Finasteride dose for 500 mgs testosterone?

[Love_to_Bodybuild]

Finasteride works by reducing dht levels, systemically and in the scalp.
Those on trt taking it fina at 1 mgs 34d, e3d, eod, or ed, is much different than when raising test

Im guessing experimenting and seeing how everything responds is what to do . See if 1 mg does the trick, if not go up to 2 mgs..

has anyone found a sweet spot dose for themselves while on fina and test?

 

[lif22]

Keep in mind your estrogen will be going up more as a result of less conversion to DHT.

Only advice I could even begin to give would be take average male Total Test of 650 needs about 1mg of fina per day. What is your Total Test after running 500mg and then dose from there. (To make it easy use 1mg fina per every 500ng/DL of total test via blood work)
Very hard to dial all of it in.

 

[Love_to_Bodybuild]

Keep in mind your estrogen will be going up more as a result of less conversion to DHT.

Only advice I could even begin to give would be take average male Total Test of 650 needs about 1mg of fina per day. What is your Total Test after running 500mg and then dose from there. (To make it easy use 1mg fina per every 500ng/DL of total test via blood work)
Very hard to dial all of it in.

Thank you.

Yup ive used test with raloxifene at 25 mgs, and never had issues.

There's got to be a threshold where more isn't better with fina, that said maybe your right maybe do 5 mgs of fina a day. or experiment like we do anyways, try 2,3,4. See how hair does

 

[lif22]

Yes for sure its not linear so upping the dose at some point would probably have diminishing returns. Could always get DHT tested via blood work at various dosages.

 

[Love_to_Bodybuild]

Yes for sure its not linear so upping the dose at some point would probably have diminishing returns. Could always get DHT tested via blood work at various dosages.

Ive done this once before on trt dose.

 

[Kaladryn]

Keep in mind your estrogen will be going up more as a result of less conversion to DHT.

Only advice I could even begin to give would be take average male Total Test of 650 needs about 1mg of fina per day. What is your Total Test after running 500mg and then dose from there. (To make it easy use 1mg fina per every 500ng/DL of total test via blood work)
Very hard to dial all of it in.

Estrogen won't go up form blocking DHT, only a tinny fraction of total testosterone gets converted to E2 or DHT, it's like 1-3% or something, I forget the exact number, but it is extremely small, I've looked it up before. While it is possible small changes in DHT levels could alter the HPGA, and result in E2 changes that way, it wouldn't apply to people using exo-test.

Yes for sure its not linear so upping the dose at some point would probably have diminishing returns. Could always get DHT tested via blood work at various dosages.

DHT that causes hair loss is likely formed inside the skin cell themselves and so serum DHT measurements may be meaningless in this case. This is the rationale behind drug companies making the dosage for finasteride 1mg, when the original study showed that even .2mg was enough to significantly block DHT. I think 1mg is more than enough, even while using lots of exo-test.

 

[lif22]

Estrogen won't go up form blocking DHT, only a tinny fraction of total testosterone gets converted to E2 or DHT, it's like 1-3% or something, I forget the exact number, but it is extremely small, I've looked it up before. While it is possible small changes in DHT levels could alter the HPGA, and result in E2 changes that way, it wouldn't apply to people using exo-test.



DHT that causes hair loss is likely formed inside the skin cell themselves and so serum DHT measurements may be meaningless in this case. This is the rationale behind drug companies making the dosage for finasteride 1mg, when the original study showed that even .2mg was enough to significantly block DHT. I think 1mg is more than enough, even while using lots of exo-test.

If you look at the original Merck studies estrogen did rise with Fina. Even cases of gyno from it. Granted not in everyone but enough to be noted

Your referring to the type 1 (skin, sebum) vs type 2(hair follicle) 5ar enzyme and you are correct which is why dutasteride is more effective for hairloss (allegedly anyway) as it blocks both. But its male castration in my opinion.

 

[Kaladryn]

If you look at the original Merck studies estrogen did rise with Fina. Even cases of gyno from it. Granted not in everyone but enough to be noted

Your referring to the type 1 (skin, sebum) vs type 2(hair follicle) 5ar enzyme and you are correct which is why dutasteride is more effective for hairloss (allegedly anyway) as it blocks both. But its male castration in my opinion.

(edit:I used to be able to find those finasteride studies online but I can't anymore)

If I remember right, E2 rose in those cases from an increase in testosterone levels (due to less negative feedback from DHT) and thus more testosterone to be aromatized, this shouldn't apply to someone taking exogenous testosterone.

Problems with blocking DHT probably come from lowered total androgen activity (DHT has 2x the affinity of testosterone for the AR), I've never tried dutasteride, but I notice that finasteride will slightly lower my sex drive when on TRT, so I don't use it then. But when I cycle, I will often use finasteride and my sex drive is still way too high if it lowered it I would be thankful. The skin can get raw ya know. Ultimately it's your fault, whoever read this far.

 

[Love_to_Bodybuild]

Estrogen won't go up form blocking DHT, only a tinny fraction of total testosterone gets converted to E2 or DHT, it's like 1-3% or something, I forget the exact number, but it is extremely small, I've looked it up before. While it is possible small changes in DHT levels could alter the HPGA, and result in E2 changes that way, it wouldn't apply to people using exo-test.



DHT that causes hair loss is likely formed inside the skin cell themselves and so serum DHT measurements may be meaningless in this case. This is the rationale behind drug companies making the dosage for finasteride 1mg, when the original study showed that even .2mg was enough to significantly block DHT. I think 1mg is more than enough, even while using lots of exo-test.

Thanks for chiming in. I think Ill start here at around 1 mgs. I got the 5 mgs finasteride tablets so I split them four ways, it wont be exact but good enough.

Im on 70-110 mgs a week trt and finasteride even at 0.25 once or twice a week I notice a difference in sex drive and my voice not as deep the day after fina. No big deal though cialis at 2.5 mgs works, and fina with trt, its just a one day. If you got a date that day you could always bump or cialis to 5 mgs. If your feeling frisky 10 mgs, just expect the greater sides than 5 mgs, and for me although 5 mgs has sides its bearable.

 

[Kaladryn]

Thanks for chiming in. I think Ill start here at around 1 mgs. I got the 5 mgs finasteride tablets so I split them four ways, it wont be exact but good enough.

Im on 70-110 mgs a week trt and finasteride even at 0.25 once or twice a week I notice a difference in sex drive and my voice not as deep the day after fina. No big deal though cialis at 2.5 mgs works, and fina with trt, its just a one day. If you got a date that day you could always bump or cialis to 5 mgs. If your feeling frisky 10 mgs, just expect the greater sides than 5 mgs, and for me although 5 mgs has sides its bearable.

I try to get the 5mg tabs also and break them into 1/6ths or 1/8ths

 

[Love_to_Bodybuild]

The "science" if you will behind needing higher doses of finasteride, is that finasteride only inhibits a certain amount of scalp dht and even more systematically.

so say a person does use 500 mgs test and say 1 mgs finasteride a day blocking 60 % of scalp dht, thats still a high percentage of scalp dht , way above normal levels that attack hair follicles.

In the results section- percentages of how much scalp dht it blocks. It appears 1 percent does close to the percent of 5 %.

https://www.ncbi.nlm.nih.gov/pubmed/10495374

 

[Love_to_Bodybuild]

I try to get the 5mg tabs also and break them into 1/6ths or 1/8ths

yep I use it even like 1/12th very small amount when on 10 mgs trt just once or twice a week, esp when I go up to 20 mgs a day.

 

[PoptartPsycho]

Are people experiencing side effects of going with a low dose of 1mg here?

The sides are what keep me from wanting to use it.

 

[Kaladryn]

The "science" if you will behind needing higher doses of finasteride, is that finasteride only inhibits a certain amount of scalp dht and even more systematically.

so say a person does use 500 mgs test and say 1 mgs finasteride a day blocking 60 % of scalp dht, thats still a high percentage of scalp dht , way above normal levels that attack hair follicles.

In the results section- percentages of how much scalp dht it blocks. It appears 1 percent does close to the percent of 5 %.

https://www.ncbi.nlm.nih.gov/pubmed/10495374

That is the study I was referring to, anything above .2mg has a very limited beneficial effect, good find.

 

[Love_to_Bodybuild]

That is the study I was referring to, anything above .2mg has a very limited beneficial effect, good find.

This was in , I assume , guys that have normal testosterone levels ? and not using synthetic and/or higher doses.

I'd like to see lab work on guys on say 500 mgs and oral finasteride, finasteride doses, and what scalp dht measured as.


For now its all we have so, at least we have this.

 

[lif22]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/

Conclusions: During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.