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Why did people taking DNP die?

DNP is no joke. In the old days, people died because DNP was often contaminated (it was used in the mining industry, and manufactured un-hygienically. Imagine something scooped out of a barrel of mining chemicals!), and people probably didn't measure it as precisely as we can now.

In recent times, it's important to separate fact from urban myth. I swear, I've had no less that two DOZEN (not exaggerated) people gripe at me about DNP issues by claiming they "know a guy" or "had a friend" who died on the stuff. I call bullshit on that. If it were true, it'd be all over the news and the forums; this would be a HUGE medical scandal. To me, "I know a guy who died/almost died on DNP" is the equivalent of "My Great-Grandmother was a Cherokee princess" of cliché claims.

There have been one or two verifiable deaths, and both were in the early-mid 90s. In both cases, the men had combined DNP with street drugs and alcohol (one of them had boasted of this on the Elite forums, in a now-infamous incident). His source was apprehended and served a brief amount of time--not for the death (which everyone, even the authorities, recognized as the victim's own doing), but for marketing a non-approved "dietary supplement." At the heart of it, this is a situation involving people not following rules of common sense and then DELIBERATELY compounding their risks. On its own, the fatal dose of DNP is somewhere around 3 grams per average male. Most men using DNP use 2-3 caps/day, which ranges from less than half a gram to slightly more than half a gram. To take a fatal dose of DNP (without using any other substances to increase the chances of death), one would have to take about 10-15 caps' worth (depending on the dose of the capsules, which are typically 200-250mg). Who does that?

One other issue to watch for are the DNP scare-mongers, who like to say stuff like "You're stupid if you use that shit! They make bug spray/dynamite/the One Ring of Sauron out of that stuff!"

It's technically true that DNP did indeed used to be an ingredient in some pesticides--back in the old days. DNP, although flammable in dry, raw form, is not an ingredient of dynamite, so that's just wrong (Wikipedia is your friend!). But this makes a basic logical mistake: if substance A is used in substance B, and substance B is bad, does that proves that substance A is just as bad, too? Of course not! You never hear people use the same ignorant scare-tactics about injectible AAS: "Bro, that shit contains alcohol! They use alcohol to preserve dead fetal pigs in jars! You're stupid for using a dead fetal pig preservative!"

Or drinking a Mountain Dew: "Bro, that shit contains water! They use water in toilets! You're stupid for using something that flushes turds!"

So the lesson is that what they use something in is NOT insight into the properties of a single separated component of the thing, too.

Funny thing is that when I've occasionally posted the dozens of studies from pubmed (which are verifiable peer-reviewed publications) that show that DNP also fights cancers, shrinks tumors, preserves DNA and RNA, attacks infections, and weakens bacteria that are antibiotic resistant, some people scoff and go right back to that "DNP is dynamite and comes from Satan's anus and I know a guy who grew two heads on the stuff" nonsense.

And I'll admit it: in the past, I too unintentionally repeated misinformation about DNP myself, totally innocently, and was called out for it. I accepted the new information, apologized for repeating something that had been incorrect, and changed my thoughts--which, I believe, is what we're SUPPOSED to do when we make a mistake, right?

So congratulations and much respect to people on PM, who are known for serious inquiry! It's nice to see a discussion that doesn't just devolve back into the typical bodybuilding.com mythology.
 
Oh yeah, and PS: I follow PM's rules. I'm adding to this discussion, not sourcing. Support board sponsors, please.
 
DNP is no joke. In the old days, people died because DNP was often contaminated (it was used in the mining industry, and manufactured un-hygienically. Imagine something scooped out of a barrel of mining chemicals!), and people probably didn't measure it as precisely as we can now.

In recent times, it's important to separate fact from urban myth. I swear, I've had no less that two DOZEN (not exaggerated) people gripe at me about DNP issues by claiming they "know a guy" or "had a friend" who died on the stuff. I call bullshit on that. If it were true, it'd be all over the news and the forums; this would be a HUGE medical scandal. To me, "I know a guy who died/almost died on DNP" is the equivalent of "My Great-Grandmother was a Cherokee princess" of cliché claims.

There have been one or two verifiable deaths, and both were in the early-mid 90s. In both cases, the men had combined DNP with street drugs and alcohol (one of them had boasted of this on the Elite forums, in a now-infamous incident). His source was apprehended and served a brief amount of time--not for the death (which everyone, even the authorities, recognized as the victim's own doing), but for marketing a non-approved "dietary supplement." At the heart of it, this is a situation involving people not following rules of common sense and then DELIBERATELY compounding their risks. On its own, the fatal dose of DNP is somewhere around 3 grams per average male. Most men using DNP use 2-3 caps/day, which ranges from less than half a gram to slightly more than half a gram. To take a fatal dose of DNP (without using any other substances to increase the chances of death), one would have to take about 10-15 caps' worth (depending on the dose of the capsules, which are typically 200-250mg). Who does that?

One other issue to watch for are the DNP scare-mongers, who like to say stuff like "You're stupid if you use that shit! They make bug spray/dynamite/the One Ring of Sauron out of that stuff!"

It's technically true that DNP did indeed used to be an ingredient in some pesticides--back in the old days. DNP, although flammable in dry, raw form, is not an ingredient of dynamite, so that's just wrong (Wikipedia is your friend!). But this makes a basic logical mistake: if substance A is used in substance B, and substance B is bad, does that proves that substance A is just as bad, too? Of course not! You never hear people use the same ignorant scare-tactics about injectible AAS: "Bro, that shit contains alcohol! They use alcohol to preserve dead fetal pigs in jars! You're stupid for using a dead fetal pig preservative!"

Or drinking a Mountain Dew: "Bro, that shit contains water! They use water in toilets! You're stupid for using something that flushes turds!"

So the lesson is that what they use something in is NOT insight into the properties of a single separated component of the thing, too.

Funny thing is that when I've occasionally posted the dozens of studies from pubmed (which are verifiable peer-reviewed publications) that show that DNP also fights cancers, shrinks tumors, preserves DNA and RNA, attacks infections, and weakens bacteria that are antibiotic resistant, some people scoff and go right back to that "DNP is dynamite and comes from Satan's anus and I know a guy who grew two heads on the stuff" nonsense.

And I'll admit it: in the past, I too unintentionally repeated misinformation about DNP myself, totally innocently, and was called out for it. I accepted the new information, apologized for repeating something that had been incorrect, and changed my thoughts--which, I believe, is what we're SUPPOSED to do when we make a mistake, right?

So congratulations and much respect to people on PM, who are known for serious inquiry! It's nice to see a discussion that doesn't just devolve back into the typical bodybuilding.com mythology.

Discussion... over. :D
 
so people who say as well as studies who stated people did Die on DNP

is the study wrong? bogus? not accurate?
if so why
if not
in your oppinion
what did the people taking dnp do wrong

thanks\

I pmed a couple buddies of mine on here and asked their oppinion

just curious about everyone elses?

The simple answer is taking too much.
 
bump

thanks guys for your input
its so nice to see so many people
know wtf they are talking about

BUMP
 
Speaking of serious inquiry...

DNP is no joke. In the old days, people died because DNP was often contaminated (it was used in the mining industry, and manufactured un-hygienically. Imagine something scooped out of a barrel of mining chemicals!), and people probably didn't measure it as precisely as we can now.

In recent times, it's important to separate fact from urban myth. I swear, I've had no less that two DOZEN (not exaggerated) people gripe at me about DNP issues by claiming they "know a guy" or "had a friend" who died on the stuff. I call bullshit on that. If it were true, it'd be all over the news and the forums; this would be a HUGE medical scandal. To me, "I know a guy who died/almost died on DNP" is the equivalent of "My Great-Grandmother was a Cherokee princess" of cliché claims.

There have been one or two verifiable deaths, and both were in the early-mid 90s. In both cases, the men had combined DNP with street drugs and alcohol (one of them had boasted of this on the Elite forums, in a now-infamous incident). His source was apprehended and served a brief amount of time--not for the death (which everyone, even the authorities, recognized as the victim's own doing), but for marketing a non-approved "dietary supplement." At the heart of it, this is a situation involving people not following rules of common sense and then DELIBERATELY compounding their risks. On its own, the fatal dose of DNP is somewhere around 3 grams per average male. Most men using DNP use 2-3 caps/day, which ranges from less than half a gram to slightly more than half a gram. To take a fatal dose of DNP (without using any other substances to increase the chances of death), one would have to take about 10-15 caps' worth (depending on the dose of the capsules, which are typically 200-250mg). Who does that?

One other issue to watch for are the DNP scare-mongers, who like to say stuff like "You're stupid if you use that shit! They make bug spray/dynamite/the One Ring of Sauron out of that stuff!"

It's technically true that DNP did indeed used to be an ingredient in some pesticides--back in the old days. DNP, although flammable in dry, raw form, is not an ingredient of dynamite, so that's just wrong (Wikipedia is your friend!). But this makes a basic logical mistake: if substance A is used in substance B, and substance B is bad, does that proves that substance A is just as bad, too? Of course not! You never hear people use the same ignorant scare-tactics about injectible AAS: "Bro, that shit contains alcohol! They use alcohol to preserve dead fetal pigs in jars! You're stupid for using a dead fetal pig preservative!"

Or drinking a Mountain Dew: "Bro, that shit contains water! They use water in toilets! You're stupid for using something that flushes turds!"

So the lesson is that what they use something in is NOT insight into the properties of a single separated component of the thing, too.

Funny thing is that when I've occasionally posted the dozens of studies from pubmed (which are verifiable peer-reviewed publications) that show that DNP also fights cancers, shrinks tumors, preserves DNA and RNA, attacks infections, and weakens bacteria that are antibiotic resistant, some people scoff and go right back to that "DNP is dynamite and comes from Satan's anus and I know a guy who grew two heads on the stuff" nonsense.

And I'll admit it: in the past, I too unintentionally repeated misinformation about DNP myself, totally innocently, and was called out for it. I accepted the new information, apologized for repeating something that had been incorrect, and changed my thoughts--which, I believe, is what we're SUPPOSED to do when we make a mistake, right?

So congratulations and much respect to people on PM, who are known for serious inquiry! It's nice to see a discussion that doesn't just devolve back into the typical bodybuilding.com mythology.

Here's a few publications to have a look at if anyone is 'serious' about their inquiry. Of course, we all know that people will believe what they want to believe.

I was interested to see that DNP fights cancer. I presume this is because of it's cytotoxicity or is it because it preferentially and selectively induces
cellular oxidation and inhibits phosphorylation in cancer cells vs. regular cells. Amazing if true. Can you post the pub med articles please?

Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill. Bartlett James; Brunner Michael; Gough Katie St Mary's Hospital, Praed Street, London W2 1NY, UK [email protected] Emergency medicine journal : EMJ (2010), 27(2), 159-60. Journal code: 100963089. E-ISSN:1472-0213. England: United Kingdom. (CASE REPORTS); Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 20156878 AN 2010108700 In-process for MEDLINE

Abstract

A 46-year-old man took a lethal dose of an agent called dinitrophenol (DNP). He presented 11 h after ingestion with loin pain, diarrhoea and vomiting. He rapidly deteriorated with profound hyperthermia, acute renal failure, hyperkalaemia, metabolic acidosis and eventually haemodynamic instability. Despite aggressive supportive measures and rapid sequence induction, he deteriorated and died 21 h after ingestion. DNP is a metabolic poison that acts by uncoupling oxidative phosphorylation, leading to uncontrolled hyperthermia. It is an illegal weight loss agent that is used by body builders and is freely available on many internet websites. This case highlights the potential for patients to obtain and ingest exotic poisons. A summary of currently recommended treatment and a review of the literature on DNP is included, as well as a discussion of therapies that may be effective in treating hyperthermia in this situation.

Two Deaths Attributed to the Use of 2,4-Dinitrophenol. Miranda, Estuardo J.; McIntyre, Iain M.; Parker, Dawn R.; Gary, Ray D.; Logan, Barry K. Washington State Toxicology Laboratory, Washington State Patrol, Seattle, WA, USA. Journal of Analytical Toxicology (2006), 30(3), 219-222. Publisher: Preston Publications, CODEN: JATOD3 ISSN: 0146-4760. Journal written in English. CAN 144:383530 AN 2006:297590 CAPLUS

Abstract

We report the cases of two individuals, one in Tacoma, WA, and the second in San Diego, CA, whose deaths were attributed to ingestion of 2,4-dinitrophenol (2,4-DNP). 2,4-DNP has historically been used as a herbicide and fungicide. By uncoupling mitochondrial oxidative phosphorylation, the drug causes a marked increase in fat metab. that has led to its use to aid wt. loss. Both cases reported here involved its use for this purpose. Features common to both cases included markedly elevated body temp., rapid pulse and respiration, yellow coloring of the viscera at autopsy, history of use of wt. loss or body building supplements, and presence of a yellow powder at the decedent s residence. Because of its acidic nature, the drug is not detected in the basic drug fraction of most anal. protocols, but it is recovered in the acid/neutral fraction of biol. exts. and can be measured by HPLC or gas chromatog.-mass spectrometry. The concn. of 2,4-DNP in the admission blood samples of the 2 deaths reported here were 36.1 and 28 mg/L, resp. Death in both cases was attributed to 2,4-DNP toxicity. Review of information available on the internet suggests that, although banned, 2,4-DNP is still illicitly promoted for wt. loss. (c) 2006 Preston Publications.

Dying to be thin: a dinitrophenol related fatality. McFee, R. B.; Caraccio, T. R.; McGuigan, M. A.; Reynolds, S. A.; Bellanger, P. Long Island Regional Poison Control Center, Winthrop University Hospital, Mineola, NY, USA. Veterinary and Human Toxicology (2004), 46(5), 251-254. Publisher: Comparative Toxicology Laboratories, Kansas State University, CODEN: VHTODE ISSN: 0145-6296. Journal written in English. CAN 142:171282 AN 2004:880854 CAPLUS

Abstract

2,4-Dinitrophenol (DNP) was originally used as an explosive and later introduced in the 1930's to stimulate metab. and promote wt. loss. It is also a component of pesticides still available globally. Concerns about hyperpyrexia lead to DNP being banned as a dietary aid in 1938. A 22-y-old male presented to the Emergency Department (ED) with a change in mental status 16 h after his last dose of DNP. On admission he was diaphoretic and febrile with an oral temp. of 102 F, but lucid and cooperative. He became agitated and delirious. I.v. midazolam was initiated with mech. cooling. Pancuronium was administered later and the patient was intubated. Over the next hour the patient became bradycardic, then asystolic, and despite resuscitative efforts, died. Advertisements claim DNP safe at the dose our patient ingested. It is widely available and with the potential to cause severe toxicity is an understudied public health concern.

Be Well.
 

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Sorry to be an idiot, but what board sponsor carries DNP? I am just curious...Thanks
 
I Read a study where some person who was taking dnp back in the day died and the coroner started that even after two days after death the bodys temperture had increased! Crazy!

Asphinctersayswhat? (I want to read this one)
 

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