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Receptors explained in layman terms

Dr. Noe

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Aug 19, 2012
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207
Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptorsites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up
hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger,fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the
cook, who would in-turn make the food and the waitress would then bring the food to you and you would thenbegin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to knowabout the receptor sites because they do the exact same thing. We will keep with this hamburger stand model andexplain what happens when you inject steroids and they begin to go to work.

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is
basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are
sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you
were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can
place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger
stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and
place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your
cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the
system because they previously only dealt with what your body naturally produced. However, there are lots of
extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally
impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the
Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different
steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as
testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not
necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space
even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of
"DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the
receptor spaces, if they are already taken up by old "dead cars" you are **** out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED
NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were
sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no
longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors
parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES
PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in
new muscle mass!

O.K. Trevor, I am with you so far, but what the **** can I do about it?

The answer is ...PLENTY!

First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a
fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in
which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself
and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is
"too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars"
you will have sitting in the receptor parking spaces which means NO MORE GROWING!

Now with this in mind, how can we help get the cars out of there?

Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking
spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time
in this situation which is why it is important to utilize short courses that will cause less disturbance in the system,
less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up
the spaces.

That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give
yourself an extended clean out of 2 months at least once a year.

But Trevor, isn't there anything I can do to help speed the process?

Once again the answer is yes!

You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate
is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!

Have you ever know a person who was much, much fatter than you and yet ate half as much?

These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat.
Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was
shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand
this, you can easily control your weight for the rest of your life. But what the **** does this have to due with
steroid receptor sites?

EVERYTHING!

The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I
would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE
METABOLIC RATE!!

Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing
the completion of a Muscle Building Course using anabolics:

Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic
regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the
number of meals you eat, the more your body has to go to work and break down the food which causes the
metabolic rate to increase.

Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per
week 30 minutes per session.

Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time
period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you
embark on this 4 week receptor clearing cycle....otherwise you are wasting your ****ing time! That being said, I
would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:

1. D.N.P. -- Understand that this is a ****ing vicious poison and a component in T.N.T., and I do not suggest it's
use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is
well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the
following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken
before bed----have plenty of towels around and a fan to keep you cool!
2. Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps
you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it
increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course

3. B.M.R. 10--I know, I know shameless plug right...well I don't care, in the past 3 weeks since this product has
been released I have people calling me and emailing me telling me that this product blows the doors off every other
thermogenic including, E/C/A, Clenbuterol and Cytomel, and Tenuate.....People actually think I put D.N.P. in this
product. Trust me I did not, but I did formulate a product with 11 Basil Metabolic Rate increasing compounds that
will make you hotter than an oven and melt the fat right off you. Again in this course we are more concerned with
the metabolic increase this product will cause. Why hasn't anyone else come up with this formula...#1 All the other
companies market to the general public which causes them water down there products #2 it is too expensive for
their profit minded companies to justify it's production #3 They are not bodybuilders, I am and I know what works
and what doesn not.

Doses: On the days you are NOT using D.N.P. have 4 caps before each of the first 5 meals.

* If you do not wish to use D.N.P.---which I think is the smarter approach as it is very dangerous---you cansimply use the B.M.R. 10 on the days that you would be using D.N.P. In my opinion this is smarter, safer and will be
just as effective.

There you have it...a brief simple lesson on your receptors and how you might go about keeping them free and
clear so you can continue to Grow, Grow, Grow
 
I'd be happy to debunk all that and explain how it really thought to work, but it would take too much time to do for for free. Lots of gross misunderstandings, and old theories that have since been disproved in there. Anyone reading should pretty much forget everything they read.

Also worth mentioning, although I could explain the current theory (at least that I'm up to date on), a lot of it is in fact just that, theory. Even among organic chemists, there is considerable debate on many of these theories.
 
I'd be happy to debunk all that and explain how it really thought to work, but it would take too much time to do for for free. Lots of gross misunderstandings, and old theories that have since been disproved in there. Anyone reading should pretty much forget everything they read.

Also worth mentioning, although I could explain the current theory (at least that I'm up to date on), a lot of it is in fact just that, theory. Even among organic chemists, there is considerable debate on many of these theories.


Maybe just a short debunk? I would love to see you tear this apart with actual knowledge and science.
 
I'd be happy to debunk all that and explain how it really thought to work, but it would take too much time to do for for free. Lots of gross misunderstandings, and old theories that have since been disproved in there. Anyone reading should pretty much forget everything they read.

Also worth mentioning, although I could explain the current theory (at least that I'm up to date on), a lot of it is in fact just that, theory. Even among organic chemists, there is considerable debate on many of these theories.


I didn't read all that was erroneously said. If this would of touched on the mechanisms of gene transcriptional activation by steroid hormone nuclear receptors and binding globulins in the actions of steroids and identifying a membrane-associated receptor for a binding protein. It would be a little more intriguing.
 
I didn't read all that was erroneously said. If this would of touched on the mechanisms of gene transcriptional activation by steroid hormone nuclear receptors and binding globulins in the actions of steroids and identifying a membrane-associated receptor for a binding protein. It would be a little more intriguing.

Agreed, and that is just to get started, what about receptor upregulation, co-binding factors, hormone-receptor complex modifying transcription, active vs passive transport across the cell membrane.

I'm not an expert in this stuff, but I have read enough to know these basics. A lot of this stuff is annoying because they know it exists but don't even understand exactly how it works (co-binding factors is a good example of this).
 
This guy was such a fat fuck (show me one picture of him with his shirt off) and then he died when he wasnt even 40. Yeah sure someone will say it was "Genetic" but im sure the obesity didnt help him too much either :banghead:

Its sad that some 22 year old reads this crap and actually believes it.
 
Help with a little basic info please....

I'm sure I'm not alone in saying that some of us would benefit a great deal with the more experience/educated guys on this subject and more. If you guys could take just a few minutes and give a basic understanding of what to do in order to make each cycle the most beneficial many of us would appreciate your help greatly. I know I've made mistakes in how my "reset" times are for receptors.

Thanks guys...
 
I'm sure I'm not alone in saying that some of us would benefit a great deal with the more experience/educated guys on this subject and more. If you guys could take just a few minutes and give a basic understanding of what to do in order to make each cycle the most beneficial many of us would appreciate your help greatly. I know I've made mistakes in how my "reset" times are for receptors.

Thanks guys...

Here is the biggest factor in a nutshell, receptor up-regulation: this is where the number of AR receptors inside the cell multiply. This has two main effects, first it allows the utilization of greater amounts AAS, because there are more receptors to be filled. Second, it DECREASES the effect of AAS, because to reach "maximum anabolism" more total receptors must be filled.

Example, one guy has been off for 6 months and starts taking 200mg of test per week. All his receptors are filled (because there aren't that many) and he is getting great results. After a while, the number of receptors he has doubles, and now only half of his receptors are filled. His gains will slow or even stop.

Having more receptors doesn't mean you will get greater results from higher doses, it means you need more hormone to keep getting the SAME result.

This topic was covered extensively on misc.fitness.weights back in the early/mid 90s by Dan Duchaine, Patrick Arnold, and others.

Keep in mind that there are an enormous number of other factors that could play a greater role than receptor proliferation, such as co-binding factors, active vs passive transport across the cell membrane, post-AR mediated effects (glucocorticoid receptor antagonism). Just to mention a few.
 
Thanks for taking the time to write that kal.
 
Here is the biggest factor in a nutshell, receptor up-regulation: this is where the number of AR receptors inside the cell multiply. This has two main effects, first it allows the utilization of greater amounts AAS, because there are more receptors to be filled. Second, it DECREASES the effect of AAS, because to reach "maximum anabolism" more total receptors must be filled.

Example, one guy has been off for 6 months and starts taking 200mg of test per week. All his receptors are filled (because there aren't that many) and he is getting great results. After a while, the number of receptors he has doubles, and now only half of his receptors are filled. His gains will slow or even stop.

Having more receptors doesn't mean you will get greater results from higher doses, it means you need more hormone to keep getting the SAME result.

This topic was covered extensively on misc.fitness.weights back in the early/mid 90s by Dan Duchaine, Patrick Arnold, and others.

Keep in mind that there are an enormous number of other factors that could play a greater role than receptor proliferation, such as co-binding factors, active vs passive transport across the cell membrane, post-AR mediated effects (glucocorticoid receptor antagonism). Just to mention a few.



thank you for this Kaladryn.. so would going on a cruise dose (say around 200mg/week of test E) reduce the amount of receptors that we have so that when we go back on a blast, the aas will be more effective?
 
thank you for this Kaladryn.. so would going on a cruise dose (say around 200mg/week of test E) reduce the amount of receptors that we have so that when we go back on a blast, the aas will be more effective?

Great question! I have been researching this very thing and have seen several theories. One such is the inclusion of an androgen to increase SBGH such as proviron or masteron. Another is to drop AAS dosages to decrease follistatin or myostatin. I am unsure and would like to hear his take on this as well!
 
thank you for this Kaladryn.. so would going on a cruise dose (say around 200mg/week of test E) reduce the amount of receptors that we have so that when we go back on a blast, the aas will be more effective?

There is no doubt that you become more sensitive to AAS after a cruise. This is why the BEST TALENT you can have is learning how to maintain muscle mass on a low dose cruise. If you learn to do this, you will end up larger on lower amounts than someone who stays on all the time.
 
There is no doubt that you become more sensitive to AAS after a cruise. This is why the BEST TALENT you can have is learning how to maintain muscle mass on a low dose cruise. If you learn to do this, you will end up larger on lower amounts than someone who stays on all the time.



you are the man Kaladyn, thank you very much.


one final question, a cruise should be around 8 week right?
 
Here is the biggest factor in a nutshell, receptor up-regulation: this is where the number of AR receptors inside the cell multiply. This has two main effects, first it allows the utilization of greater amounts AAS, because there are more receptors to be filled. Second, it DECREASES the effect of AAS, because to reach "maximum anabolism" more total receptors must be filled.

Example, one guy has been off for 6 months and starts taking 200mg of test per week. All his receptors are filled (because there aren't that many) and he is getting great results. After a while, the number of receptors he has doubles, and now only half of his receptors are filled. His gains will slow or even stop.

Having more receptors doesn't mean you will get greater results from higher doses, it means you need more hormone to keep getting the SAME result.

This topic was covered extensively on misc.fitness.weights back in the early/mid 90s by Dan Duchaine, Patrick Arnold, and others.

Keep in mind that there are an enormous number of other factors that could play a greater role than receptor proliferation, such as co-binding factors, active vs passive transport across the cell membrane, post-AR mediated effects (glucocorticoid receptor antagonism). Just to mention a few.

Thanks for the time writing this up.

So to understand its the proportion or percentage of receptors occupied that creates anabolism? I can't wrap my head around why even though the same number of receptors are occupied and thus binding to DNA and causing the signaling pathways activation that the results would slow as more AR are presnt even though more aren't bound until dose goes up. Hopefully I worded this so you understand.
 
Thanks for the time writing this up.

So to understand its the proportion or percentage of receptors occupied that creates anabolism? I can't wrap my head around why even though the same number of receptors are occupied and thus binding to DNA and causing the signaling pathways activation that the results would slow as more AR are presnt even though more aren't bound until dose goes up. Hopefully I worded this so you understand.

You are asking questions that are beyond me, and even the ones that do know are probably operating on theory and conjecture to some extent. There are many steps between a hormone binding to receptor and transcription. It is fairly well known however that receptor up-regulation results in a lower sensitivity to a given amount of drug, this goes beyond just AAS and hormones.
 

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