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  #1 (permalink)  
Old 10-21-2019, 03:14 PM
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Arterial Plaque and Diet and Supplements

Can diet and/ or supplements reduce arterial plaque??
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  #2 (permalink)  
Old 10-21-2019, 07:10 PM
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Think there is a thread about this, from nothuman or mynameisjeff.

What do you exactually mean by reducing? Reducing the rate that plaque is building up or reducing the plaque that's already there?

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Old 10-21-2019, 08:17 PM
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REDUCING THE PLAQUE THAT IS ALREADY THERE
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  #4 (permalink)  
Old 10-21-2019, 11:15 PM
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Pomegranate Juice can help reduce existing plague levels and keep the plague from forming.
Google it
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  #5 (permalink)  
Old 10-21-2019, 11:45 PM
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Pomegranate extract supps.


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  #6 (permalink)  
Old 10-22-2019, 12:28 AM
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Just keep in mind that Pomegranate Juice can affect other medications, just like Citrus Bergamot.


Carbamazepine (Tegretol) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down carbamazepine (Tegretol). This might increase the effects and side effects of carbamazepine (Tegretol).

Medications changed by the body (Cytochrome P450 2C9 (CYP2C9) substrates
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the body. Pomegranate might decrease how quickly the body breaks down some medications. Taking pomegranate along with some medications that are changed by the body can increase the effects and side effects of your medication. Before taking pomegranate, talk to your healthcare provider if you take any medications that are changed by the body.

Some medications that are changed by the body include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).

Medications changed by the body (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the body. Pomegranate might decrease how quickly the body breaks down some medications. Taking pomegranate along with some medications that are changed by the body can increase the effects and side effects of your medication. Before taking pomegranate, talk to your healthcare provider if you take any medications that are changed by the body.

Some medications that are changed by the body include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), fluoxetine (Prozac), ondansetron (Zofran), tramadol (Ultram), and others.

Medications changed by the body (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the body. Drinking pomegranate juice might decrease how quickly the body breaks down some medications. Drinking pomegranate juice and taking some medications that are broken down by the body can increase the effects and side effects of some medications. Before drinking pomegranate juice, talk to your healthcare provider if you are taking any medications that are changed by the body.

Some medications changed by the body include amlodipine (Norvasc), diltiazem (Cardizem), verapamil (Verelan, Calan, others), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase), alfentanil (Alfenta), fentanyl (Sublimaze), midazolam (Versed), ondansetron (Zofran), propranolol (Inderal), and many others.

Medications for high blood pressure (ACE inhibitors)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Pomegranate juice seems to lower blood pressure. Taking pomegranate juice along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.

Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Pomegranate seems to lower blood pressure. Taking pomegranate along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.

Rosuvastatin (Crestor)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Rosuvastatin (Crestor) is broken down by the body in the liver. Drinking pomegranate juice might decrease how quickly the liver breaks down rosuvastatin (Crestor). This might increase the effects and side effects of rosuvastatin (Crestor).

Tolbutamide (Orinase)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tolbutamide (Orinase) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down tolbutamide (Orinase). This might increase the effects and side effects of tolbutamide (Orinase).

Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Warfarin (Coumadin) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down warfarin (Coumadin). This might increase the effects and side effects of warfarin (Coumadin).
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  #7 (permalink)  
Old 10-22-2019, 02:35 AM
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The ASTEROID trial showed regression of arterial plaque through high dose statin to lower LDL pretty low.

https://www.ncbi.nlm.nih.gov/m/pubmed/16533939/

LDL c was lowered pretty severely; I think mean levels were 60 mg/DL. HDL was increased as well; mean levels at the end were 49 mg/DL after the therapy.


If we’re talking numbers for changes occurred:

“. The mean (SD) change in PAV for the entire vessel was -0.98% (3.15%), with a median of -0.79% (97.5% CI, -1.21% to -0.53%) (P<.001 vs baseline). The mean (SD) change in atheroma volume in the most diseased 10-mm subsegment was -6.1 (10.1) mm3, with a median of -5.6 mm3 (97.5% CI, -6.8 to -4.0 mm3) (P<.001 vs baseline). Change in total atheroma volume showed a 6.8% median reduction; with a mean (SD) reduction of -14.7 (25.7) mm3, with a median of -12.5 mm3 (95% CI, -15.1 to -10.5 mm3) (P<.001 vs baseline). “

I’m not sure how people felt during this trial; no adverse events recorded but some common sides of statin use were present im sure.


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  #8 (permalink)  
Old 10-22-2019, 03:10 AM
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I'm not sure you will find anything that reverses atherosclerosis (in the form of supplements) but but it seems Vitamin K2 can slow progression.

Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in non-dialyzed patients with chronic kidney disease stage 35 (Kurnatowska I, et al) - K2 Vitamin

https://www.lifeextension.com/Magazi...See-It/Page-01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585988/

More reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459726/
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Last edited by Swifto; 10-22-2019 at 03:16 AM.
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  #9 (permalink)  
Old 10-31-2019, 02:23 PM
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1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678830/

2. The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI/APOE double knockout mice.

Al-Jarallah A1, Igdoura F, Zhang Y, Tenedero CB, White EJ, MacDonald ME, Igdoura SA, Trigatti BL.


Author information

1Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4L8.
Abstract

OBJECTIVES:

To examine the effects of pomegranate extract on inflammation and oxidative stress and the development of spontaneous occlusive coronary artery atherosclerosis in the SR-BI/apoE double knockout mouse model of coronary heart disease.

METHODS AND RESULTS:

SR-BI/apoE double KO mice were treated for two weeks with pomegranate extract via drinking water, beginning at three weeks of age. Treatment with pomegranate extract increased cholesterol ester content and reduced the abnormally high unesterified/esterified cholesterol ratio of VLDL-sized lipoproteins. Despite the increase in cholesterol levels associated with VLDL-sized particles, pomegranate extract treatment reduced the size of atherosclerotic plaques in the aortic sinus and reduced the proportion of coronary arteries with occlusive atherosclerotic plaques. Treatment with pomegranate extract resulted in substantial reductions in levels of oxidative stress and monocyte chemotactic protein-1 in atherosclerotic plaques in the aortic sinus and coronary arteries. In addition, treatment with pomegranate extract reduced lipid accumulation, macrophage infiltration, levels of monocyte chemotactic protein-1 and fibrosis in the myocardium, attenuated cardiac enlargement and the development of ECG abnormalities in SR-BI/apoE double KO mice.

CONCLUSION:

Pomegranate extract reduced aortic sinus and coronary artery atherosclerosis in SR-BI/apoE dKO mice. The atheroprotective effects of pomegranate extract appear to involve reduced oxidative stress and inflammation in the vessel wall despite unaltered systemic markers of inflammation and increased lipoprotein cholesterol in these mice.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PMID: 23528829 DOI: 10.1016/j.atherosclerosis.2013.02.025
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  #10 (permalink)  
Old 11-02-2019, 04:09 AM
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Your best bet is regular and consistent cardiovascular exercise.


Tadalafil/cialis has been shown to reverse endothelial damage in mice or rodents, so likely chance in humans.


Vitamin K2 has some research suggesting it may even reverse plaque and arterial stiffness.
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Old 11-02-2019, 04:38 AM
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Waiting on future tech nanites to go in there and eat all my arterial plaque.
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Old 11-06-2019, 02:38 PM
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Pure EPA is another good one.
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Old 11-07-2019, 10:17 PM
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First of all, are you sure you have early signs / stages of atherosclerosis? I had a nuclear medicine stress test performed and everything came back "normal". I said "normal for my age" and they said "normal as in it looks really good." So, as others have said, best you can do is preventative. Take the necessary steps to ensure it doesn't get worse.
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Old 11-07-2019, 11:30 PM
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Also,


High BP and high HCT/HGB is linked to atherosclerosis as well.
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Old 11-08-2019, 05:41 AM
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iv lipostable
supposed to be legit!
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Old 11-10-2019, 02:40 AM
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I left a pretty long post on this thread with links to the studies that got deleted during the site maintenance....
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Old 11-10-2019, 09:49 AM
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Very curious

Has anyone had a before and after coronary CT before starting a supplement regiment in anticipation of plaque regression?

Not that I'm underpinning any of these supplements, moreso curious of your findings.
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Old 11-10-2019, 10:20 AM
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Quote:
Originally Posted by Stewie View Post
Has anyone had a before and after coronary CT before starting a supplement regiment in anticipation of plaque regression?



Not that I'm underpinning any of these supplements, moreso curious of your findings.


Gonna go that route when I have enough under my belt for plaque to show [emoji51]

Same thing can be said about pre and post bloods being pulled for all sorts of things guys take


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Old 11-10-2019, 01:35 PM
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Quote:
Originally Posted by Stewie View Post
Has anyone had a before and after coronary CT before starting a supplement regiment in anticipation of plaque regression?

Not that I'm underpinning any of these supplements, moreso curious of your findings.
I've wondered this too, great question, Stewie! Same for me....just for curiosity of differences.
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Old 11-11-2019, 05:53 PM
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Quote:
Originally Posted by DOGGCRAPP View Post
I left a pretty long post on this thread with links to the studies that got deleted during the site maintenance....
repost plz? ur wisdom is worth its weight in gold, dante. prob my fave thread on this site is ur "things that interest me..." thread and all the great heart health stuff u got in there (not to mention all the other great contributions uve made on health and training over the yrs).
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