DHEA and Pregnenolone -Swifto

[Swifto]

DHEA (The Mother of all Sex Hormones) and Pregnenolone (GrandMother of all Sex Hormones)


When the HPTA is shutdown, from the use of exogenous androgens, DHEA and Pregnenolone are also shutdown. So if your on cycle or on HRT/TRT, you should be replacing DHEA and Pregnenolone. Many petients on HRT are put on around 50mg/ED DHEA and around 25mg/ED Pregnenolone by their Endo's, exactly for this reason.

DHEA will improve immune function, insulin sensitivity, cognitive function and labido in males. So if you feel like any of the above are missing and your on cycle or HRT or in PCT, try supplementing 50mg/ED DHEA. It also needs to be split into 2 25mg doses due to its short half-life.

For the most effective way of using DHEA, it should be used as a transdermal cream/gel. But using it orally will work, but its not as effective, to my knowledge, as transdermal carriers. Within 2 weeks of oral DHEA administration, serum DHEA levels were restored in this study.

We use DHEA on cycle, during HRT or during PCT becuase,

"This is to help "back fill" the hormonal pathways disrupted by the secondary hypogonadism induced when we supplement testosterone." - Dr. Crisler (Swale)


So as you can see, supplementing both DHEA and Pregnenolone have MANY benifits. They should both be used on cycle, on HRT or during PCT IMHO. If your still not convinced, here are some more facts about DHEA and Preg:

- DHEA is also bioidentical (is natural). So, it will not reduce the bodies own DHEA levels. (Edit: I'm no longer so sure on this one. Thats why it should be used ONLY when endogenous DHEA levels are low)
- Supplemeting DHEA "off cycle" will not raise endogenous testosetrone in males.

- Using high amounts of DHEA on cycle, or on HRT will increase estrogen levels (estrone).

- DHEA is produced in the adrenal cortex of the brain and testes

- Most abundant steroid hormone

- The body converts cholesterol - pregnenolone - DHEA - androstenedione - testosetrone

- Low levels of DHEA have been linked to: Obesity (type II diabetes), immunne dysfunction, autoimmune disease, cancer, hypertension, cardiovascular disease, depression, loss of labido, erectile dysfunction and osteoporosis.


The following information has been compilled by my own research and correspondance with Dr. Crisler (Swale) who is an Endocrinologist.

For more information on DHEA, Pregnenolone, here (http://www.professionalmuscle.com/DheaPregMelatonin.ppt) is a powerpoint seminar Dr.Crisler gave on DHEA, Pregnenolone and Melatonin.

This is also very informative: DHEA

 

[Newman]

For the most effective way of using DHEA, it should be used as a transdermal cream/gel. But using it orally will work, but its not as effective, to my knowledge, as transdermal carriers. Within 2 weeks of oral DHEA administration, serum DHEA levels were restored in this study.

Good post Swifto.

I was told that although transdermal DHEA is absorbed far more effectively than oral administration, most of it is turned into testosterone by enzymes in human skin.

If true, this would seem to indicate that transdermal DHEA is best used as a test sup, while oral DHEA is best used to "backfill" the HPTA.

 

[Newman]

bump

 

[kbtoy]

What would be the benefit of supplementing these while on cycle? Since most of the benefits mentioned about DHEA you already get while on Test.

 

[Newman]

^^^^^^^^^^^^^^^^^^

Not sure who you're asking, but I'm thinking that since test is HPTA suppressive & since DHEA is a base hormone that many other hormones are made from, even just using test alone in a cycle MAY suppress DHEA production.

The point being that test isn't the only hormone our bodies need. Take oxytocin for example. If total or near total HPTA suppression results even from "test only" cycles, (forgetting cycles with highly suppressive stuff like Tren & Deca) then what else is suppressed besides test?

I have more questions than answers, but I gotta think that a recognised endo like Dr Swale probably doesn't go around advising DHEA while on cycle just to be different than other endos, or for DHEA company kickbacks...

(on the other hand, if you have proof that test only cycles will ONLY suppress natty test without affecting other hormones, like DHEA or oxytocin etc, then feel free to post up some links)