I take it with breakfast , lunch and dinner (about 20 AFTER eating) I use 250mg standard release tabs because I don’t eat a lot of carbs. If I decide to have a big carb meal I can just add in more. I also prefer the shorter action in case I want to use insulin preworkout 3:00-4:00pm , the morning dose is well out of my system by then so there isn’t any chance of the metformin interfering with the insulin protocol.
If I take off for a while (like recently) I have to slowly titrate my dose back up to limit stomach upset. I also find that taking it after eating helps reduce stomach bloating as well. It seems to really slow down gastric emptying for me.