Link is full Text
https://www.sciencedirect.com/science/article/pii/S2666379123005402
I did feel that this was warranted to be a stand-alone post simply because this is new, and a rather novel finding disproving the long-held belief that there are caps on maximizing MPS, and could generate some good discussion. Mods, please remove if you feel this is more appropriate as a comment elsewhere.
Abstract Summary
The belief that the anabolic response to feeding during postexercise recovery is transient and has an upper limit and that excess amino acids are being oxidized lacks scientific proof. Using a comprehensive quadruple isotope
tracer feeding-infusion approach, we show that the
ingestion of 100
g protein results in a greater and more prolonged (>12 h) anabolic response when compared to the ingestion of 25 g protein. We demonstrate a dose-response increase in dietary-protein-derived plasma amino acid availability and subsequent incorporation into muscle protein. Ingestion of a large bolus of protein further increases whole-body protein net balance, mixed-muscle, myofibrillar, muscle connective, and plasma
protein synthesis rates. Protein ingestion has a negligible impact on whole-body
protein breakdown rates or amino acid oxidation rates. These findings demonstrate that the magnitude and duration of the anabolic response to protein ingestion is not restricted and has previously been underestimated
in vivo in humans.