Using GH secretagogues (Mk/ghrp/ghrh) and exo GH at the same time ?

[johnjuanb1]

So I assume MK would be fine then? Do you remember the mechanism by which exo GH inhibits the effectiveness of GHRHs? Or a link to that thread

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423324/

Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men.
S M Rosenthal, J A Hulse, S L Kaplan, and M M Grumbach
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Abstract

Previous studies from this laboratory and by others in rats, monkeys, and humans support the concept that growth hormone (GH) can regulate its own secretion through an autofeedback mechanism. With the availability of human growth hormone-releasing factor (GRF), the possible existence of such a mechanism was reexplored by examining the effect of exogenous GH on the GH response induced by GRF-44-NH2 in six normal men (mean age, 32.4 yr). In all subjects the plasma GH response evoked by GRF-44-NH2 (1 microgram/kg i.v. bolus) was studied before and after 5 d of placebo (1 ml normal saline i.m. every 12 h), and then before and 12 h after 5 d of biosynthetic methionyl human GH (5 U i.m. every 12 h). The GH response to GRF (maximal increment over time 0 value) was significantly inhibited after GH treatment (0-1.3 vs. 2.3-11.2 ng/ml before treatment, P = 0.05), but was not significantly affected by placebo. This impaired pituitary response to GRF persisted for at least 24 h following exogenous GH treatment in two subjects who underwent further study. Serum somatomedin-C concentrations were significantly increased after 5 d of GH treatment (2.66-5.00 vs. 0.92-1.91 U/ml before treatment, P = less than 0.01). The impaired pituitary response to GRF may be mediated indirectly through somatomedin, somatostatin, by a direct effect of GH on the pituitary somatotropes, or by all of these mechanisms. These data suggest that after GH treatment, the blunted GH response to synthetic GRF is not solely a consequence of the inhibition of hypothalamic GRF secretion.

 

[liv2pb]

Not combining them together but I'm doing 4iu oranges 4x weekly then mk677 3x weekly.

 

[Biggerp73]

Ok guys I found some cheap MK677 so I am going to try out. I don't want to use it in the morning though because I don't want the hunger pains. So I might just use it at night time. But I run my GH around 3-5pm so I am wondering about the overlap there. Maybe I'll try it out in the morning for a few days to see how it effects appetite. If it didn't cause overeating that would be good because I'd like the GH to be at peak levels when I've got nutrients in my blood stream and I don't always get in a protein meal in the middle of the night.