The reasoning why Generic GH =/= Pharma

[mexbeast]

Thats because both were pharma and from the same place. Ps: your the only one to get it, feel free to read all of sven's posts for more info.

https://www.uk-muscle.co.uk/threads/hygetropin-controversy-settled-the-facts.209579/page-2

That's what i figured, TP circa 05 or so

 

[Knight9]

so you trusted the manufacturer and didn't check it yourself - I just wanted to know

I'm sorry where were you in 2012-2014?
Not even here.

I respect you but let's try to put testing now vs testing then in perspective and understand those two were the most trusted in the business at the time. In 2016, due to curiosity...I decided to go pharma and from my experience, never looked back..

 

[URODA]

Thats because both were pharma and from the same place. Ps: your the only one to get it, feel free to read all of sven's posts for more info.

https://www.uk-muscle.co.uk/threads/hygetropin-controversy-settled-the-facts.209579/page-2

Yeah so you clearly played yourselves here reading through conversation he mentioned the difference experienced changing from what you say came pharma (thinking was only generic) to "real" pharma cheers

 

[luki7788]

I'm sorry where were you in 2012-2014?
Not even here.

I respect you but let's try to put testing now vs testing then in perspective and understand those two were the most trusted in the business at the time. In 2016, due to curiosity...I decided to go pharma and from my experience, never looked back..

man but why are you upset I just asked if you checked it yourself and not what year it was and it doesn't matter that testing wasn't so common back then - it doesn't change the fact that people just blindly trusted someone - I learned not to trust absolutely anyone until the end, especially when money is involved

that's all - no stress

 

[Knight9]

man but why are you upset I just asked if you checked it yourself and not what year it was and it doesn't matter that testing wasn't so common back then - it doesn't change the fact that people just blindly trusted someone - I learned not to trust absolutely anyone until the end, especially when money is involved

that's all - no stress

Because the way you said it, the sponsors mentioned...and perspective in relation to the timeline matter.
No big deal I just wanted to paint the full and clear picture to you and others reading.

 

[GreatGhandi51]

Yeah so you clearly played yourselves here reading through conversation he mentioned the difference experienced changing from what you say came pharma (thinking was only generic) to "real" pharma cheers

My job is just to educate the public bro (as i know alot of old veterans are reading and know 'truth' when they see it).

There is no difference between all pharm grade, weather saizen/omnitrope/hygetropin/jintropin. They all go through rigorous and strict testing to maintain purity and quality. Some bodybuilders will tell you they might feel a tad bit different on one company compared to other, but its all the same shit.

The same cannot be however said about generics hence me quoting jm425. 191aa in perfect 3d structure is hard to replicate, esp since all the Chinese care about is $$ not your health, tell me then why not one CN producer has 'thought outside of the box' and produced generic IGF?

The problem and i feel with alot of bodybuilders on the net; is alot of 'assumption' based tren-68778-hydra new compound bla bla and they get side-tracked with all the fancy talk, when 'reality does not reinforce the theory behind it' and this is the problem with generics, 'my guy has 5655% over-dosed 10iu' but you inject it, 2-3 days later you have the worlds biggest headache and cannot function.

If you cannot afford it and want the IGF spurt go with generics, if you want health and clean compound go with pharma.

 

[URODA]

My job is just to educate the public bro (as i know alot of old veterans are reading and know 'truth' when they see it).

There is no difference between all pharm grade, weather saizen/omnitrope/hygetropin/jintropin. They all go through rigorous and strict testing to maintain purity and quality. Some bodybuilders will tell you they might feel a tad bit different on one company compared to other, but its all the same shit.

The same cannot be however said about generics hence me quoting jm425. 191aa in perfect 3d structure is hard to replicate, esp since all the Chinese care about is $$ not your health, tell me then why not one CN producer has 'thought outside of the box' and produced generic IGF?

The problem and i feel with alot of bodybuilders on the net; is alot of 'assumption' based tren-68778-hydra new compound bla bla and they get side-tracked with all the fancy talk, when 'reality does not reinforce the theory behind it' and this is the problem with generics, 'my guy has 5655% over-dosed 10iu' but you inject it, 2-3 days later you have the worlds biggest headache and cannot function.

If you cannot afford it and want the IGF spurt go with generics, if you want health and clean compound go with pharma.

Please check the message you responded to and the entire conversation the person you were quoting said he used what you say was clearly pharma unknowingly then changed to known pharma continuing to say how there was difference showing obviously placebo cheers

 

[KingOfSushi]

Yeah so you clearly played yourselves here reading through conversation he mentioned the difference experienced changing from what you say came pharma (thinking was only generic) to "real" pharma cheers

Just curious, is English your first language?

 

[KingOfSushi]

There is no difference between all pharm grade, weather saizen/omnitrope/hygetropin/jintropin

This is not accurate at all

 

[sandiego_2008]

In one of Chase Irons youtube videos on generic hgh, there was a very interesting comment from someone claiming to be a protein chemist. I copied his response and asked chapgpt to interpret & this was the answer regarding genetic vs pharma:

———-

The comment in your image is from someone claiming to be a protein chemist with over a decade of industry experience and 2 years of analytical chemistry experience. Here’s a breakdown of what they’re saying about generic vs pharmaceutical HGH (human growth hormone)—specifically somatropin:

















Summary of the Key Points:











1.


Formulation Process:

• The HGH products being discussed are initially formulated as liquids, then lyophilized (freeze-dried) into powder in vials.
• The final formulation of the buffer (the solution in which the protein is dissolved) affects the stability of the HGH.
• Improper shipping or storage conditions can also impact HGH stability after it’s reconstituted (mixed back into liquid).

2.


Testing of Generic HGH:

• The person performed SDS-PAGE (a lab method for protein sizing) on Chinese generic HGH samples.
• No degradation or aggregation was observed (meaning the proteins looked mostly intact).
• However, there was a 1–3 kDa shift in molecular weight—this suggests a difference in size, possibly due to alternate isoforms or mutations.

3.


Isoforms and Bioactivity:

• The comment references UniProt accession P01241, which relates to somatotropin (HGH).
• There are different isoforms of HGH, and isoforms 2 and 3 may have missense point mutations (amino acid changes).
• While these mutations are thought not to affect bioactivity, there are no formal studies confirming that.
• Pharmaceutical-grade HGH uses isoform P01241-1, which has a canonical molecular weight of 22 kDa.

4.


Chinese Generic HGH Findings:

• The generic version tested had a mass of 20 kDa instead of 22 kDa.
• This may indicate:
  • A truncated form
  • An isoform variation
  • Possibly a non-identical sequence

5.


Detection via HPLC:

• HPLC (High-Performance Liquid Chromatography) can detect both the 20 kDa and 22 kDa forms.
• Both would be identified as hGH, but the difference in mass might point to lower purity, altered bioactivity, or manufacturing inconsistency.

Interpretation:

• Pharma-grade HGH is highly consistent, using the standard isoform of 22 kDa.
• Chinese generics may contain alternative forms of HGH, such as slightly shorter or modified proteins, likely to save costs or due to looser manufacturing standards.
• These differences could theoretically affect potency, stability, immunogenicity, or effectiveness, even if some isoforms retain bioactivity.
• There is no strong clinical data confirming whether these variants are equally effective or safe.

Bottom Line:

• The commenter is highlighting a quality and consistency gap between pharmaceutical-grade and generic (especially Chinese) HGH.
• While both may “work,” the generic version may be inferior or inconsistent at the molecular level.
• This is particularly important if you’re using HGH for clinical, anti-aging, or performance purposes where precise dosing and purity matter.

 

[KingOfSushi]

In one of Chase Irons youtube videos on generic hgh, there was a very interesting comment from someone claiming to be a protein chemist. I copied his response and asked chapgpt to interpret & this was the answer regarding genetic vs pharma:

———-

The comment in your image is from someone claiming to be a protein chemist with over a decade of industry experience and 2 years of analytical chemistry experience. Here’s a breakdown of what they’re saying about generic vs pharmaceutical HGH (human growth hormone)—specifically somatropin:

















Summary of the Key Points:











1.


Formulation Process:

• The HGH products being discussed are initially formulated as liquids, then lyophilized (freeze-dried) into powder in vials.
• The final formulation of the buffer (the solution in which the protein is dissolved) affects the stability of the HGH.
• Improper shipping or storage conditions can also impact HGH stability after it’s reconstituted (mixed back into liquid).

2.


Testing of Generic HGH:

• The person performed SDS-PAGE (a lab method for protein sizing) on Chinese generic HGH samples.
• No degradation or aggregation was observed (meaning the proteins looked mostly intact).
• However, there was a 1–3 kDa shift in molecular weight—this suggests a difference in size, possibly due to alternate isoforms or mutations.

3.


Isoforms and Bioactivity:

• The comment references UniProt accession P01241, which relates to somatotropin (HGH).
• There are different isoforms of HGH, and isoforms 2 and 3 may have missense point mutations (amino acid changes).
• While these mutations are thought not to affect bioactivity, there are no formal studies confirming that.
• Pharmaceutical-grade HGH uses isoform P01241-1, which has a canonical molecular weight of 22 kDa.

4.


Chinese Generic HGH Findings:

• The generic version tested had a mass of 20 kDa instead of 22 kDa.
• This may indicate:
  • A truncated form
  • An isoform variation
  • Possibly a non-identical sequence

5.


Detection via HPLC:

• HPLC (High-Performance Liquid Chromatography) can detect both the 20 kDa and 22 kDa forms.
• Both would be identified as hGH, but the difference in mass might point to lower purity, altered bioactivity, or manufacturing inconsistency.

Interpretation:

• Pharma-grade HGH is highly consistent, using the standard isoform of 22 kDa.
• Chinese generics may contain alternative forms of HGH, such as slightly shorter or modified proteins, likely to save costs or due to looser manufacturing standards.
• These differences could theoretically affect potency, stability, immunogenicity, or effectiveness, even if some isoforms retain bioactivity.
• There is no strong clinical data confirming whether these variants are equally effective or safe.

Bottom Line:

• The commenter is highlighting a quality and consistency gap between pharmaceutical-grade and generic (especially Chinese) HGH.
• While both may “work,” the generic version may be inferior or inconsistent at the molecular level.
• This is particularly important if you’re using HGH for clinical, anti-aging, or performance purposes where precise dosing and purity matter.

While interesting, I’d question how much legitimate research or data chatgpt has available to grab on generic UGL gh… or whether what IT considers Chinese generics is even the same “generics” we are referring to in a bodybuilding forum context

 

[sandiego_2008]

While interesting, I’d question how much legitimate research or data chatgpt has available to grab on generic UGL gh… or whether what IT considers Chinese generics is even the same “generics” we are referring to in a bodybuilding forum context

Here is the screenshot of the response i’m referring to if that helps to add any context:

 

[madg]

If at first you not succeed.. buy more GH and try again

 

[F350]

I remember it being a “thing” and probably still is that 10iu generic = 5iu pharma

Thats because both were pharma and from the same place. Ps: your the only one to get it, feel free to read all of sven's posts for more info.

https://www.uk-muscle.co.uk/threads/hygetropin-controversy-settled-the-facts.209579/page-2

man thats alot of back and forth. Im not knowledgeable to decipher or even try to keep the name changes straight. Its been a ongoing debate between people since I can remember.
On a side note I used to do work with the jintropin owner directly. Its been almost 20 years so i don't recall everything to a T but his name was either "Lee Jin or Jin Lee" (spelling may be different) if my memory serves me correct. Was always an extremly nice guy. I for some reason thought he did his schooling in the midwest like Wisconsin or Chicago but the two debating seem to say CA so I could be wrong. Its been a while.

 

[mexbeast]

Jintropin, juven, and TP were amazing back in early 2000's I haven't found any other genetics similar to those, but maybe i just don't respond as well any more? Never tried pharma, so i can't compare. It's funny though, i tried some tp's grey tops not to long ago and i wasn't impressed at all, so yeah maybe it's just me

 

[qbkilla]

Just curious, is English your first language?

For his sake I hope not

 

[A50#]

Back in the early 2000's I used to have two connections that I'd buy Serostim kits from. I would literally drive them to the pharmacy at CVS and pick them up. Very good HGH yes indeed but honestly speaking my results were literally no different than MOST of the quality generics I've tried like TPs and Acetropin. A few years back I had a TRT doctor who since has passed away, write me a prescription for Serostim that I used for well over a year and while it was excellent HGH it wasn't worth me paying 4-5 x the amount I was paying versus generics. I've used other pharma brand HGH to like Humatrope and while I'm sure they were legit, I didn't see it come direct from the pharmacy like I did the Serostim.

 

[3BILLS]

I Just use both. Checking all those boxes as the kids would say
To bad my diet is terrible

 

[hawkmoon]

A little bit off topic, but it hits me in another "hobby" of my life - watch collecting.

It wasn't long ago when collectors could not stop crapping on Chinese quality (I'm not talking reps exactly, just capabilities).
Bracelets and cases came up. No one in China could match Swiss finishing on cases and bracelets.

Then they found out Omega and others often have their bracelets and cases made in China then shipped to Switzerland because as long the finished product has a minimum 60% Swiss value (including labor costs) it's Swiss-made.

 

[specter]

Back in the early 2000's I used to have two connections that I'd buy Serostim kits from. I would literally drive them to the pharmacy at CVS and pick them up. Very good HGH yes indeed but honestly speaking my results were literally no different than MOST of the quality generics I've tried like TPs and Acetropin. A few years back I had a TRT doctor who since has passed away, write me a prescription for Serostim that I used for well over a year and while it was excellent HGH it wasn't worth me paying 4-5 x the amount I was paying versus generics. I've used other pharma brand HGH to like Humatrope and while I'm sure they were legit, I didn't see it come direct from the pharmacy like I did the Serostim.

Im the same way man, been in this for almost 20 years tried tons of GH both Pharma, good generics, shitty generics and everything in between.. good generics and pharma GH 0 difference other then cost..