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- Apr 9, 2021
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There are differences between pharma products in antimicrobial preserve agents and excipients that provide some stability against aggregation, stress such as freezing/incubation/agitation. The active ingredient, Somatropin (rhGH) is either Somatropin or not. It is quite possible to synthesize GHR agonist peptides that lack the torsional force in binding the GHR as rhGH (it is however IMPOSSIBLE to synthesize any polypeptide that activates the GHR with greater torsional force than 22kDa-GH [rhGH]). Still, given market pressures, copycatting of E. coli patented methods for rhGH manufacturing is manyfold times more likely to mean that what a user ends up with in a generic rhGH product is... indeed true rhGH.
So the difference comes down to: quality of the pharma device (i.e., pen, premixed solution, versus having to deal with cheap vial tops, slin pins, etc.) and some considerations surrounding the antimicrobial preserve agents/stabilizers/excipients in pharma preparations.
The major one is this:
Using generic rhGH, one should reconstitute the vial for no more than about a week's worth at a time, to be kept at a sane storage temperature. If one does expose the reconstituted generic peptide to agitation/incubation/freezing, the solution is not resistant to these stressors whereas the pharmaceutical preparations are to some degree.
That's it. Generic rhGH can be as good equimolar concentrations of pharma rhGH (comparing the actual active ingredient, Somatropin), so long as it's treated with just a bit more care, and the user doesn't mind dealing with slin pins and cheap vials.
So the difference comes down to: quality of the pharma device (i.e., pen, premixed solution, versus having to deal with cheap vial tops, slin pins, etc.) and some considerations surrounding the antimicrobial preserve agents/stabilizers/excipients in pharma preparations.
The major one is this:
Using generic rhGH, one should reconstitute the vial for no more than about a week's worth at a time, to be kept at a sane storage temperature. If one does expose the reconstituted generic peptide to agitation/incubation/freezing, the solution is not resistant to these stressors whereas the pharmaceutical preparations are to some degree.
That's it. Generic rhGH can be as good equimolar concentrations of pharma rhGH (comparing the actual active ingredient, Somatropin), so long as it's treated with just a bit more care, and the user doesn't mind dealing with slin pins and cheap vials.