DO NOT BUY/USE GW-501516

[RamboStallone]

What kind of solution? I tried 30mg/ml in grain alcohol and it's pretty chunky

PEG300, 20mg not 30mg brother.

 

[Bull_Nuts]

I use it extensively...especially with tren...so far...no cancer...my wife has stage 4 carcinoid cancer. She hasnt touched it. Maybe it only causes cancer on the loved ones of the users.

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[allornothing]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519722/#!po=26.6234

Promotes liver fibrosis???

 

[IsaacHaze1]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519722/#!po=26.6234

Promotes liver fibrosis???

you read the whole study right....

after liver injury

 

[Mike Arnold]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519722/#!po=26.6234

Promotes liver fibrosis???

There are also other studies showing it heals the liver.

 

[broheim]

I hope none of you have been stupid enough to feed your research animals this stuff...



Source: Anti-doping agency warns athletes of black market drug - health - 26 March 2013 - New Scientist

In the research study it states that the the mice were dosed with something like 400 times the effective dose for a period of months on end without a break. Also not all the mice got ill, some were actually still healthy.

The endurance, fat burning and nutrient partitioning effects are undeniable for me. I have cycled a few times always with very noticeable result within days. Also knock lethargy while on cycle right in the dirt. Not to mention faster recovery times and less DOMS. Professional Olympic cyclists, and endurance athletes have been using it for years to enhance performance with no negative results reported to date.

Is there anyone that has reported any side effect or tumors as a result of cardarine usage?

 

[broheim]

Here is a write-up that I found tying some studies together. The extreme doses used in the studies would be equivalent to 660mg per day for a 220lb man. The current effective dose ranges from 1-50mg per day. That is a huge contrast. Anything would kill you at that dosage.

https://en.wikipedia.org/wiki/GW501516
https://www.evolutionary.org/gw-501516-cardarine-cancer

SARMS
N. Matty
GW-501516 (Cardarine) and Cancer


1 Arguments for Cancer
1.1 Rodent Studies
1.2 Flawed Testing Methods
1.3 Scientific Basis for the Link to Cancer
2 Arguments Against Cancer
1.1 Scientific Basis Against Link to Cancer
1.2 Studies
3 Research Material


Arguments for Cancer

Rodent Studies

In just about every thread you can find about the use of GW-501516 (GW or Cardarine) in humans, somebody always feels the need say it causes cancer. This is mainly based on a study in which rodents who were subjected to GW developed cancer during the clinical trials, which is partially true. Though, the information these people tend to leave out is under what conditions were these rodents developed cancer during the study. This argument is either because they are repeating something they read online, or realized if they cited the actually study their argument would lose all validity. The study, that is so often referred to, subjected rats to supraphysiological dosages of 10mg/kg of body, or to put that in perspective, a 200lb man (roughly 90 kg) dosing around 900mgs of GW-501516 per day. These doses defy any sensible logic and, therefore, hold no standing at the suggested dosage of 20mg a day.

The study cited above, rats were given the equivalent of a 900mgs dose of GW; this would be comparable to taking 14,625 mgs of aspirin per day. Usually, 325 mgs of aspirin is 1 dose (1 pill). This dose of aspirin could literally KILL you, forget cancer!
gw-501516 chemicalstructure

Fig 1. GW-501516 Chemical Structure

Flawed Testing Methods

Certain studies supporting the claim that GW causes cell proliferation in human cancer cell lines were flawed from the very beginning. These studies set out to prove an increase growth of cancer cells by estimating the number of cells using a method that tested for enzyme activity, increased activity would indicate more cells. The issue with this testing method is the very substance that they are testing with actually increases enzyme activity within cells. One can quickly see that judging cell proliferation by enzyme activity, while introducing a substance that increases enzyme activity, can give skewed results in regards to an increase in cells. Even if no increase in cells occurred, the increased enzyme activity could lead one to believe it had. In layman terms, it's like testing if your water is contaminated with bacteria by adding bacteria to it!

Scientific Basis for the Link to Cancer

There are reports that claim GW-501516 increases carcinogenesis through a number of ways: increasing cell growth due to the inhibition of apoptosis (cell death), promoting cell proliferation (cell growth) by increasing cyclooxygenase-2 (COX2) and/or vascular endothelial growth factor (VEGF). These reports claim GW can lead to inhibition of apoptosis in human colon cancer cell lines; stimulate proliferation of human liver, breast, and prostate cancer cell lines; increases COX2 expression in human liver cancer cell lines and increased expression of VEGF in breast and colon cancer cell lines. Mainly, the reports link to the above mentioned flawed study done on rodents.
tumor-progression-tumor suppression

Fig 2. Tumor Progression vs. Tumor Suppression

Arguments Against Cancer

Scientific Basis Against Link to Cancer

Although some reports do provide an argument for cancer, there are many other findings that are inconsistent with the viewpoint. For example, GW is an-501516 anti-inflammatory in many cell types; colon epithelium, macrophages, cardiomyocytes, immune cells, keratinocytes, myoblasts, endothelial cells, and hepatocytes. Evidence also suggest that GW-501516 (cardarine) promotes differentiation in intestinal epithelium, breast and colon cancer cell lines, trophoblasts and primary keratinocytes. This means it allows cells to become more specialized cells maintaining a natural limitation of certain cell types, without such a limitation, basic cells would run rampant invading areas they typically do not belong. GW has also been demonstrated inhibition of cell growth in a number of cells.

Summary of arguments against cancer:

GW is an anti-inflammatory in many cells
GW limits cancers
GW inhibits high cell growth
GW reduces cancer risks

Studies

A study was done in an attempt to discover why so many inconsistencies existed about GW. This study took three human colon cancer cell lines and two human liver cancer cell lines and tested using different models. Model 1, in the presence of or lack of serum, and, model 2, in the presence of or lack of GW, and studied them over culture period. The results were quantified using the Coulter Method, which is the gold standard of counting, to determine cell proliferation. Under the testing methods for this experiment, all five samples showed no changes in cell proliferation and failed to offer any evidence that PPARs such as GW increased cancer growth.
The Coulter Principle


There are also some reports on all the beneficial properties of GW-50516/Cardarine.

 

[broheim]

PEG300, 20mg not 30mg brother.

You might try to micronize it or pulverize it into a finer powder in a small bowl or beaker. Then add just little bit of solution to make it pasty and grind up any remaining chunks with a clean round tool. Then add the mix into your bottle. You will need to slowly clean the dish to recover the residual GW and pour into bottle. After that just mix your solution as desired, to top off and there it is. This will predissolve it and make it go into suspension much better and; will even out the doses more accurately. You still may need to shake it up prior to each dose. Cardarine is just not very soluble. I had to experiment a bit to find the right method, and this one has worked for me. Have some fun in the lab bro. Hope it helps

Note: Reply is to Smack's question

 

[broheim]

What kind of solution? I tried 30mg/ml in grain alcohol and it's pretty chunky

You might try to micronize it or pulverize it into a finer powder in a small bowl or beaker. Then add just little bit of solution to make it pasty and grind up any remaining chunks with a clean round tool. Then add the mix into your bottle. You will need to slowly clean the dish to recover the residual GW and pour into bottle. After that just mix your solution as desired, to top off and there it is. This will predissolve it and make it go into suspension much better and; will even out the doses more accurately. You still may need to shake it up prior to each dose. Cardarine is just not very soluble. I had to experiment a bit to find the right method, and this one has worked for me. Have some fun in the lab bro. Hope it helps

 

[allornothing]

you read the whole study right....

after liver injury

i did.... that's why I asked because I was confused after. I knew someone here would be able to clear things up. I really like the stuff and didn't want to stop.

 

[allornothing]

There are also other studies showing it heals the liver.

Thanks Mike!!! I knew you would know. The study just left me confused. I needed someone smarter than me to clear it up.

 

[warlock]

In the research study it states that the the mice were dosed with something like 400 times the effective dose for a period of months on end without a break. Also not all the mice got ill, some were actually still healthy.

The endurance, fat burning and nutrient partitioning effects are undeniable for me. I have cycled a few times always with very noticeable result within days. Also knock lethargy while on cycle right in the dirt. Not to mention faster recovery times and less DOMS. Professional Olympic cyclists, and endurance athletes have been using it for years to enhance performance with no negative results reported to date.

Is there anyone that has reported any side effect or tumors as a result of cardarine usage?

What dose do you typically use and for how long? How soon do you notice results?

 

[Smack]

You might try to micronize it or pulverize it into a finer powder in a small bowl or beaker. Then add just little bit of solution to make it pasty and grind up any remaining chunks with a clean round tool. Then add the mix into your bottle. You will need to slowly clean the dish to recover the residual GW and pour into bottle. After that just mix your solution as desired, to top off and there it is. This will predissolve it and make it go into suspension much better and; will even out the doses more accurately. You still may need to shake it up prior to each dose. Cardarine is just not very soluble. I had to experiment a bit to find the right method, and this one has worked for me. Have some fun in the lab bro. Hope it helps

Thanks man. I actually had much better luck with a different supplier while using grain alcohol.

I thought it was pretty standard protocol but lack of results has me thinking maybe the grain alcohol degrades the GW? Two different highly reviewed suppliers I got powder from and haven't noticed much at all. Is grain alcohol ok to use as a solution or am I missing something?

 

[aphextwin]

Mike's GW is simply phenomenal. I'm so impressed with my endurance and fat loss in such a short period.

 

[jcc80]

Well, I just ordered some of Mike's GW for my wife. All she heard was 'fat loss' and she was all over it like flies on shit. I have to admit I'm a bit intrigued too, but I need to pick and choose what I spend money on.

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[RamboStallone]

How about the OP of this thread being debunked! Scientists warning athletes? Seems like more anti-PED agendas. And it's been proven to be bullshit now. Yet again.

 

[Matsuo Munefusa]

You might try to micronize it or pulverize it into a finer powder in a small bowl or beaker. Then add just little bit of solution to make it pasty and grind up any remaining chunks with a clean round tool. Then add the mix into your bottle. You will need to slowly clean the dish to recover the residual GW and pour into bottle. After that just mix your solution as desired, to top off and there it is. This will predissolve it and make it go into suspension much better and; will even out the doses more accurately. You still may need to shake it up prior to each dose. Cardarine is just not very soluble. I had to experiment a bit to find the right method, and this one has worked for me. Have some fun in the lab bro. Hope it helps

Note: Reply is to Smack's question

if its soluble in some kind of solvent like USP dichloroform or USP benzyl alcohol you could always dissolve it in that and evaporate the solvent. The residue would be the cardarine in a fine powder that may suspend much easier in your PEG.

 

[Matsuo Munefusa]

Mike's GW is simply phenomenal. I'm so impressed with my endurance and fat loss in such a short period.

what's your dose? I heard some people were having a lot of trouble with side effects like insomnia and headaches at 20mg/day.

 

[Matsuo Munefusa]

Thanks man. I actually had much better luck with a different supplier while using grain alcohol.

I thought it was pretty standard protocol but lack of results has me thinking maybe the grain alcohol degrades the GW? Two different highly reviewed suppliers I got powder from and haven't noticed much at all. Is grain alcohol ok to use as a solution or am I missing something?

hint, a lot of compounds degrade at certain PHs so taking a look at the range of PHs for your solvents you're using is CRITICAL.

 

[aphextwin]

what's your dose? I heard some people were having a lot of trouble with side effects like insomnia and headaches at 20mg/day.

I'm currently running 20 mgs a day. I haven't experienced any side effects. I will probably drop it down to 10mgs a dsy in the next month. Personally, I believe 10mgs is fine.