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Time off GH to restore IGFBP-3?

Elvia1023

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I just noticed your heart enlargement thread. I would have thought that would be reason enough to stay away from HGH.
 

dale338

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I am also interested in this. I've read more and kore about developing an immune response with prolonged use and no breaks. Especially with generic Chinese GH, which I use. I'm planing to run 4 months on and 1 month off and monitor my IGF-1 numbers closely.
 

asteelz

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You guys over think this .. if there was an innate immune response to gh it would be with all gh , not just generic, and we would see this in patients with acromegaly but it's not the case
 

Thebigone

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This what I was referring to:

"Injectable use of HGH during a one to three month period may increase IGF-1 levels by as much as double or triple the original baseline levels, which commonly will be sustained for up to six months. At that time, an increase in binding proteins and/or the activity of negative feedback loops may reduce levels by 50% to 100% returning to baseline. Patients are recommended to cycle off of injectable therapy for at least two to three weeks, and may resume after the binding proteins (IGFBP-3) have reduced sufficiently to allow restored IGF-1 levels again. It may be appropriate to reduce the dosage after the first few months, to adjust for the negative feedback loop and to avoid cortisol deficiencies."
 

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