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Trimethylglycine (Betaine Anhydrous) - Liver & Heart Protection

Impact of Betaine on Hepatic Fibrosis and Homocysteine in Nonalcoholic Steatohepatitis - A Prospective, Cohort Study

Effect Decrease
Trial Design Cohort
Trial Length 6+ Months
Number of Subjects 23
Gender Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Body Types Obese, Overweight

Notes for this study:
10g of betaine twice daily over the course of one year in persons with nonalcoholic fatty liver appeared to significantly reduce ALT (), AST (), and ALP () liver enzyme values relative to baseline (no placebo control) with five subjects finding normalization of liver fat.

In an intent to treat analysis, over 90% of subjects reported reductions in liver fat or inflammation in general; 36.4% of subjects who reported benefit to fibrosis scores (11 out of 23) had more than two stages of improvement, and only one subject had a worsening of fibrosis.
 
Betaine, A Promising New Agent For Patients With Nonalcoholic Steatohepatitis: Results Of A Pilot Study

Effect Decrease
Trial Design Cohort
Trial Length 6+ Months
Number of Subjects 7
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight

Notes for this study:
Supplementation of betaine at 500mg twice daily over the course of one year was able to fully normalize liver enzymes in three out of seven patients and reduce them by more than 50% in three others, with one nonresponder and the dropouts (before the year the trial lasted) also noting a 38-39% reduction.
 
Betaine Supplementation Enhances Anabolic Endocrine And Akt Signaling In Response To Acute Bouts Of Exercise

Effect Decrease
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 12
Gender Male
Age Range 18-29
Body Types Trained, Average

Notes for this study:
Supplementation of betaine at 1.25g twice daily for one week appears to, when exercising in a fasted state, increase IGF-1 (7.8%) and reduce cortisol concentrations (6.1%) and nonsignificantly increase growth hormone (6.1%) relative to placebo.

This study noted that the decrease in Akt/P70S6K signalling (anabolic signalling) during exercise was attenuated with betaine, but AMPK was not affected.
 
BETAINE INDUCED RELEASE OF TISSUE FACTOR PATHWAY INHIBITOR AND NITRIC OXIDE: IMPLICATIONS IN THE MANAGEMENT OF CARDIOVASCULAR DISEASE

Effect Increase
Trial Design Cohort
Trial Length 1-7 Days
Number of Subjects 12
Gender Both Genders
Age Range 18-29, 30-44

Notes for this study:
One week supplementation of betaine has been noted to increase nitric oxide levels in plasma by 185% following 6g of oral betaine supplementation, which returned to baseline values immediately following supplement cessation.
 

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