bad ankle edema from DNP?

[buzzbomb138]

ive been PSMFing on 400mg powder DNP (along with 500 test/tren each, EC, GH, inj l-carn) for the last 11 days and just got back from walking on the incline at the gym and holy shit when i went to put new socks on after showering my ankles have completely disappeared. ive run DNP many times in the past but usually 200-300mg for a few wks and never have noticed this at all. i have been a lil short of breath since starting but chalked that up to the DNP as it always makes me feel winded even just talking lol, plus tren doesnt help in the breathing dept either.

im down 10 lbs since starting but i do look pretty watery which i know the DNP causes but holy shit i havent ever held this much water from this shit before ever and its kinda scaring me. i have one last cap of it tomorrow ill finish off but god damn idk if ill run this shit again seeing as how one of DNP's positives is supposedly no CV stress but if it makes u hold that much water like a heart failure patient then maybe its not lol.

 

[Cabron]

pic?

 

[buzzbomb138]

pic?

ill send u my OF link lol

 

[Wonton]

ive been PSMFing on 400mg powder DNP (along with 500 test/tren each, EC, GH, inj l-carn) for the last 11 days and just got back from walking on the incline at the gym and holy shit when i went to put new socks on after showering my ankles have completely disappeared. ive run DNP many times in the past but usually 200-300mg for a few wks and never have noticed this at all. i have been a lil short of breath since starting but chalked that up to the DNP as it always makes me feel winded even just talking lol, plus tren doesnt help in the breathing dept either.

im down 10 lbs since starting but i do look pretty watery which i know the DNP causes but holy shit i havent ever held this much water from this shit before ever and its kinda scaring me. i have one last cap of it tomorrow ill finish off but god damn idk if ill run this shit again seeing as how one of DNP's positives is supposedly no CV stress but if it makes u hold that much water like a heart failure patient then maybe its not lol.

I always relate ankle swelling to kidney issues

Right or wrong , air on caution

 

[juggy38]

Oh heart failure.

 

[Ruhlfreak55]

I didn't really get the holding water side effect at all taking it at the beginning of the year here. I'm also just doing 250 with 500 the last couple days though.

 

[buzzbomb138]

I always relate ankle swelling to kidney issues

Right or wrong , air on caution

interesting, i always thought it was a sign of heart failure. ill look into that more.

Oh heart failure.

lol thats what im sayin bro! lol

I didn't really get the holding water side effect at all taking it at the beginning of the year here. I'm also just doing 250 with 500 the last couple days though.

ya me niether, but ive never ran it at this dose for this length of time before so idk what to think. i just took my last cap so itll start clearing my system here soon so ill have a better idea if thats what it is or not soon. the only other thing im on that could be bloating me is 500 test e but thats a medium dose and never done that too me before. plus im using some adex to keep e2 in check as well.

 

[Elvia1023]

It could be due to so many things. You are taking 500mg test and tren (kidneys) for example. Yes DNP can make you hold water but so can HGH. How much HGH are you on and what brand? If it's as bad as you state I would suggest lowering you doses of everything.

 

[heavyhitter]

If I did nothing differently except add dnp and started having ankle swelling, I’d be looking into possible renal impairment

 

[TrippplePPP]

Whats your blood pressure?

 

[buzzbomb138]

It could be due to so many things. You are taking 500mg test and tren (kidneys) for example. Yes DNP can make you hold water but so can HGH. How much HGH are you on and what brand? If it's as bad as you state I would suggest lowering you doses of everything.

3.5 ius TP's blacktops, same as ive been on for like 8 mths now

If I did nothing differently except add dnp and started having ankle swelling, I’d be looking into possible renal impairment

u mind elaborating? ur the second person to mention edema and the kidneys and its always been my understanding that edema was more heart failure related. my BP off cycle is always awesome (110/65) and this is my first cycle in 2 yrs so idk how my kidneys couldve gotten so fucked in the 2 wks ive been on this cycle lol.

Whats your blood pressure?

its been elevated at 130-150/75-85 depending on when i take it (like if the EC is in my system), but not horribly so. thats usually where it runs for me on cycle. off cycle on just TRT/GH im 110/65 so never worried about BP off cycle really. i started 40mg telmisartan a few days ago and will bump it to 80mg tonight. btw just took it and its 131/65 at 1030pm a few hrs after cardio (going for a long walk).


anyways, i finished my last DNP cap earlier today so itll be clearing my system over the next few days so hopefully it improves. if its not better by the wkend, ill go get it looked at. also i had a dr appt today and the dr listened to my breathing thru the stethoscope and didnt say anything about hearing fluid in my lungs and i know thats one symptom of having heart failure so i guess thats good lol.

 

[heavyhitter]

3.5 ius TP's blacktops, same as ive been on for like 8 mths now

u mind elaborating? ur the second person to mention edema and the kidneys and its always been my understanding that edema was more heart failure related. my BP off cycle is always awesome (110/65) and this is my first cycle in 2 yrs so idk how my kidneys couldve gotten so fucked in the 2 wks ive been on this cycle lol.

its been elevated at 130-150/75-85 depending on when i take it (like if the EC is in my system), but not horribly so. thats usually where it runs for me on cycle. off cycle on just TRT/GH im 110/65 so never worried about BP off cycle really. i started 40mg telmisartan a few days ago and will bump it to 80mg tonight. btw just took it and its 131/65 at 1030pm a few hrs after cardio (going for a long walk).


anyways, i finished my last DNP cap earlier today so itll be clearing my system over the next few days so hopefully it improves. if its not better by the wkend, ill go get it looked at. also i had a dr appt today and the dr listened to my breathing thru the stethoscope and didnt say anything about hearing fluid in my lungs and i know thats one symptom of having heart failure so i guess thats good lol.

Well here’s just a little part of it
Edema forms in patients with kidney disease for two reasons:
1. A heavy loss of protein in the urine
2. Impaired kidney (renal) function
In this situation, the patients have normal or fairly normal kidney function. The heavy loss of protein in the urine with its accompanying edema is termed the nephrotic syndrome. Nephrotic syndrome results in a reduction in the concentration of albumin in the blood (hypoalbuminemia). Since albumin helps to maintain blood volume in the blood vessels, a reduction of fluid in the blood vessels occurs. The kidneys then register that there is depletion of blood volume and, therefore, attempt to retain salt. Consequently, fluid moves into the interstitial spaces, thereby causing pitting edema.
Podocytes are essential for normal functioning of glomerular filtration barrier (GFB) of the kidney. Damage or loss of podocytes causes glomerulosclerosis nephrotic syndrome in humans. In fact, disruption of the GFB is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.

Edema and acute renal failure - PubMed

Acute renal failure (ARF) with overhydration and edematous state may follow Acute endocapillary proliferative glomerulonephritis and extracapillary glomerulonephritis, because of reduction of the glomerular capillary area available for filtration. But ARF may also be observed in edematous...

pubmed.ncbi.nlm.nih.gov

And I wouldn’t rule out cardiac issues with something like DNP

 

[heavyhitter]

Furthermore, dinitrophenol treatment increased urinary protein excretion, kidney vimentin expression and infiltration of inflammatory cells. In conclusion, increased mitochondrial oxygen consumption results in kidney hypoxia and subsequent nephropathy.

 

[buzzbomb138]

Well here’s just a little part of it
Edema forms in patients with kidney disease for two reasons:
1. A heavy loss of protein in the urine
2. Impaired kidney (renal) function
In this situation, the patients have normal or fairly normal kidney function. The heavy loss of protein in the urine with its accompanying edema is termed the nephrotic syndrome. Nephrotic syndrome results in a reduction in the concentration of albumin in the blood (hypoalbuminemia). Since albumin helps to maintain blood volume in the blood vessels, a reduction of fluid in the blood vessels occurs. The kidneys then register that there is depletion of blood volume and, therefore, attempt to retain salt. Consequently, fluid moves into the interstitial spaces, thereby causing pitting edema.
Podocytes are essential for normal functioning of glomerular filtration barrier (GFB) of the kidney. Damage or loss of podocytes causes glomerulosclerosis nephrotic syndrome in humans. In fact, disruption of the GFB is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.

Edema and acute renal failure - PubMed

Acute renal failure (ARF) with overhydration and edematous state may follow Acute endocapillary proliferative glomerulonephritis and extracapillary glomerulonephritis, because of reduction of the glomerular capillary area available for filtration. But ARF may also be observed in edematous...

pubmed.ncbi.nlm.nih.gov

And I wouldn’t rule out cardiac issues with something like DNP

Furthermore, dinitrophenol treatment increased urinary protein excretion, kidney vimentin expression and infiltration of inflammatory cells. In conclusion, increased mitochondrial oxygen consumption results in kidney hypoxia and subsequent nephropathy.

cool, appreciate the info. im not having any overly foamy pee and im peeing just fine so i dont think its protein in my urine or other kidney issues. ill keep an eye out tho and if things dont improve over the next few days, ill def get checked out.

 

[heavyhitter]

cool, appreciate the info. im not having any overly foamy pee and im peeing just fine so i dont think its protein in my urine or other kidney issues. ill keep an eye out tho and if things dont improve over the next few days, ill def get checked out.

In the short term, try increasing sodium by 1-2 grams daily, and make sure to take in adequate potassium. Peppers, spinach, and potatoes if any kind contain lots. Ultimately, the issue is likely dnp screwing with your electrolyte balance

 

[buzzbomb138]

In the short term, try increasing sodium by 1-2 grams daily, and make sure to take in adequate potassium. Peppers, spinach, and potatoes if any kind contain lots. Ultimately, the issue is likely dnp screwing with your electrolyte balance

this exact thought had crossed my mind too. since im PSMFing my diet hasnt been varied at all. i get plenty of magnesium thru my creatine (its a magnesium bonded-creatine) and have been having lots of whey/casein shakes and a lil bit of greek yogurt so i think im still getting a decent amount of potassium and calcium, but my sodium intake may be low. im gonna add some high sodium hot sauces to my meats today and see how that goes.

 

[heavyhitter]

this exact thought had crossed my mind too. since im PSMFing my diet hasnt been varied at all. i get plenty of magnesium thru my creatine (its a magnesium bonded-creatine) and have been having lots of whey/casein shakes and a lil bit of greek yogurt so i think im still getting a decent amount of potassium and calcium, but my sodium intake may be low. im gonna add some high sodium hot sauces to my meats today and see how that goes.

Eat a couple pickles a day. Tastes good and easy to get in sodium and potassium

 

[buzzbomb138]

Eat a couple pickles a day. Tastes good and easy to get in sodium and potassium

dude thats a great idea, awesome tip. and theyre zero cals so great for dieting snack.


so its been 36 hrs since last DNP dose and the ankle edema seems to have noticeably receded. my BP is down today as well but could be because i bumped telmisartan from 40mg to 80mg last night. just got back from training legs and the shortness of breath i was having has def lessened as well, and i dont notice it at all when doing cardio but the only cardio ive been doing lately is long walks outside or on the incline.

ill update this thread again tomorrow or the next day

 

[Nike22]

dude thats a great idea, awesome tip. and theyre zero cals so great for dieting snack.


so its been 36 hrs since last DNP dose and the ankle edema seems to have noticeably receded. my BP is down today as well but could be because i bumped telmisartan from 40mg to 80mg last night. just got back from training legs and the shortness of breath i was having has def lessened as well, and i dont notice it at all when doing cardio but the only cardio ive been doing lately is long walks outside or on the incline.

ill update this thread again tomorrow or the next day

Glad to hear the good news.

Were you running crystal or powder DNP? Going from200-300 to 400 with powder is definitely a bigger step than with crystal. I've run both a number of times and 400-450 powder made me hold water pretty bad but 600mg crystal not so much, might just be my body chemistry but that's my 2 cents.

 

[Elvia1023]

3.5 ius TP's blacktops, same as ive been on for like 8 mths now

By this and your other posts it's obviously the DNP. By your wording I thought you had started everything together so that's why I figured HGH would be the most obvious but it could have been any or a combination of things. DNP can definitely make people hold water though but it's not usually overly bad for most if they keep an eye on calories and electrolytes. I remember trying 1iu riptropin back in the day and put on 10 pounds of water in a few days. I have used blacktops recently and when I come off I usually drop a few pounds in a few days. If you ever use it again you are probably best sticking to approx 200mg per day. There is definitely a big difference moving from 200mg to 400mg. You mention your bp is usually fairly low off cycle so be careful with 80mg telmisartan and perhaps lower it back to 40mg in the near future or stop it completely if your bp goes low again.