spread out the dosage throughout the day and see how long it floats around in your system. Deff sucks laying in bed anxious if you take a dose too late. You might develop a tolerance rather quickly so id suggest dosing mon-fri, and take a benadryl Sat and Sunday night to keep your receptors fresh. - If someone knows where to find the article that highlights this specific science behind the histamine receptors please feel free to chime in. Stay safe and good luck.