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Preworkout tadalafil reduces cortisol response to training

johnjuanb1

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This study shows that tadalafil use before exercise reduces the cortisol response from exercise.

It is also known that tadalafil increases nitric oxide and gives one hell of a good pump.



The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise.

AuthorsDi Luigi L, et al. Show all Journal
Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E972-8. doi: 10.1152/ajpendo.00573.2011. Epub 2012 Feb 7.

Abstract

Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day with a 36-h interval) before a maximal exercise was performed. After a 2-wk washout, the volunteers were crossed over. Blood samples were collected at -30 and -15 min and immediately before exercise, immediately after, and during recovery (+15, +30, +60, and +90 min) for adrenocorticotropin (ACTH), β-endorphin, growth hormone (GH), prolactin, cortisol (C), corticosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol binding globulin (CBG) assays. C-to-CBG (free cortisol index, FCI) and DHEAS-to-C ratios were calculated. Exercise intensity, perceived exertion rate, O₂ consumption, and CO₂ and blood lactate concentration were evaluated. ACTH, GH, C, corticosterone, and CBG absolute concentrations and/or areas under the curve (AUC) increased after exercise after both placebo and tadalafil. Exercise increased DHEAS only after placebo. Compared with placebo, tadalafil administration reduced the ACTH, C, corticosterone, and FCI responses to exercise and was associated with higher β-endorphin AUC and DHEAS-to-C ratio during recovery, without influencing cardiorespiratory and performance parameters. Tadalafil reduced the activation of the hypothalamus-pituitary-adrenal axis during exercise by probably influencing the brain's nitric oxide- and cGMP-mediated pathways. Further studies are necessary to confirm our results and to identify the involved mechanisms, possible health risks, and potential clinical uses.
 
I notice I never get sore from training any more now that I take tadalafil preworkout. I was looking for studies today on whether or not tadalafil affected hgh release and this study came up which is incredibly cool IMO. Cortisol is evil!!!
 
Good find!!!

What sort of dosage are you using? 20mg EOD?

A friend of mine (a very smart guy who studied all this kind of thing for his university course/studies) used to tell everybody of the benefits of Viagra pre workout, and im going back around 10 years!!!

Stew
 
I notice I never get sore from training any more now that I take tadalafil preworkout. I was looking for studies today on whether or not tadalafil affected hgh release and this study came up which is incredibly cool IMO. Cortisol is evil!!!

Excellent find.
 
The lawyers are now suing saying that viagra causes skin cancer....wow...i know cialas and viagra are two different things but damn lawyers will link any successful drug like viagra that made Pfizer billions to line their shady pockets...
Study Links Melanoma to Viagra Use

tadalifil is used to treat PHA
Pulmonary Hypertension Treatment Tadalafil (Adcirca) - Pulmonary Hypertension Association

and for BPH
**broken link removed**

theres good and bad sides/treatment uses for every drug ever made...it's unfortunate - the ugly (lawyers) get involved.
 
yes...have always liked tadafil pre workout... just a lil bit, like like 5-10mg..any more and major head rush during heavy sets in my experience...
 
Too bad the shit fucks with my BP. Makes me drowsy.
 
Seems like such a waste to use it pre workout
 
Hmmm any reason not to make cheap generic tadalafil (Cipla brand) a part of our daily regimen...even for health? Or at least EOD due to its long half life. Only need 3 tabs a week (M-W-Sat, bc I have more sex Saturday and Sunday :)) Cipla brand is dirt cheap when you buy it bulk.

1. Lowers BP (approved for pulmonary arterial hypertension (PAH) as Adcirca®) Only suited for MILD BP elevation, IMO.
2. Reduces ACUTE PWO cortisol
3. Raging hard boners and improved sex
4. Improved pump and vascularity (NO/vaso)
5. Raging Hard boners...again.

Negative sides (for some, and what I have experienced)
1. Stuffy / congested nose feelings. Mostly only when I lay down a night.
2. Flushed face (especially if consuming even small amounts of alcohol)
3. Increased Heart burn (tren + cialis gave me the worst heartburn and I never get it)



What else am I missing? Any other negatives to using this stuff more often, if not even EOD?
 
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Seems like such a waste to use it pre workout

how much is a research bottle, like $20 for ~ 30ml at 30mg...? if 5-10mg a day only on training days was researched thats pretty cheap... have u tried it yet, its a noticeable difference IMO... plus you have a good dick day, everyday lmao
 
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how much is a research bottle, like $20 for ~ 30ml at 30mg...? if 5-10mg a day only on training days was researched thats pretty cheap... have u tried it yet, its a noticeable difference IMO... plus you have a good dick day, everyday lmao

Well I get that. I meant more along the lines of your body getting used to it. I've always felt it better to take only when necessary (sexual situations). Having to up the dose to get a boner kind of sucks.
 
Well I get that. I meant more along the lines of your body getting used to it. I've always felt it better to take only when necessary (sexual situations). Having to up the dose to get a boner kind of sucks.

yes, if i take it everyday the effects become lessened... i haven't noticed this to be the case w 4x a week tho... especially not at ~5mg... its literally like 3-4 drops out of the dropper... anytime I'm taking tadafil for sexual improvement its 20-30mg once and it lasts 2+ days..... I personally haven't noticed tolerance doing like this.. id be careful w the heart thing tho 4sure brotha, and 100% ask doc about it...
 
Only problem is I like to free ball it and pitching a tent the whole time I'm working out could be bothersome.

Maybe I shouldn't give a shit, give everybody at the gym a distraction..:headbang:
 
Hmmm any reason not to make cheap generic tadalafil (Cipla brand) a part of our daily regimen...even for health? Or at least EOD due to its long half life. Only need 3 tabs a week (M-W-Sat, bc I have more sex Saturday and Sunday :)) Cipla brand is dirt cheap when you buy it bulk.

1. Lowers BP (approved for pulmonary arterial hypertension (PAH) as Adcirca®) Only suited for MILD BP elevation, IMO.
2. Reduces ACUTE PWO cortisol
3. Raging hard boners and improved sex
4. Improved pump and vascularity (NO/vaso)
5. Raging Hard boners...again.

Negative sides (for some, and what I have experienced)
1. Stuffy / congested nose feelings. Mostly only when I lay down a night.
2. Flushed face (especially if consuming even small amounts of alcohol)
3. Increased Heart burn (tren + cialis gave me the worst heartburn and I never get it)



What else am I missing? Any other negatives to using this stuff more often, if not even EOD?

I think I remember reading somewhere it also had positive effects on the prostate. I will try to find it and post.
 
Good find!!!

What sort of dosage are you using? 20mg EOD?

A friend of mine (a very smart guy who studied all this kind of thing for his university course/studies) used to tell everybody of the benefits of Viagra pre workout, and im going back around 10 years!!!

Stew

I fill the pipette it comes with which is 1.5ml or 37.5mg
 
Hmmm any reason not to make cheap generic tadalafil (Cipla brand) a part of our daily regimen...even for health? Or at least EOD due to its long half life. Only need 3 tabs a week (M-W-Sat, bc I have more sex Saturday and Sunday :)) Cipla brand is dirt cheap when you buy it bulk.

1. Lowers BP (approved for pulmonary arterial hypertension (PAH) as Adcirca®) Only suited for MILD BP elevation, IMO.
2. Reduces ACUTE PWO cortisol
3. Raging hard boners and improved sex
4. Improved pump and vascularity (NO/vaso)
5. Raging Hard boners...again.

Negative sides (for some, and what I have experienced)
1. Stuffy / congested nose feelings. Mostly only when I lay down a night.
2. Flushed face (especially if consuming even small amounts of alcohol)
3. Increased Heart burn (tren + cialis gave me the worst heartburn and I never get it)



What else am I missing? Any other negatives to using this stuff more often, if not even EOD?

I never get a stuffy nose from tadalafil, only from Viagra.
 
Hmmm any reason not to make cheap generic tadalafil (Cipla brand) a part of our daily regimen...even for health? Or at least EOD due to its long half life. Only need 3 tabs a week (M-W-Sat, bc I have more sex Saturday and Sunday :)) Cipla brand is dirt cheap when you buy it bulk.

1. Lowers BP (approved for pulmonary arterial hypertension (PAH) as Adcirca®) Only suited for MILD BP elevation, IMO.
2. Reduces ACUTE PWO cortisol
3. Raging hard boners and improved sex
4. Improved pump and vascularity (NO/vaso)
5. Raging Hard boners...again.

Negative sides (for some, and what I have experienced)
1. Stuffy / congested nose feelings. Mostly only when I lay down a night.
2. Flushed face (especially if consuming even small amounts of alcohol)
3. Increased Heart burn (tren + cialis gave me the worst heartburn and I never get it)



What else am I missing? Any other negatives to using this stuff more often, if not even EOD?

Only negative I've seen is lower back aches on occasion from extended use. But maybe that was just from fkn so much while using it. lol
 
Well I get that. I meant more along the lines of your body getting used to it. I've always felt it better to take only when necessary (sexual situations). Having to up the dose to get a boner kind of sucks.

I think the key as already mentioned is low dose of 5-10mgs and not ED use, maybe M,W,F.
 
I think the key as already mentioned is low dose of 5-10mgs and not ED use, maybe M,W,F.

The Cipla tablets I have are 20mg which is the standard dosing for ED. I'm considering taking 3 a week, roughly EOD. Next stop Bonerville. Will report back on boners.

All jokes aside, I tend to agree though that chronic use will build a tolerance and over time the drug will possibly be less effective. Maybe it's best saved for the weekends?
 
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