transdermal really is not nearly as effective as injection. IMO when you do transdermal the drug hits your system really fast but then the effects dont last very long. it peaks fast and then tapers off really fast so that it doesnt really seem to last even 1 day. Like others have said, the DMSO has a fearsome smell. DMSO has also been proven to be carcinogenic, so a slight risk there I suppose. DMSO leaves your skin red too, almost like a rash. Similar in effect to using Retin A, skin used to get really red and irritated with that. With DMSO youll have to do it every day, and thats a hastle too.