need advice with gyno

[Youngguns22]

I ran a cycle of pheraplex last winter and about 2 months after the cycle i got gyno. Im sure that it came about bc of the pheraplex but im not sure why it was so delayed. I know i should have taken nolva as soon as it started but i didnt. I would like to try to eliminate it now and i saw big A recommend 80mgs/day nolva for 10 days. I have a pct coming up in a week from a test/eq cycle and i was planning on running nolva at 40mgs/day week 1, 30mgs/day week 2 and 20mgs/day week 3. My question is can i run nolva at 80mgs/day the first 10 days of my pct and then resume the pct i planned picking up on day 11 with 30mgs/day or should i run the pct as planned and try the 80mgs/day sometime after the pct is over? Thanks for any help.

[Dad]

Unfortunately, gyno is the actual growth of breat tissue. Yuo won't be able to get rid of what you've got now without surgury, but you can prevent gain any more breast tissue by using Nolvadex, and an aromatase inhibitor like Arimidex.

These two compounds work through entirely different mechanisms, so make a good combination to eliminate the excess estrogen that causes the gyno.

[Youngguns22]

I realize that most likely i will not be able to get rid of the gyno but from reading a little about it on here it seems like a could try a few things before resulting to surgery. Dad, i dont mean to sound like an idiot but im confused by your message. Are telling me to combine arimidex and nolva?

[Dad]

Yes - nolvadex is Selective Estrogen Receptor modulator (SERM), which is just a fancy way of saying that it's a drug that competes with estrogens for receptor binding sites. Thus it blocks estrogen from being able to bind to estrogen receptors.

Aromatase inhibitors like Arimidaex, keep androgen like AAS from being converted to estrogen. This is a process called aromatization, and uses the aromatase enzyme to convert androgens to estrogen as part of the process to eliminate them. By inhibiting the aromatase enzyme, we keep estrogen form ever being formed.

So, one (nolvadex) blocks the estrogen that's there from binding, the other (arimidex) keeps estrogen from being formed from androgens. Thus they make a great combination!

[xcelbeyond]

Nolvadex is from the "anti-estrogen"(anti-e) group. These attach to the receptor sites (nipples and nuts) and prevent excess estrogen from attaching there.

Armidex, letrozole and exemstane are from the "aromatase inhibitor"(AI) group. They do not allow test to convert to estrogen.

[alan1973]

won't Proviron help if I can't get A-dex fast enough?

[Dad]

Proviron will bind to estrogen receptor sort of the way nolvadex does. It's a weaker binding, though.

Yuo can't really compare proviron to arimidex because proviron is simply a competitive binder at estrogen receptors, while arimidex inhibits the aromatase enzyme that converts androgens to estrogen.

[xcelbeyond]

Originally Posted by alan1973

won't Proviron help if I can't get A-dex fast enough?

While arimidex is an AI, I believe an AI won't help if you have signs of gyno, which means test has converted to estrogen already. But there have been anecdotal cases where anastrozol and letrozol help shrink pre-existing gyno - Ry Roid (one of Big A's former mods) had this happen with letrozole.