I started at 400 of primo per week...then dropped to 300....then 200. I got tested when I was taking 300. I would assume my lipids were worse at 400 and improved at 200, but I am not sure. Whatever the case, even if they improved at 200 the negative impact on my bloodwork was significant and the gains were minimal. I suspect (broscience here) that for most guys, Primo is maximized by using 750-1000 mg per week for 10-12 weeks and simply say f-it with the lipids and let them crash then work to get them back to the healthy range. But I am an older guy, so I cannot afford to be tanking HDL and Estro because those are heart protecting hormones and guys north of 40 are playing with fire if you allow those to crash.
I will say that if 400 gave me minimal gains, I am assuming 100 would give me nil. So, if there are no gains to be had, why introduce a substance that has a negative impact on the lipids at all? I would say if you are going to use it, go with an amount that at least gives you some tangible improvements to offset the negative impact on lipids.