As a decade plus user of aromasin, with a ton of blood work over those years, maybe someone finds this useful.
Back in "the day" we had Nolvadex and that was it. I started trt around 2010ish which brought me back around some. Started with the aforementioned 200mg weekly, hcg, etc and 1mg of arimidex a few times a week and promptly cashed my E2 (elbow pain is a first sign for me). After having them blow me up a few times, I moved to aromasin and it was smooth sailing.
For me - I've never seen any variability on lipids with aromasin (tren and orals... sure). E2 has always been rock stable and predictable. I don't time my intake nor combine it with specific foods and often will take 12.5mg on a Monday/Thursday (will go M/W/F or more frequently as I need more, finally upping the daily dosage). Means nothing evidenced by tons of bloods. Very predictable. Only time I've crashed E2 is when I've loaded up a big masteron or equipoise dose (equipoise is the hardest E2 hit even vs primo and mast as I've recently learned and hits E2 a lot faster than the ester math would indicate or results in the gym become noticeable - ouch). My aromatization hasn't changed that I've seen.
All that said, it's my own independent experience and generally test is 750-500mg maybe 1gram max with total compounds under 2 or 2.5grams if running lighter stuff (ie light being primo or equipoise or masteron in there increasing total my NOT tren in a big dose). If I was running much bigger test, maybe some of this wouldn't hold. Also my AI is always pharma as is my Nolvadex or anything else I might really need if an issue shows up. Never has but all the 60s and 70s pros had the same experience and then one day the estradiol in them won out and bitch tit surgery became common so I'll take a light AI dose over letting E2 run rampant at sky high levels all the time.