HIGH INSULIN dosage and elevated GGT

[OuchThatHurts]

This is interesting:

”GGT is a nonspecific marker that is known to rise in patients with type 2 diabetes. In epidemiological studies, it has a positive association with alcohol intake, cigarette smoking, coronary heart disease, BMI, systolic blood pressure, serum triglyceride, heart rate, uric acid, and hematocrit [most of which are common among BBers]. It has an inverse association with physical activity level.[6] Because GGT increases in diabetes, and increases as BMI increases, it has been proposed as another marker of insulin resistance.
To determine whether elevated GGT could predict the development of type 2 diabetes, a prospective cohort study of 7,458 nondiabetic men aged 40-59 years was conducted for 12 years.[7]Mean serum GGT at the start of the study was significantly higher in the 194 men who developed type 2 diabetes than in the rest of the cohort who did not develop diabetes (20.9 vs. 15.3 units/l, P < 0.0001). The association was independent of serum glucose and BMI.”

6. Wannamethee G, Ebrahim S, Shaper AG: Gamma-glutamyltransferase: determinants and associations with mortality from ischaemic heart disease and all causes.
Am J Epidemiol 42:699-708, 1995

7. Perry IJ, Wannamethee SG, Shaper AG: Prospective study of serum gamma-glutamyltransferase and risk of NIDDM.
Diabetes Care 21: 732-737,1998

 

[luki7788]

This is interesting:

”GGT is a nonspecific marker that is known to rise in patients with type 2 diabetes. In epidemiological studies, it has a positive association with alcohol intake, cigarette smoking, coronary heart disease, BMI, systolic blood pressure, serum triglyceride, heart rate, uric acid, and hematocrit [most of which are common among BBers]. It has an inverse association with physical activity level.[6] Because GGT increases in diabetes, and increases as BMI increases, it has been proposed as another marker of insulin resistance.
To determine whether elevated GGT could predict the development of type 2 diabetes, a prospective cohort study of 7,458 nondiabetic men aged 40-59 years was conducted for 12 years.[7]Mean serum GGT at the start of the study was significantly higher in the 194 men who developed type 2 diabetes than in the rest of the cohort who did not develop diabetes (20.9 vs. 15.3 units/l, P < 0.0001). The association was independent of serum glucose and BMI.”

6. Wannamethee G, Ebrahim S, Shaper AG: Gamma-glutamyltransferase: determinants and associations with mortality from ischaemic heart disease and all causes.
Am J Epidemiol 42:699-708, 1995

7. Perry IJ, Wannamethee SG, Shaper AG: Prospective study of serum gamma-glutamyltransferase and risk of NIDDM.
Diabetes Care 21: 732-737,1998

very interesting - it kind of aligns with my line of thinking

 

[Fibrado]

My question is for people who use or have experimented with higher doses of insulin for a longer period of time.

So on topic - I noticed in myself and also in a few other people who use high doses of insulin an increase in the liver GGT parameter. No one I talked to could explain it because all the rest, i.e. alt, ast, bilirubin, alkaline phase, are in the norm. Even ultrasound of the liver shows absolutely no changes or enlargement. Now I managed to find studies that say that high ggtp may be related to the development of type 2 diabetes - this could be true because all the people I know with the same condition use high doses of gh and insulin.

Personally I think the high use of synthetic insulin can falsify the GGT result in some way? it would even make sense since even an ultrasound examination shows absolutely no negative changes in the liver

Has anyone else who uses high doses of insulin noticed a similar thing in themselves?

Brother this makes all sense because 2 years ago I was using over 15 ius hgh and over 100ius slin day and my GGT was 937 . Crazy high . I go to trt and it goes down to 359 in 3 months or less .

Now what I don’t understand is this fake value on blood test or Slin increase ggt really ?

 

[luki7788]

Brother this makes all sense because 2 years ago I was using over 15 ius hgh and over 100ius slin day and my GGT was 937 . Crazy high . I go to trt and it goes down to 359 in 3 months or less .

Now what I don’t understand is this fake value on blood test or Slin increase ggt really ?

no bro - now I know that this was not the cause - look at my topic and review the last few pages - there I described the problem