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As always, read and get educated before using ANYTHING, please.
I searched and found this:
"Pharmacia & Upjohn announced that the U.S. Food and Drug Administration has cleared for marketing its prescription drug Genotropin Lyophilized Powder (somatropin [rDNA origin] for injection) for long-term replacement therapy in adults with growth hormone deficiency (GHD) of either childhood or adult onset.
Growth hormone deficiency occurs when the pituitary gland does not secrete sufficient amounts of endogenous growth hormone. Adults may acquire this condition as a result of treatment of pituitary tumors, or from other medical conditions resulting in hypopituitarism; it can also be a continuation of childhood-onset growth hormone deficiency. Growth hormone deficiency should be determined with an appropriate growth hormone stimulation test.
In vitro, preclinical, and clinical studies have demonstrated that Genotropin is therapeutically equivalent to human growth hormone of pituitary origin. In six placebo-controlled clinical studies of 172 GHD adults, 85 of which received Genotropin, lean body mass, total body water, and lean/fat ratio all increased while total body fat mass and waist circumference decreased after six months. These effects on body composition were maintained when treatment was continued beyond six months. Bone mineral density declined after six months of treatment but returned to baseline values after 12 months.
IMPORTANT SENTENCE !!! "Bone mineral density declined after six months of treatment but returned to baseline values after 12 months."
In other words, it is very important to not just STOP using this product, or ANY growth hormone, as it causes bone mass deficiency. It is important to continue using in order to raise baseline values lost over a set course of time. You won't know what is happening to your skeletal system unless you go in for a bone density exam. I would also think high quality calcium and mineral supplements are in order here, too. Remember, though, don't take a calcium supplement with milk, ever! Milk will neutralize the supplement. Take only with water.
There is medical evidence that indicates adults with GHD can benefit from growth hormone replacement therapy - including those previously treated for GHD as children and those who are recognizing this condition for the first time," said Barbara Lippe, M.D., P&U's senior medical director, Peptide Hormones. "Both types of patients can realize physical improvements through therapy with Genotropin, while also having access to a range of patented, patient-friendly devices used to prepare and administer this medicine." For adults, Genotropin is available in two-chamber cartridges containing 5.8 mg and 13.8 mg. Both cartridge sizes may be used with the Genotropin Pen growth hormone delivery devices and the Genotropin Mixer or the pre-assembled Intra-Mix growth hormone reconstitution devices. Treatment is administered six or seven times per week by a subcutaneous injection in the thigh, buttocks, or abdomen. Dosage is adjusted for the individual patient.
In November 1996, Pharmacia & Upjohn submitted a New Drug Application for Genotropin to treat adults with GBD. The product has been in use in Europe to treat adults since 1993 and is available in 28 countries worldwide, including Sweden, Germany, the United Kingdom and Austria. Genotropin for use in treating GHD in children was cleared for marketing in the U.S. in August 1995.
"The new adult indication for Genotropin builds upon our global presence as a leader in growth hormone research and development," said Jack Jackson, senior vice president and president, North American pharmaceutical operations. "Now we can offer U.S. adults with GHD a product that has been used extensively elsewhere in the world, while also making available an array of easy-to-use drug preparation and delivery devices not found elsewhere."
In clinical trials, the most prevalent side effects in GHD adults treated with Genotropin were mild to moderate symptoms of fluid retention, including peripheral swelling, arthralgia, pain and stiffness of the extremities, peripheral edema, myalgia, paresthesia and hypoesthesia. Genotropin should not be used when there is any evidence of neoplastic activity, including intracranial lesions or tumors. Patients with diabetes or glucose intolerance would be monitored closely during treatment with Genotropin.
Treatment with Genotropin should be directed by physicians with experience in the diagnosis and management of patients with GHD."
I searched and found this:
"Pharmacia & Upjohn announced that the U.S. Food and Drug Administration has cleared for marketing its prescription drug Genotropin Lyophilized Powder (somatropin [rDNA origin] for injection) for long-term replacement therapy in adults with growth hormone deficiency (GHD) of either childhood or adult onset.
Growth hormone deficiency occurs when the pituitary gland does not secrete sufficient amounts of endogenous growth hormone. Adults may acquire this condition as a result of treatment of pituitary tumors, or from other medical conditions resulting in hypopituitarism; it can also be a continuation of childhood-onset growth hormone deficiency. Growth hormone deficiency should be determined with an appropriate growth hormone stimulation test.
In vitro, preclinical, and clinical studies have demonstrated that Genotropin is therapeutically equivalent to human growth hormone of pituitary origin. In six placebo-controlled clinical studies of 172 GHD adults, 85 of which received Genotropin, lean body mass, total body water, and lean/fat ratio all increased while total body fat mass and waist circumference decreased after six months. These effects on body composition were maintained when treatment was continued beyond six months. Bone mineral density declined after six months of treatment but returned to baseline values after 12 months.
IMPORTANT SENTENCE !!! "Bone mineral density declined after six months of treatment but returned to baseline values after 12 months."
In other words, it is very important to not just STOP using this product, or ANY growth hormone, as it causes bone mass deficiency. It is important to continue using in order to raise baseline values lost over a set course of time. You won't know what is happening to your skeletal system unless you go in for a bone density exam. I would also think high quality calcium and mineral supplements are in order here, too. Remember, though, don't take a calcium supplement with milk, ever! Milk will neutralize the supplement. Take only with water.
There is medical evidence that indicates adults with GHD can benefit from growth hormone replacement therapy - including those previously treated for GHD as children and those who are recognizing this condition for the first time," said Barbara Lippe, M.D., P&U's senior medical director, Peptide Hormones. "Both types of patients can realize physical improvements through therapy with Genotropin, while also having access to a range of patented, patient-friendly devices used to prepare and administer this medicine." For adults, Genotropin is available in two-chamber cartridges containing 5.8 mg and 13.8 mg. Both cartridge sizes may be used with the Genotropin Pen growth hormone delivery devices and the Genotropin Mixer or the pre-assembled Intra-Mix growth hormone reconstitution devices. Treatment is administered six or seven times per week by a subcutaneous injection in the thigh, buttocks, or abdomen. Dosage is adjusted for the individual patient.
In November 1996, Pharmacia & Upjohn submitted a New Drug Application for Genotropin to treat adults with GBD. The product has been in use in Europe to treat adults since 1993 and is available in 28 countries worldwide, including Sweden, Germany, the United Kingdom and Austria. Genotropin for use in treating GHD in children was cleared for marketing in the U.S. in August 1995.
"The new adult indication for Genotropin builds upon our global presence as a leader in growth hormone research and development," said Jack Jackson, senior vice president and president, North American pharmaceutical operations. "Now we can offer U.S. adults with GHD a product that has been used extensively elsewhere in the world, while also making available an array of easy-to-use drug preparation and delivery devices not found elsewhere."
In clinical trials, the most prevalent side effects in GHD adults treated with Genotropin were mild to moderate symptoms of fluid retention, including peripheral swelling, arthralgia, pain and stiffness of the extremities, peripheral edema, myalgia, paresthesia and hypoesthesia. Genotropin should not be used when there is any evidence of neoplastic activity, including intracranial lesions or tumors. Patients with diabetes or glucose intolerance would be monitored closely during treatment with Genotropin.
Treatment with Genotropin should be directed by physicians with experience in the diagnosis and management of patients with GHD."
