Aldactone, mannitol

[ScorpioGirl]

I am wondering about aldactone first. I was told that it was something a woman could use in conjunction to a cycle if she were to try one. Apparently this person stated that it would lessen the potential virilization issues.

Also, what is mannitol and why do people use it?

 

[oldfella]

I am wondering about aldactone first. I was told that it was something a woman could use in conjunction to a cycle if she were to try one. Apparently this person stated that it would lessen the potential virilization issues.

Also, what is mannitol and why do people use it?

I have never had any experience with Aldactone, all I do know is it is a diuretic. it has quite a few unwanted sides including Gynaecomastia. Not that is a major concern for you but. Another according to MIMS (pharmacists desk ref)other sides are menstrual irregs and libido changes amongst others. So for Avioding virilisation effects I would put a big question mark there!

Mannitol is also a form of baby laxative. It is also a favorite cutting agent to mix with cocaine. It is used as filler for some other meds and is reasonably harmless. It's primary use is in prep for things like colonoscopy and bowel obstruction . Do not know why it would have a use in our sport for reasons other than the obvious just stated.

 

[Dad]

Mannitol is actually used as what's termed an "osmotic diuretic." Many diuretics work by blocking sodium re-absorption at some point in the nephron tubule - thiazides, loop diuretics, our old friend Lasix, all work like this.

An osmotic diuretic works by increasing the osmotic load on the kidney, dragging water out with it as the kidney tries to dilute this load (a greatly simplified explanation).

The same osmotic effect happens to diabetics when glucose transporters in the kidney become saturated, then overwhelmed. Glucose is dumped in the urine, water follows it, and both glucose and water are lost in urine.

 

[ScorpioGirl]

Mannitol is actually used as what's termed an "osmotic diuretic." Many diuretics work by blocking sodium re-absorption at some point in the nephron tubule - thiazides, loop diuretics, our old friend Lasix, all work like this.

An osmotic diuretic works by increasing the osmotic load on the kidney, dragging water out with it as the kidney tries to dilute this load (a greatly simplified explanation).

The same osmotic effect happens to diabetics when glucose transporters in the kidney become saturated, then overwhelmed. Glucose is dumped in the urine, water follows it, and both glucose and water are lost in urine.

Excellent explanation, Dad! Thank you

 

[eviltemptress]

i researched a bit on this the other day and found the same info dad posted regarding it being an osmotic diuretic, but the only thing i could find that would make it undesirable is that everything i've seen says it's to be administered via IV. could not find any info stating it was in any other form such as tabs or IM inj. or even sub q inj.

 

[Future]

I am wondering about aldactone first. I was told that it was something a woman could use in conjunction to a cycle if she were to try one. Apparently this person stated that it would lessen the potential virilization issues.

Also, what is mannitol and why do people use it?

Here you go dork...

Aldactone is a diuretic and belongs to the subgroup of potassium--sparing diuretics. Aldactone is an aldosterone antagonist. It influ-ences the body's own hormone, aldosterone, which accelerates the excretion of potassium and reduces the excretion of sodium and water. Simplified, aldosterone regulates the endogenous water household. The higher the aldosterone level, the more water is stored in the body. The use of Aldactone results in a significant reduction in the aldosterone level so that an increased excretion of sodium and water occurs while, at the same time, potassium is reabsorbed. This also explains why Aldactone is called a potassium-sparing diuretic since it does not cause a loss of potassium like thiazides and furosemides (lasix) do. Athletes must strictly observe that during the use of Aldactone no additional potassium is taken since this would cause a life-threatening increase in the serum potassium level. Potassium--sparing diuretics have relatively low diuretic effects so that Aldactone can be called a mild diuretic. It is interesting to note that Aldactone is also an antiandrogen since it reduces the androgen level. Female athletes take advantage of this characteristic by using it to mini-mize the virilization symptoms during steroid treatment or the symptoms after treatment. For this purpose Aldactone is normally taken daily for 10 to14 days, usually in a dose of 50 mg/day. In men this could cause problems since the relationship of the andro-gen level to the estrogen level changes in favor of the latter. Thus, common side effects in men include pain in the nipples and breast swelling (gynecomastia).

Bodybuilders use Aldactone almost exclusively during the last week before a competition. Since this causes neither a dramatic nor an immediately noticeable draining effect, it is usually taken over 5-6 days in a dosage of 2 tablets of 50 mg daily. Both male and female athletes take it. The main problems in men consist of gynecomastia and possible impo-tence. Other side effects can be low blood pressure, muscle spasms, dizziness, gastrointestinal pain, vomiting, irregular pulse rate, and fatigue.

Aldactone by Boehringer Mannheim of Germany is often found on the black market. A package contains 50 dragees of 50 mg each and costs approx. $30 on the black market. There are currently no Aldactone fakes available.

 

[didifit]

Wow! just a quick note, In Mexico you can buy Aldactone in a pharmacy for only $17 USD the box contains 30 tablets of 25mg. and also comes in 100mg.
The lab is Pfizer and like you said they are definately not fake.

 

[Future]

i researched a bit on this the other day and found the same info dad posted regarding it being an osmotic diuretic, but the only thing i could find that would make it undesirable is that everything i've seen says it's to be administered via IV. could not find any info stating it was in any other form such as tabs or IM inj. or even sub q inj.

Read that. Was told by a nurse that its not bioavailable to take orally for sure. And the manitol will pull water from the muscle cell as well.