Trevogrumab in Enhanced Bodybuilders — Worth the Risk?

[R3aper7]

Agreed. I can’t even say that GLP’s have translated to better physiques on stage.

But if myostatin inhibitors were the holy grail we would have a different level of bodybuilders on stage already… and we don’t.

I think maybe the increased popularity of the glp drugs is going to translate to quantity of competitors. I think these drugs will serve to reduce some of the most difficult parts of prep, which will eliminate or reduce some of the barriers to the growth of our sport. Whether that’s good or bad, I’m not sure.

 

[dantes]

We heard the same with Increlex it was the "holy grail" bla bla bla.. until some guy steps on stage at 400lbs ripped i aint buyin the sales pitch.. being hyper bole here offcourse.

If one had limitless funds I am sure increlex would be used more as some have reported good results. Just taking a lot of fucking generic GH will also get you there at a fraction of the cost though.

 

[BigKevKris]

10mg a week. It’s about 7k for a descent cycle of it right now

It better be magical at that price

 

[Splitzz]

It better be magical at that price

The guy went up 20lbs and stayed the same bf% the entire run. Seemed magically to me lol.. still stays active for a couple
Months after the last shot

 

[Splitzz]

If one had limitless funds I am sure increlex would be used more as some have reported good results. Just taking a lot of fucking generic GH will also get you there at a fraction of the cost though.

Agreed 20iu of gh and slin will give similar results to increlex

 

[TheOtherOne55]

You never hear about it anymore. Why didn't it become a thing? I assume cost? I feel like I also read reports on boards that guys said when they came off, the look faded that they had on it. I remember back around 2004 lr igf came out and was all hyped too

I still hear about increlex from competitors. I know 2 different guys running it right now. They look great.
Again, i have no idea whether IT is the reason why they are having a great offseason because they are doing lots of other shit. But its not like something that disappeared and no one uses. There are still LOTS of guys (amateurs and pros) who will invest in it and use it. It never disappeared.

The myostatin stuff, trevogrumab, seeeems like it could be the next generation. But again, we are just looking at 1 study with humans (who happen to be obsese and on ozempic) and it looks promising, but not WORLD-CHANGING. We know how this goes, BBers will mess with it and experiment, prices will get lower, MORE guys will experiment, some will swear by it, others will think it was a waste, discussion goes on lol.

 

[mexbeast]

You never hear about it anymore. Why didn't it become a thing? I assume cost? I feel like I also read reports on boards that guys said when they came off, the look faded that they had on it. I remember back around 2004 lr igf came out and was all hyped too

Look at vigorous Steve, he says he has done a couple cycles and look at him now, he looks even smaller. When he claimed to be using it, he didn't blow up!

 

[bbxtreme]

You never hear about it anymore. Why didn't it become a thing? I assume cost? I feel like I also read reports on boards that guys said when they came off, the look faded that they had on it. I remember back around 2004 lr igf came out and was all hyped too

It’s just a bit tougher to get and is very expensive. But if you ask guys like Justin Compton they will tell you it is absolutely a game changer.

 

[bbxtreme]

For the guys looking at trevogrumab — understand what you’re actually messing with which I share objectively.

This isn’t a peptide. It’s a monoclonal antibody that binds to myostatin. That means your immune system can make anti-drug antibodies against it.

If that happens:

• It can stop working
• Your body clears it fast
• You can get inflammatory reactions
• And once you’ve built antibodies, re-running it can hit worse

This isn’t like pulling EQ or mast. It has a very long half-life. If your body doesn’t like it, you’re riding it out.

Most of us are already suppressing myostatin with gear and heavy training anyway. Now you’re stacking a long-acting immune drug on top of that.

I’m not for it or against it. Just sharing my thoughts out loud objectively as I have them. I’ll be the first to follow and watch as others try it.

 

[buck]

The risk to reward at this point makes it a non starter for me. The financial benifits to me would have to be pretty big to make it worthwhile. The ego benefit to a few more pounds of muscle, not so much. If long term data looks good in the future then my opinion could change.

 

[Ha.Ki.Beom]

The regenron study seems a bit underwhelming. But who knows in combination with anabolics and growth.

Mini circle's follasatin looked really good on paper, but it didn't pan out....https://minicircle.io/our-therapies/follistatin/

Jujimufu, MIlos, amongst others took it and nada..

 

[solarsentinel1]

Is this something alleges to work locally like ACE031 or systemically like Follistatin and / or Increlex. Just curious.

 

[bbxtreme]

Is this something alleges to work locally like ACE031 or systemically like Follistatin and / or Increlex. Just curious.

Systemically. It’s a biologic (engineered antibody) that targets myostatin.

Very different MOA and is stronger than Follastatin.

 

[traininsane11]

The guy went up 20lbs and stayed the same bf% the entire run. Seemed magically to me lol.. still stays active for a couple
Months after the last shot

I can do that with a rebound, some gh and insulin but I can GUARANTEE you maybe 1/10th of it is actually muscle at the most lol

Depends on timeline but if we’re talking a few weeks/months I don’t even think the body could gain that in actual lbm and if you did your heart would probs be waving you a fond farewell

 

[bigflex256]

We heard the same with Increlex it was the "holy grail" bla bla bla.. until some guy steps on stage at 400lbs ripped i aint buyin the sales pitch.. being hyper bole here offcourse.

Like Chris aceto said on Rxmuscle….the day we see a 400 lb BB on stage is when they start making humans with 2 aorta’s lol

 

[Fleezy]

Let’s be real

The middle easterners would be winning everything if drugs made as much difference as people think they do

 

[specter]

Like Chris aceto said on Rxmuscle….the day we see a 400 lb BB on stage is when they start making humans with 2 aorta’s lol

yeah there is a human limit