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- May 19, 2004
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It does depend on individual chemistry, just like pain tolerance. I know for a fact that alcoholics -it s been confirmed my medicine, idk if it officially but my dad is a doctor and say what he s seen and knows... ( which also a gaba related drug) can't react much to full anesthesia...the liver just destroys that chemical, but that doesnt go for local anesthetics....just like any gaba drug - liver controls that - wehn i ve taken lets say 4 mg of xanax and two hrs or so later go out and drink, it s much harder to get drunk, and with phenibut - forget about it...that day i took 2500mg I slept during day and in the evening went out .i had a drink after drink - I probably had 750ml of rumin a matter of a 2-3 hrs, and was just barely buzzed...in fact thts how addiction happens with benzos, brain recognizes high gaba levels and livers start destroying more of the chemical that comes orally and u start feeling less and less effect, supposedly GHB doesnt do that but it s a nasty drug, eventhou used in a certain RX med
I think in alcoholics drugs are metabolized LESS, heard lots of stories of end stage alcoholics getting wasted on one light beer because the liver is wrecked.
Just checked and some anesthetics and morphine metabolism is reduced so dose should be reduced in alcoholic liver disease. Though the article I quickly scanned said some drug dosages should be reduced.
But my understanding is that plasma levels of various drugs are increased with liver and kidney diseases because they aren't metabolizing them effectively.
If someone has abused say benzos I think there is cross tolerance with other gabaergics.
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