Honestly, this has been going on so long it's tough to tell all of it. Achy joints (knees especially) are the biggest sign. Oddly, I also experience some edema and water retention fairly easily. I'm assuming through other pathways than E2. Mentally, I'm unsure anymore how it affects me. Maybe just my new norm.Are you experiencing side effects from having your E2 so low?
I also just tested my IGF1 serum levels since I've used HGH for several months and wanted to gauge that effectiveness. IGF1 level was exceptionally low at 42. From what I've read, this could be a sign of low E2.