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Old 03-29-2014, 11:09 AM
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Melanotan 2 for summer

I wrote this awhile back but thought I would post for anyone interested as summer is approaching

Melanotan II

Melanotan 2 (MT2) is a synthetic cyclic heptapeptide that is mainly used to increase tanning. It stimulates a natural increase in melanin production. Melanin is the main determinant of skin color in humans. Melanin is a brown pigment which causes skin to become darker in appearance when exposed to UV rays.

Melanotan II was first synthesized at the University of Arizona when looking at possible ways to treat skin cancer. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure.

Clinical trials have shown that Melanotan 2 safely promotes melanogenesis. This is a process were melanocytes produce melanin. Lighter-skinned people have low base levels of melanogenesis. Exposure to UV-B radiation causes an increased melanogenesis. The purpose of the melanogenesis is to protect the hypodermis, the layer under the skin, from the UV-B light that can damage it. It does this by absorbing all the UV-B light and blocking it from passing the skin layer.

I have conducted my own research on the tanning effects of MT2. My own clinical trials have displayed the fast and pronounced effects MT2 has on promoting melanogenesis. MT2 is a very powerful drug in this regard and results have been seen with as alittle as 100mcg daily injected subcutaneously. Results increased in a dose dependent manner during my experiments. However side effects were seen in my testers at higher dosages. As a result I feel the optimal dosing range for future clinical trials would be 250-500mcg daily.

MT2 has also been shown to have aphrodisiac effects. Giuliano F et al. (2006) showed MT2 exerting a dose-dependent effect on erections in anesthetized rats. They went on to show MT2 having inducer and facilitator activities on erection depending upon delivery route of the peptide. There are various studies showing similar results in both animals and humans. Wessells H et al. (2000) highlighted the positive effect MT2 has on sexual desire and erections in men suffering with erectile dysfunction and various organic risk factors.

Through clinical research it has been shown MT2 has excellent fat burning effects. It was previously thought that it assisted weight loss indirectly due to its appetite-reducing effect. However, it now appears that MT2 has direct fat burning effects. Strader AD et al. (2007) is a great example of the direct fat burning effect. They conducted a series of tests including one that shown MT2 treatment led to a general reduction in both visceral and subcutaneous fat tissue in high-fat-fed mice. Choi YH et al. (2003) also showed in addition to reducing food intake and inhibiting body weight gain, administration of MT2 reduces fat mass. They concluded this was most likely by accelerated lipid mobilization, but not by apoptosis (cell death).

A very interesting effect MT2 brings about is it's ability to increase insulin sensitivity during researchers trials. Heijboer AC et al (2005) studied the effects MT2 has on hepatic and whole-body insulin sensitivity. Results showed administration of MT2 increased insulin-mediated glucose disposal but did not affect the capacity of insulin to suppress EGP. MT2's acute effect on insulin sensitivity was further highlighted during studies done by the Nagoya University Graduate School of Medicine. Banno R et al. (2007) examined the effects MT2 had on insulin sensitivity in diet-induced obese rats. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MT2 group compared to the pair-fed group. Furthermore, MT2 treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MT2 increased insulin sensitivity through action on the white adipose tissues.

Side effects are usually observed when MT2 is researched. The most common noticed usually in the early stages of clinical trials are:
Nausea and decreased appetite, flushing of the face, tiredness and yawning, spontaneous erections (males).
These should disappear over a short space of time. Although I recommend bed time dosing to minimize certain side effects. An anti histamine is very useful 1 hour before injection. Ginger root is a natural anti-histamine and anti-emetic so is great for this purpose.

Less common side effects during longer trials include:
Darkening of lips, darkening of freckles, increased libido (females).
If you wanted to minimize these effects I would recommend using a lower dose. For the darkening of lips a high strength sun block should be used as a preventative measure.

References

1. Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J (2006) Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. PMID: 16360286 [PubMed - indexed for MEDLINE]
2. Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA, Baile CA (2003) MTII administered peripherally reduces fat without invoking apoptosis in rats. PMID: 12834806 [PubMed - indexed for MEDLINE]
3. Strader AD, Shi H, Ogawa R, Seeley RJ, Reizes O (2007) The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents. PMID: 17567964 [PubMed - indexed for MEDLINE]
4. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y (2007) Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. PMID: 17321524 [PubMed - indexed for MEDLINE]
5. Heijboer AC, van den Hoek AM, Pijl H, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP (2005) Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. PMID: 15971058 [PubMed - indexed for MEDLINE]
6. Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N (2000) Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. PMID: 11018622 [PubMed - indexed for MEDLINE].



When I start MT2 I start with as little as 50mcg. The way I look at it is it means no horrible nausea etc. Even 100mcg can bring about a dark tan. I would stay around 100mcg for at least a week. Then slowly move up to a max of about 250-400mcg. 250mcg will give you a dark tan and if you move up slowly side effects should be minimal. Obviously the higher you go the darker you go but the chances of side effects increase. No one needs to be injecting 1mg... throwing away money.

Here is a pic (years old) of me on mt2... I am naturally pale white so the difference is huge



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  #2 (permalink)  
Old 03-29-2014, 11:15 AM
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Nice summary. Had good results myself, I unfortunately freckle and while some became darker, no moles like I had initially feared.


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  #3 (permalink)  
Old 03-29-2014, 11:47 AM
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Quote:
Originally Posted by beedix View Post
Nice summary. Had good results myself, I unfortunately freckle and while some became darker, no moles like I had initially feared.


Sent from my iPad using Tapatalk HD
Thanks. I have taken MT2 quite a lot. A few times I have freckled badly off it. But the darker I got the less you could see them. Every time I stopped injecting though all the new freckles/moles disappeared over time. Starting off low and moving up slowly will definitely minimize potential freckling. Moreover not going above 250mcg should prevent freckles/moles. But some are more sensitive and even with a low dose they could get them bad. It's all about experimenting. Once I got a massive one on the tip of my nose that looked bad but it disappeared after I stopped. MT2 is one of my fav things though... I love the fact my stubble goes dark on it too... better than brown and ginger

I want to mention Ginger root again as it is a good supplement to take if you get bad nausea from even small doses of MT2. It's also a good anti-inflammatory, great for gastrointestinal issues and has been shown to increase testosterone levels. It may not be for everyone but I find it is good supplement but if you start off very low with MT2 it will never be needed.
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  #4 (permalink)  
Old 03-29-2014, 12:21 PM
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Good Lord!!!! I thought you were making a joke and posted a pic of an African- American guy. Hahaha....now that's what I call a good tan!!!
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Old 03-29-2014, 12:23 PM
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MT-2 is awesome
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  #6 (permalink)  
Old 03-29-2014, 12:29 PM
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Quote:
Originally Posted by johnjuanb1 View Post
Good Lord!!!! I thought you were making a joke and posted a pic of an African- American guy. Hahaha....now that's what I call a good tan!!!
Here is a pic of me about 22 years old and my natural colour haha...



That first pic doesn't even do it justice. Look at my hand in the first pic. I was on holiday in Turkey though so that's why I was so dark. I was at the bar and some women next to me said she was shocked when I spoke cos she thought I was foreign (her words). Everyone at home said I wasn't tanned but more I had changed my race I don't usually care about appearance but I miss being that tanned. I might ask Superior for some MT2
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  #7 (permalink)  
Old 03-30-2014, 09:09 PM
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OMG what a freaking difference!!!
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  #8 (permalink)  
Old 03-30-2014, 11:34 PM
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Quote:
Originally Posted by PEPTIDES-CHEMS View Post
OMG what a freaking difference!!!
I researched it once a couple yrs ago. Still get tanner than I did. Might research it again this spring.
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Old 03-31-2014, 02:05 AM
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What is the minimum purity I should use?
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  #10 (permalink)  
Old 03-31-2014, 04:55 AM
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Quote:
Originally Posted by Seabiscuit Hogg View Post
I researched it once a couple yrs ago. Still get tanner than I did. Might research it again this spring.
Definitely worth a go especially with the hotter weather coming

Quote:
Originally Posted by Saizen View Post
What is the minimum purity I should use?
MT2 is fairly easy to make so I have never had a bad batch and I have used quite a few sellers over the years. I would imagine all sellers on here have good MT2. I would look for the high 90's when it comes to purity.
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  #11 (permalink)  
Old 04-01-2014, 10:29 AM
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Quote:
Originally Posted by Elvia1023 View Post
Here is a pic of me about 22 years old and my natural colour haha...



That first pic doesn't even do it justice. Look at my hand in the first pic. I was on holiday in Turkey though so that's why I was so dark. I was at the bar and some women next to me said she was shocked when I spoke cos she thought I was foreign (her words). Everyone at home said I wasn't tanned but more I had changed my race I don't usually care about appearance but I miss being that tanned. I might ask Superior for some MT2
...

Does he inject you or do you inject him?


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  #12 (permalink)  
Old 04-01-2014, 11:43 AM
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I've been debating this... 25% off sure does sound appealing.
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Old 04-01-2014, 11:47 AM
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shit I wanna try it now
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Old 04-01-2014, 12:37 PM
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Quote:
Originally Posted by Smack View Post
...

Does he inject you or do you inject him?


He saw that pic recently and said wtf was I doing
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Old 04-01-2014, 12:41 PM
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Quote:
Originally Posted by pj250 View Post
shit I wanna try it now
You should matey just be careful if you do and start of very low like I suggest as it can make you feel very sick if you start high. To sum it up... it's gets you really tanned, gives you rock hard erections, increases slin sensitivity and darkens stubble... miracle drug
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Old 04-01-2014, 10:45 PM
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I need to stock back up on some m2. It took me to a whole other level of darkness.
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Old 04-01-2014, 11:13 PM
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Quote:
Originally Posted by workhard2121 View Post
I need to stock back up on some m2. It took me to a whole other level of darkness.
x2

I have been meaning to pm you. Did you ever try out that stuff?
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Old 04-01-2014, 11:21 PM
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Do you have to store the powder in the freezer?
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Old 04-01-2014, 11:29 PM
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Quote:
Originally Posted by Elvia1023 View Post
x2



I have been meaning to pm you. Did you ever try out that stuff?

Yes brother and holy shit! Meant to message you but with traveling back to the easy coast I completely forget. Talk about looking crazy for some photos. I must say if one wants to look vascular as can be they have to give it a whirl. I will get a pick up for it. Thanks a lot buddy. Was using m2 also, so looked pretty tan :-)
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Old 04-02-2014, 12:30 AM
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Quote:
Originally Posted by Saizen View Post
Do you have to store the powder in the freezer?
I just store mine in the fridge. I had had stuff in the there for well over a year and it was just as strong as the 1st vial. Once I had mt2 mixed in the fridge for at least 6 months and it was super strong so I never really go by some of the things you read online.

Quote:
Originally Posted by workhard2121 View Post
Yes brother and holy shit! Meant to message you but with traveling back to the easy coast I completely forget. Talk about looking crazy for some photos. I must say if one wants to look vascular as can be they have to give it a whirl. I will get a pick up for it. Thanks a lot buddy. Was using m2 also, so looked pretty tan :-)
Great matey
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