- Joined
- Oct 7, 2022
- Messages
- 228
Some drug therapies
for obesity don't work
very well. Scientists are
examining other chemicals
in the body to determine
which ones can serve as
the basis for an effective
weight-loss drug without
significant side effects.
Three candidates include
cholecystokinin, ghrelin
and PYY. Cholecystokinin
is released in the upper gut
in response to breakdown
products of digestion. It
decreases appetite. Ghrelin
stimulates appetite and
levels are particularly
high immediately before
a meal. Carbohydrates
depress ghrelin more than
fats. PYY, another gut
hormone, suppresses the
desire for food intake for
extended periods and may
be an excellent candidate
for a weight-loss drug.
Harnessing appetite control
hormones may be a safe,
effective way to fight fat.
(Nutrition Today, 40: 112-115)
for obesity don't work
very well. Scientists are
examining other chemicals
in the body to determine
which ones can serve as
the basis for an effective
weight-loss drug without
significant side effects.
Three candidates include
cholecystokinin, ghrelin
and PYY. Cholecystokinin
is released in the upper gut
in response to breakdown
products of digestion. It
decreases appetite. Ghrelin
stimulates appetite and
levels are particularly
high immediately before
a meal. Carbohydrates
depress ghrelin more than
fats. PYY, another gut
hormone, suppresses the
desire for food intake for
extended periods and may
be an excellent candidate
for a weight-loss drug.
Harnessing appetite control
hormones may be a safe,
effective way to fight fat.
(Nutrition Today, 40: 112-115)