Anecdotally the evidence is easily strong enough that this works in my personal opinion. I don’t doubt cyclodextrin would help though. But because the effect of the drugs is so easily recognizable, and we all know what they feel like, and the fact that the drugs in their pure form are taken in the 20-100+ mg range, and they fully disappear with no swallowing at all, and dissolve fully relatively quickly, this says to me that there is some way they’re dissolving. 100mg of raw would be something you’d notice if it wasn’t disappearing. Where is it going if not swallowed ?
Like to anyone reading- just try it.
You’ll get the effect within 20 minutes with no swallowing if done correctly.
One possible mechanism is that cell membranes themself are lipophilic.
So I think the actual saliva concept is misleading us from the point that two facts required for absorption are present here. A lipid soluble drug, and a cell membrane that brings in lipid soluble molecules due to the cell membrane itself being nonpolar.
They don’t need saliva to dissolve into if the actual drug molecule makes contact with the actual cells under the tongue. Which is actually easier to accomplish than you’d think when dump powder onto a fully dry tongue then lay the tongue down over that powder. Some saliva may get in that space and interrupt absorption making it slightly slower. But it’s possible to do almost completely dry and spread an even layer of the drug over the surface under the tongue without saliva.
this post post actually made me laugh out loud.
friend, you do understand that "feel" in this case is purely your imagination, yes?