I think as long as you don't abuse it you should be OK and it'd probably be more psychological than physiological. It definitely gives you more confidence.
Only advice I'd give is try to get trimix and not just PGE. I used PGE for years and if you dose wrong it'll feel like your dong got run over by a steam roller. I don't have the same issues with trimix. Also PGE can be hard to find at times so I was constantly looking for a source, finally broke down and got a script for it online and it was super easy and not that much more than buying PGE from a UGL, plus you get antidote, syringes and alcohol wipes with the purchase. They'll also custom blend your mix for you.
Start on the low side of dosage as over dosing can be pretty painful so know the possible antidotes.