Who's excited for Retatrutide?

[Fat]

What makes Retatrutide unique is that it targets THREE receptors.

Semaglutide targeted the receptor glucagon-like peptide-1 (GLP-1), and Tirzepatide targeted both the GLP-1 receptor and glucose-dependent insulinotropic peptide (GIP) receptor.

This potentially all-powerful weight loss drug tackles GLP-1 and GIP receptors while also targeting the body’s glucagon receptors.

Supposedly, what this does is give the drug a DIRECT effect on energy expenditure (unlike its predecessors).

We effectively have a lowering of appetite from GLP-1, improved fat clearance and stimulate the release of lipoprotein lipase from fat with GIP, and a higher metabolic rate with the glucagon receptor.

Take a look at this early preclinical study done in mice and tell me your mind isn’t BLOWN AWAY:

Tirzepatide is in blue and Retatrutide is in red — not only is the total weight loss significantly larger, but the majority of weight loss is pure fat.

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Pharmacological strategies that engage multiple mechanisms-of-action have demonstrated synergistic benefits for metabolic disease in preclinical models. One approach, concurrent activation of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic ...

www.ncbi.nlm.nih.gov

 

[Virtuous]

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[xx]

very interesting, it is amazing to see how fast they are progressing with these.

 

[juggy38]

Username to post checks out

I fucking laughed out loud in an elevator.

 

[Ranchhand]

I'm intrigued, looking forward to seeing how this group of peptides work out.

 

[Ranchhand]

Username to post checks out

Yeah, got to say that was funny, laughed out loud myself

 

[UnholyAlliance]

Hmm, sounds like the OP wants this one so bad lmao. In all seriousness would this be good for us?

 

[SouthernMuscle]

Does nobody take dnp anymore wtf

 

[Hatchet]

Not me... Ill diet if I need to lose weight...

 

[UnholyAlliance]

Does nobody take dnp anymore wtf

Sounds like people were looking for a safer easier alternative

 

[stackdizzy]

Man I know a lot of people that are pretty happy with Tirzepatide. Can be pricey though so cost would probably be the biggest factor with the two...I imagine

 

[SouthernMuscle]

Sounds like people were looking for a safer easier alternative

Just like anything else, the danger is in the dose

like many, i was scared shitless to try it and never even regarded it as an option. Then someone whose opinion i give a shit about suggested it. Kicking myself in the ass for not considering it sooner. I don’t push the dose though, I’m 260+ right now totally depleted on keto and only use 200mg per day, that‘s baby shit compared to some of these cats lol

 

[cage99]

Just like anything else, the danger is in the dose

like many, i was scared shitless to try it and never even regarded it as an option. Then someone whose opinion i give a shit about suggested it. Kicking myself in the ass for not considering it sooner. I don’t push the dose though, I’m 260+ right now totally depleted on keto and only use 200mg per day, that‘s baby shit compared to some of these cats lol

200mg for me makes feel like absolute dog shit!!!!! Man I don’t like DNP..

Cage

 

[BLang]

Sounds like people were looking for a safer easier alternative

What if I told you, you can do both?

 

[UnholyAlliance]

What if I told you, you can do both?

If that's possible then the best of both worlds.

 

[SouthernMuscle]

200mg for me makes feel like absolute dog shit!!!!! Man I don’t like DNP..

Cage

Oh for sure, me too. That’s why i put it with keto because i hate that shit even more. 2 weeks of feeling shitty, get the results. I just accept it