Mesterolone (Proviron) works great in the presence of E.
When E is present, it will chase it out of the DHT receptor (Thats its intended medical function) giving you the benefit of an activated DHT receptor and simultanious presence of E.
remember you need all 3 Test, E and a little DHT to be happily hormonaly balanced.
That being said, it WILL have adverse reactions when the E is low to start with. That is because it will competitively bind to the E receptor as it has better affinity there. Again, that is its intended medical use (Think E dependent tumors).
I can get into its effect on SHBG a latter if you folks are interested.
Please do expound further on mesterolone's effect on SHBG. In particular, how the effects would differ between guys with low SHBG or guys like myself with high SHBG.
I am 50 and have been taking test and other steroids for 26 years now. Especially when I was younger, DHT-based compounds like Masteron and Proviron would have a great effect on my libido and sense of well-being. Masteron was always my favorite steroid (along with test, of course.)
But now that I am older my interests have shifted more towards TRT and fertility, as my wife and I are trying to have another child.
Since November I have been taking 25mg of Proviron a day as part of my fertility program, which has changed over the months but has boiled down to the following:
200mg test per week
500iu HCG every other day
60iu HMG every day
50mg Clomid every day
25mg Proviron every day
2-4iu HGH every day
This program seems to have been successful. My wife and I had IVF done this week. They extracted 21 eggs from her, of which my sperm fertilized 14. So hopefully I will be a father again soon.
However, I am always interested if the program could have been better or worse, for other people who want to try a fertility program in the future.
Regarding Proviron, I started out with good free test numbers (21.0 on a range from 7.2-24.0 pg/mL, total test at 1014 ng/dL), but as the program went on my SHBG rose to very high levels (112.5 on a range from 19.3-76.4 nmol/L).
This obviously had a negative effect on my levels of free test and free E2, both of which are important to libido and erectile function. And my libido was good at first but much worse as the program went on, although obviously it is hard to separate out the combined effects of all the compounds involved (HCG, HMG, Proviron, Clomid, the letrozole my fertility doc had me on for a while before it drove E2 too low, etc.)
I will start a separate thread on the fertility program, as I know it would benefit other men in the same position in the future.
But I am very interested toward your thoughts on Proviron and it's effect on SHBG, and it's differing effects on men with low SHBG vs high SHBG.