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- Aug 30, 2014
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Yeah I dug up that (or a similar) study after I posted and decided not to pursue it. I may go the ipam route, perhaps 300mcg before bed with 100mcg mod grf. Perhaps some hex for preworkout.I am the same with MK-677. I just ordered from peptidetech and was gutted they have no hexarelin as I wanted to add that in. Hexarelin causes a very sharp gh spike post injection. It can also influence cortisol and prolactin release during it's active life. I think it's fantastic dosed throughout the day. But one major study did show it to negatively effect sleep quality when dosed pre bed.
GHRH's generally increase sleep quality so I would recommend CJC-DAC to you. Tesamorelin is another good one but I feel cjc-dac is superior. CJC-DAC should give you sleep and skin benefits. If you wanted to try a GHRP pre bed go with Ipamorelin as that will have no effect on cortisol or prolactin. The only issue with Ipam is you have to dose it fairly high for it to shine so it's not the most cost effective peptide. Although if you try it 300mcg may be ok but I would recommend 500mcg+
Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers.
Frieboes RM1, Antonijevic IA, Held K, Murck H, Pollmächer T, Uhr M, Steiger A.
Ghrelin, the endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor and some GHSs exert different effects on sleep electroencephalogram (EEG) and sleep-related hormone secretion in humans. Similar to GH-releasing hormone (GHRH) ghrelin promotes slow-wave sleep in humans, whereas GH-releasing peptide-6 (GHRP-6) enhances stage 2 nonrapid-eye movement sleep (NREMS). As GHRP-6, hexarelin is a synthetic GHS. Hexarelin is superior to GHRH and GHRP-6 in stimulating GH release. The influence of hexarelin on sleep-endocrine activity and the immune system is unknown. We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h. Following hexarelin, stage 4 sleep during the first half of the night, and EEG delta power during the total night decreased significantly. Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found. Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged. We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system.
PMID: 15177700 DOI: 10.1016/S0306-4530(03)00152-5
When I read the study about hex decreasing slow wave sleep, I briefly thought about trying DSIP at the same time. But I highly doubt I'm going to find clinical studies proving or disproving the efficacy of that.... And I don't have a whole lot of money laying around for experimentation.
I decided to finish the rest of my MK-677 at a dose of roughly 7mg per night and that's not so bad.
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