Trigonelline….?

[whacked]

Anyone hear of this stuff?

Was researching some things related to NAD.

Trigonelline is an alkaloid compound obtained from fenugreek and is clinically employed in management of diabetes and some central nervous system disorders. It has some pretty interesting attributes along with life span extension, reduces homocysteine, boosts memory, amongst others.

1. https://pubmed.ncbi.nlm.nih.gov/226...,auditory neuropathy and platelet aggregation.

Trigonelline has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and it has been shown to reduce diabetic auditory neuropathy and platelet aggregation.

It acts by affecting β cell regeneration, insulin secretion, activities of enzymes related to glucose metabolism, reactive oxygen species, axonal extension, and neuron excitability

2. https://www.nature.com/articles/s41598-020-73514-1

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule​

 

[micro2000]

Interesting. Most plant compounds have horrible bioavailability but trigonelline seems to have decent bioavailability in humans.

 

[okko]

Risk Assessment of Trigonelline in Coffee and Coffee By-Products

Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations in coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves, flowers, cherry husks or pulp, parchment, silver skin, and spent grounds. In the past, coffee by-products were...

www.mdpi.com

 

[nothuman]

Yea I actually just heard of it for the first time about a week ago.

Thankfully, coffee has a lot of Trigonelliline