Here we go.. There are 3 parts to this article, and this quote is out of the 2nd, which can be found here -
Traditional Growth Hormone and the Rise of GH Peptides ? Part 2
"In terms of achieving peak GH levels, Hexarelin is the most potent of the bunch. When paired with the GHRH known as ModGRF1-29, a synergistic effect takes place, further amplifying the resultant GH spike. In order to appreciate Hex’s true potency let’s compare it against a less powerful, although still quite strong GH peptide combination in the form of GHRP-2 & ModGRF1-29. In Part #1 of this article we looked at a graph comparing the GH elevating properties of this combo to that of 7.5 IU of exo GH. Surprisingly, the peak GH level achieved with the peptides was roughly 2X higher than the reading obtained with the exo GH; similar to what would have been witnessed with a 15 IU inject.
When Hexarelin is substituted for GHRP-2 at optimal dosages, the results are even more stunning, with peak GH levels rivaling a 20IU injection of exo GH and in some cases surpassing it. In order of potency, Hexarelin is trailed by GHRP-2, GHRP-6, and finally Ipamorelin, but even though Hex is the most potent in its class, don’t be fooled into thinking that it is the only GHRP worth using. The unique characteristics associated with each of the GHRP’s, their different pharmacodynamic profiles, and diversity in user goals all play a role in constructing the ideal GH peptide program.
If the primary goal is maximizing GH release, including this powerful peptide in your program makes sense, but what is the best way to go about it? The following facts will help point you in the right direction:
The synergistic effect noted with Hexarelin and ModGRF1-29 is lost after repeated administration, resulting in a reduced GH response after just a single injection.
Hexarelin interferes with slow wave sleep; the stage of sleep responsible for cerebral restoration and physical recovery
Hexarelin results in desensitization with twice daily dosing. In one particular study, GH output decreased by roughly 35% after just a single week of treatment and a full 50% decrease was apparent at week 16. 4 weeks post-treatment, sensitivity was fully restored.
Hexarelin results in an increase in prolactin and cortisol when used at doses of 100 mcg/kg and above.
When Hexarelin is dosed at .25 mcg/kg and .50 mcg/kg, the prolactin & cortisol increasing effect is abolished.
When ModGRF1-29, at a dose of 100 mcg, is combined with lower-dose Hexarelin (.25 mcg/kg and .50 mcg/kg), GH levels were increased beyond those achieved with Hexarelin alone at both 100 mcg/kg and 200 mcg/kg, demonstrating an extreme synergistic effect and an ability to increase GH to near maximal levels without an accompanying increase in prolactin or cortisol.
Hexarelin has no affect on appetite.
Hexarelin and GHRP-2 increase prolactin & cortisol similarly.
Taking into consideration the above factors, we can draw some definite conclusions. For one, Hexarelin is probably not best used right before bed. The degree to which Hexarelin negatively impacts slow wave sleep is not fully understood, but even if the negative effects only extend to a single sleep cycle, we are still better off using another GHRP at this time.
Another factor that will dramatically affect how we how we implement Hex into our program is the loss of synergism that occurs between Hex and ModGRF1-29 after repeated administration, as well as the desensitization experienced with extended use. According to clinical research, when Hex is administered just 2X daily, GH output is diminished by 35% after just one week of use. Although this is significant, the good news is that despite this reduction, GH output remains relatively high and stable for the following 4 weeks.
In my opinion, the best way to deal with these flaws is to alternate Hexarelin with a GHRP that lacks this desensitizing effect. For example, by continuing to administer Hex twice daily, but only 3-4 days per week (with GHRP-2 taking up the slack on the other days), one is able to avoid the rapid desensitization that occurs with daily use, while still taking advantage of Hex’s superior GH releasing benefits.
When it comes to the loss of synergism between Hex and ModGRF1-29, a simple fix may not be so easy to find due to a lack of information on the subject. At this juncture, no research has been conducted with the purpose of examining the relationship between dosing intervals and maintaining synergy. The study responsible for demonstrating the loss of synergy with repeated administration limited dosing intervals to a maximum of 120 minutes—hardly sensible. Assuming this research was aimed at increasing our knowledge of potential human application and with the typical person’s waking day lasting about 16 hours, it would have made much more sense to expand the dosing intervals to at least 12 hours.
Unfortunately, the best we can do is speculate when attempting to determine which dosing intervals are required for maintaining synergy, while using anecdotal evidence as a guide. Based on user bloodwork, synergy remains unaffected when using Hex once daily on a 3-4X weekly dosing schedule. However, with such a short half-life, dosing Hex only 3-4X weekly is far from optimal. The good news is that even if synergy is lost, the Hex & ModGRF1-29 combo still provides greater GH elevating effects than the 2nd most potent GH releasing combo; GHRP-2 & modGRF1-29. Therefore, a loss of synergism, although undesirable, really isn’t the main issue—desensitization is. Regardless, it is still wise to try and maximize this synergistic effect."
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