Remember, the thread is about the synergy and interplay between 3 peptides. I didn't talk about GH and insulin dosing as much in the title post because we've beaten those horses to death over the years. IGF is just one of that trio of peptides GH/slin/IGF1. I highly doubt you'll find a higher level/ranked competing BBer out there that has never tried IGF-1. Could be, but I doubt it.
Consider how many times we've discussed various AAS effect on IGF-1 whether increasing or decreasing IGF-1 levels and how little we've discussed MGF modulation.
In any case, keeping in mind the extremely short half-life of exogenous IGF-1, we have a 30kg child (roughly 70lbs) taking approx 2mg up to twice a day as a starting dose. There are no dosage instructions for adults because it is only indicated for children 2-17yrs of age with growth abnormalities.
Also, higher IGF-1 concentrations are observed from even just dairy consumption and thus higher risk of cancer, mostly breast, prostate, and colon cancers in adults. This is a good factoid to remember when considering why IGF has never been (and likely never will) be approved for anything other than already prognosis negative adults (terminally diseased).
Increlex starting dose is 40 to 80mcg per kg in kids (say 40mcg per pound). But what a corresponding LR3 dose would be I have no idea really. So say 8800mcg of Increlex for a 220lbs bodybuilder. If it scales like that for bodybuilding, again I have no idea. That supposed Dallas McCarver cycle had 10-15mg of Increlex on training days. But the LR3 dosage did seem kind of arbitrary when it came out. I think the receptor grade LR3 was sold in 1mg vials IIRC (?) but that wasn't for use in humans, it was lab experiment material. Like I said, Palumbo said you couldn't use any more than 10mcg per day or you would immediately be desensitized, but I think he pulled that figure out of his ass lol.
I don't know if anyone tried 10 or more mg of LR3 per day... maybe it would be more effective, no idea. But then, I think it would be like GH in that it wouldn't immediately build a ton of muscle protein anyway, if the scale moved quickly it would be water.
It's an interesting thought experiment.
With a normal serum IGF-1 range of 90-360ng/mL in a 200lb adult between the ages of 20-30yrs we can weakly extrapolate assuming 6,000 ml of blood in a 200lb adult (6 liters) and at 360ng/mL high end (0.36mcg/mL) will put us at approx 2mg of total serum IGF-1 at any given time in a 200lb adult aged 20-30yrs (which wouldn't include that found in tissues).
This would infer that it would take 2-4mg IV (not IM or subQ) to merely double serum IGF-1 levels.
I've had my GH levels tested but never IGF. So maybe someone who has had theirs tested could weigh in here with a number they saw through blood testing.
edit: consider also that we originally tested the quality of rhGH samples through bloodwork by testing IGF levels rather than serum GH levels so GH and IGF are obviously seen as closely related
The present study establishes age- and sex-specific reference values for a fully automated immunoassay system based on a large population of healthy subjects. The established reference values may be used for this immunoassay system in different laboratories provided that the systematic...
pubmed.ncbi.nlm.nih.gov