HGH has been used by varying groups for therapeutic reasons for some time now. Many peptides are still being studied and we don't know what, if anything negative, could come from using some of them. Of course we know that increasing growth hormone levels can come with side effects, but we don't know yet if using something like cjc or some of the ghrp's could cause separate problems. When the pituitary is hit with a signal to release HGH, is it ok if it isn't the normal endogenous signal? Or is that bad somehow? And the frequency, etc etc. HCG is said to potentially desensitize leydig cells, making leutinizing hormone less effective. Will peptides do this to the pituitary? Or worse? Hopefully not, but we should take into consideration the possible risks of things that are newer, we just don't know yet.