- Joined
- Sep 17, 2009
- Messages
- 1,140
I'm going to start taking telmisartan again for a number of reasons. It is seriously one of the most overlooked fat loss body comp aids out there. It's a long term solution to metabolic syndrome, something that can't be said about almost any other fat loss drug out there except for DNP, but micardis is safer.
But one of the new reasons I'm re-ordering it is due to this study I was just reading
**broken link removed**
Puffy hands? High blood pressure? Aldosterone is probably at the root of this.
So is there any medicine out there good at inhibiting this?
Yes there is **broken link removed**
So I'll be going back on 80mg a day. Honestly I stopped because it was making me dehydrated. But this time around GH is causing too much sodium to be retained, so I'm going to find a dose that will balance this whole thing out.
It may also make it possible for me to experiment with the higher doses that others can take and get away with.
I have a feeling those who don't get the puffiness and high bp issues from GH also happen to naturally express less angiotensin 2.
But one of the new reasons I'm re-ordering it is due to this study I was just reading
**broken link removed**
In summary, we show that chronic GH excess is associated with increased aldosterone in humans and mice. GH-induced increases of aldosterone potentially contribute to the increased cardiovascular risk in acromegalic patients. The underlying mechanism is likely to be independent of renin, excess IGF-I, or adrenal aldosterone synthase expression.
Puffy hands? High blood pressure? Aldosterone is probably at the root of this.
So is there any medicine out there good at inhibiting this?
Yes there is **broken link removed**
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.
So I'll be going back on 80mg a day. Honestly I stopped because it was making me dehydrated. But this time around GH is causing too much sodium to be retained, so I'm going to find a dose that will balance this whole thing out.
It may also make it possible for me to experiment with the higher doses that others can take and get away with.
I have a feeling those who don't get the puffiness and high bp issues from GH also happen to naturally express less angiotensin 2.