I’ve tried both Sema and Tirz. Tirz all day everyday IMO. Sema gave me and the wife terrible gastro sides (bloating, constipation, nausea) and we never made it over 0.5mg a week. I will say that both absolutely do exactly as intended but Tirz seems like a background drug quietly working. The only thing I got from Tirz was random constipation which was always contributed to a lack of consistent water consumption. Quickly remedied by hydration and some form of natural food based bump in Fiber.
Both IMO are going to cause fatigue just due to the fact that your calories become significantly reduced. It’s actually rather mind blowing how they work at such a low dose. 2.5 mg a week of Tirz will seem like nothing is happening until you realize your portions are getting smaller and smaller by the day and look in the mirror about 3 or 4 weeks later.