MECHANISM OF ACTION
Nivalin binds electrostatically to the enzyme active site of cholinesterase. Binding is reversible; thus, it acts as a competitive reversible inhibitor of cholinesterase and prolongs the hydrolysis of endogenous acetylcholine, thereby increasing its accumulation and prolonging and potentiating its effects, which are expressed in intensified and prolonged mediation at the level of cholinergic postsynaptic membrane. Nivalin has been found to exert direct effect on some CNS structures with cholinergic neurons. It also acts in CNS by reflex pathway, potentiating afferent impulses from some peripheral reflexogenic areas,
Effect of Nivalin on neuromuscular transmission
Nivalin prolongs the action of acetylcholine on postsynaptic membranes and its accumulation in the synaptic gap, thereby increasing the intensity and duration of nerve impulse transmission to muscle tissues. The strength and duration of muscle contraction increases.
(Acetylcholine has functions both in the peripheral nervous system (PNS) and in the central nervous system (CNS) as a neuromodulator. In the peripheral nervous system, acetylcholardiac muscle fibers activates muscles and is a major neurotransmitter in the autonomic nervous system. In the central nervous system, acetylcholine and its associated neurons form the cholinergic system).