I did one shot a week for my TRT (200mg/wk) for two or three years (almost 5yrs on TRT now). I suffered from higher levels of HCT, RBC, Iron, and maybe a couple of others.
I switched to twice a week shots and saw improvements in those numbers, but still slightly high.
I switched to thrice a week shots and my numbers all showed normal ranges in my latest blood work. I will probably stick with this dosing schedule for the foreseeable future.