would opt for pharma over generic IF the cost wasn’t so wildly different and the chances of it being faked being way higher with pharma than generic. Can’t speak for anywhere other than the UK but for as long as I can remember the amount of fake “pharma” gh made it to risky and costly

I do notice water rentention quite severely off generics (never tried pharma so could be the same)

yeh bro; different people different results (try pharma atleast once in your life.. see if you notice a difference)

I created this thread because there was 204 pages of pro muscle userrs discussing x/y/z

https://www.professionalmuscle.com/forums/index.php?threads/hgh-testing.118858/page-209

but no one could actually pinpoint the issue, i have a background in medicine/pharmacy so took me a while to peice all the above together, but remembererd the boys on here trying to seek the truth.

Hopefully itll get to them.

 

[Zamun]

Picking your brain.. do you feel this way strictly about GH or do you feel the same toward other UGL compounds test/nand whatever.

 

[KingOfSushi]

HMW is whats causing the unwanted bloat and not clean feeling your getting ie headaches and hard headed (where as pharma doesnt do that). The impurities is what cause the red welts and so forth.

I’ve seen plenty of people use pharma gh straight from cvs get these symptoms still. These are known side effects of taking growth hormone even in the pharmaceutical world.

 

[GreatGhandi51]

Picking your brain.. do you feel this way strictly about GH or do you feel the same toward other UGL compounds test/nand whatever.

Everything else beautiful, generic TE = exact same compound as organon TE. There straight compounds, but 191 amino acid in perfect structure... well you tell me.

 

[MajinBoo]

Have used different pharma GH's in the past (saizen, norditropin, geno,...) and have been using only generic GH for the last two years and, more than not having any negative side effects, I have never noticed that difference.
In addition, in contrast to what was mentioned, I hear way more people (including seasoned BB's) saying they don't see the difference either. Who reports that difference is a minority.

 

[GreatGhandi51]

I’ve seen plenty of people use pharma gh straight from cvs get these symptoms still. These are known side effects of taking growth hormone even in the pharmaceutical world.

Oh dont get me wrong, gh has these sides. But for example the mental fog on pharma (just feels like your tired teenager waiting for your sleep) whereas generic feels like a rock, doesnt happen in the first 1-2 shots but 3 days in... and f** thats why i call it poison LOL

 

[GreatGhandi51]

Have used different pharma GH's in the past (saizen, norditropin, geno,...) and have been using only generic GH for the last two years and, more than not having any negative side effects, I have never noticed that difference.
In addition, in contrast to what was mentioned, I hear way more people (including seasoned BB's) saying they don't see the difference either. Who reports that difference is a minority.

Yes brother; thats why it a 50/50 with the generic thing. Im giving the reasons to the people that complain its not the same and what the reason is.

 

[KingOfSushi]

Oh dont get me wrong, gh has these sides. But for example the mental fog on pharma (just feels like your tired teenager waiting for your sleep) whereas generic feels like a rock, doesnt happen in the first 1-2 shots but 3 days in... and f** thats why i call it poison LOL

I mean I’ve never experienced that personally but alright

 

[primobolan]

I have used both. This is yet another instance in bodybuilding and much like the current "scientific" training methods being pushed where the science does NOT always equal real world results. This does not mean the OP is incorrect, on paper it's all there but we live in the real world and results do not lie. The UGL GH I am currently running (which is not Chinese based) is exactly the same as the few different pharma products I have used, two of which were pharmacy direct. I have watched the quality of the underground become better and better for the past 20 years. This has been debated and beaten to death and the waters have been mudded on both sides from guys with financial gain from either end. I have no skin in the game just 30 years of experience. Save your money.

 

[FakeName123]

As far as I'm concerned buying pharma gh online = buying Chinese generic gh put into pharma containers

And it's not like Chinese generic are made in a basement.... they're made in the same multi million dollar factories pharma is made in from my understanding, since it requires that large of a facility to even be made in the first place

 

[Sectør]

I mean technically pharma gh allows up to 4% dimer if I’m not mistaken.

And with some generics testing around 98% purity with no dimer nowadays, I mean I think the difference is negligible.

Some pharma hgh even has excipients in it that act as a diuretic, so I don’t think the bloat comparison is entirely fair in the pharma vs generic debate.

Basically with pharma you’re paying exponentially more due to the rigorous quality assurance testing it has to go through


The rest is from AI with regards to the quality assurance testing pharma hgh has to go through


1. Identity Tests

• Peptide mapping / Mass spectrometry / HPLC: Confirms that the protein is indeed somatropin.
• Amino acid sequence and molecular weight verification
• Isoelectric focusing (IEF): Checks the isoelectric point to ensure it’s the correct isoform.

2. Purity and Impurities

• Size-Exclusion Chromatography (SEC): Detects dimers, oligomers, aggregates.
• Reversed-Phase HPLC: Measures protein-related impurities.
• SDS-PAGE and Western blot: Evaluates the presence of degradation products or incomplete proteins.
• Host cell protein (HCP) content: Ensures residual E. coli or CHO proteins (depending on the expression system) are minimal.
• DNA contamination: Residual host DNA must be below strict limits (e.g., <10 ng/dose).

3. Microbial & Endotoxin Testing

• Sterility test: Must show absence of bacteria or fungi (per USP <71>).
• Bacterial endotoxins (LAL test): Must be below 5 EU/kg body weight/hour, commonly <0.5 EU/mg in somatropin.
• Mycoplasma testing (if produced in cell culture).

4. Heavy Metals & Elemental Impurities

• ICP-MS or AAS analysis: Tests for elemental impurities like:
  • Lead (Pb)
  • Arsenic (As)
  • Cadmium (Cd)
  • Mercury (Hg)
• Must comply with ICH Q3D guidelines for permissible daily exposure (PDE) levels.

5. Potency Assay (Bioactivity)

• In vitro cell-based assays (e.g., proliferation of 3T3 or Nb2 cells)
• In vivo bioassay (e.g., weight gain in hypophysectomized rats — less common today)
• Confirms biological activity aligns with labeled potency (e.g., 10 IU = ~3.33 mg).
  
  6. Water Content and Residual Solvents
  • Karl Fischer titration (for lyophilized formulations)
  • GC or HPLC for detecting residual solvents (per ICH Q3C)
• • 7. pH, Osmolality, and Visual Inspection
  • 
    
  • pH of the reconstituted solution must fall within specified range.
  • Osmolality measured for injectable formulations.
  • Visual check for particulates, color, or clarity issues.
• 
  
  
  8. Stability and Shelf-Life Testing
  • Accelerated and real-time stability testing under various conditions (ICH Q1A).
  • Tests to see if the product remains within specifications